Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells

• Published in: British journal of cancer Vol. 96; no. 6; pp. 993 - 1000
• Main Authors: Liau, S-S, Jazag, A, Ito, K, Whang, E E
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 26.03.2007
• Subjects: Adenoviruses; Anoikis - physiology; Apoptosis; Apoptosis - genetics; Apoptosis - physiology; Cancer research; Carcinoma, Pancreatic Ductal - enzymology; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Caspase 3 - genetics; Caspase 3 - metabolism; Cell Growth Processes - physiology; Cell Line, Tumor; Cloning; Enzyme Activation; HMGA Proteins - biosynthesis; HMGA Proteins - genetics; HMGA Proteins - metabolism; Humans; Hypotheses; Infections; Kinases; Medical prognosis; Medical research; Metastasis; Molecular Diagnostics; Oncogene Protein v-akt - antagonists & inhibitors; Oncogene Protein v-akt - metabolism; Pancreatic Neoplasms - enzymology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Proteins; RNA Interference; Signal Transduction; Transcription factors; United States > US

HMGA1 proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. Roles of HMGA1 in mediating the malignant phenotype of this cancer are poorly understood. We tested the hypothesis that overexpression of HMGA1 promotes resistance to anoikis (apoptosis induc...