CD44 splice variant (CD44v3) promotes progression of urothelial carcinoma of bladder through Akt/ERK/STAT3 pathways: novel therapeutic approach

• Published in: Journal of cancer research and clinical oncology Vol. 145; no. 11; pp. 2649 - 2661
• Main Authors: Anand, Vivek, Khandelwal, Madhuram, Appunni, Sandeep, Gupta, Nidhi, Seth, Amlesh, Singh, Prabhjot, Mathur, Sandeep, Sharma, Alpana
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2019; Springer Nature B.V
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - pathology; AKT protein; Alternative Splicing; Apoptosis; Bladder cancer; Cancer Research; CD44 antigen; Cell cycle; Cell Proliferation; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Extracellular matrix; Extracellular signal-regulated kinase; Gene Expression Regulation, Neoplastic; Hematology; Humans; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; Hyaluronic acid; Internal Medicine; Medicine; Medicine & Public Health; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; Oncology; Original Article – Cancer Research; Original – Cancer Research; Prognosis; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Tumor Cells, Cultured; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Urothelial carcinoma; Hyaluronic acid synthase; 4-Methylumbelliferone; Hyaluronic acid; CD44 variant 3; Bladder cancer; CD44
• ISSN: 0171-5216; 1432-1335; 1432-1335
• DOI: 10.1007/s00432-019-03024-9

Purpose The incidence of Urothelial carcinoma of bladder (UBC) is gradually increasing by changing lifestyle and environment. The development of a tumor has been noted to be accompanied by modifications in the extracellular matrix (ECM) consisting of CD44, hyaluronic acid (HA) and its family members...