Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

• Published in: Developmental cell Vol. 14; no. 1; pp. 25 - 36
• Main Authors: Gavard, Julie, Patel, Vyomesh, Gutkind, J. Silvio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2008
• Subjects: Adaptor Proteins, Signal Transducing - drug effects; Adaptor Proteins, Signal Transducing - physiology; Angiopoietin-1 - pharmacology; Antigens, CD - physiology; Cadherins - physiology; Carrier Proteins - physiology; Cell Membrane Permeability - drug effects; Cell Movement - drug effects; Cells, Cultured; Endocytosis - drug effects; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Fluorescence Resonance Energy Transfer; Humans; HUMDISEASE; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - physiology; Signal Transduction - drug effects; Signal Transduction - physiology; SIGNALING; Vascular Endothelial Growth Factor A - pharmacology; HUMDISEASE; SIGNALING

Vascular endothelial growth factor (VEGF) and Angiopoietin 1 (Ang1) are both potent proangiogenic factors, but, whereas VEGF causes vascular permeability, Ang1 stabilizes blood vessels and protects them from VEGF-induced plasma leakage. The antivascular permeability mechanisms deployed by Ang1 are s...