Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

• Published in: Circulation (New York, N.Y.) Vol. 120; no. 2; pp. 150 - 159
• Main Authors: Tchaikovski, Vadim, Olieslagers, Servé, Böhmer, Frank -D., Waltenberger, Johannes
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 14.07.2009
• Subjects: Aged; Arteries - physiopathology; Associated diseases and complications; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Diabetes Mellitus - physiopathology; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Glycation End Products, Advanced - metabolism; Humans; Male; Medical sciences; Middle Aged; Mitogen-Activated Protein Kinase 3 - metabolism; Monocytes - physiology; Neovascularization, Pathologic - physiopathology; Oxidative Stress - physiology; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation - physiology; Proto-Oncogene Proteins c-akt - metabolism; Receptor for Advanced Glycation End Products; Receptors, Immunologic - metabolism; Signal Transduction - physiology; Vascular Endothelial Growth Factor A - physiology; Vascular Endothelial Growth Factor Receptor-1 - metabolism; Endocrinopathy; Human; Signal transduction; monocytes; Growth factor receptor; Monocyte; Vascular resistance; Diabetes mellitus; Cardiovascular disease; vascular endothelial growth factor receptor-1; Growth factor

Background— Monocytes are cellular components of wound repair, arteriogenesis, and atherogenesis. Vascular endothelial growth factor (VEGF)-A and placental growth factor recruit monocytes to sites of arteriogenesis via stimulation of VEGF receptor-1 (VEGFR-1). The chemotactic response of monocytes t...