Dissecting the human immunologic memory for pathogens

Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental...

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Published inImmunological reviews Vol. 240; no. 1; pp. 40 - 51
Main Authors Zielinski, Christina E., Corti, Davide, Mele, Federico, Pinto, Dora, Lanzavecchia, Antonio, Sallusto, Federica
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2011
Subjects
analytic vaccinology
Animal models
B cells
B-Lymphocytes - immunology
Cell culture
Drug Design
Host-Pathogen Interactions
Humans
Immunologic Memory
Immunological memory
Lymphocytes B
Lymphocytes T
Memory cells
Pathogens
Plasma cells
Reviews
T cells
T-Lymphocytes - immunology
Vaccines
Vaccines - immunology
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Summary:Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as ‘analytic vaccinology’.
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ArticleID:IMR1000
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Feature-1
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.2010.01000.x