Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease

• Published in: Frontiers in neurology Vol. 13; p. 826102
• Main Authors: Moudio, Serge, Rodin, Fredrik, Albargothy, Nazira Jamal, Karlsson, Urban, Reyes, Juan F., Hallbeck, Martin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.02.2022
• Subjects: autophagy; Neurology; organotypic slice cultures; Parkinson's disease; PFF; α-synuclein; PFF; Parkinson's disease; autophagy; model of CNS disease; organotypic slice cultures; α-synuclein; 3R; Lewy bodies; Parkinsons disease; alpha-synuclein

The accumulation of proteinaceous deposits comprised largely of the α-synuclein protein is one of the main hallmarks of Parkinson's disease (PD) and related synucleinopathies. Their progressive development coincides with site-specific phosphorylation, oxidative stress and eventually, compromise...