Rapid Assessment of Phenotypic Resistance to Protease Inhibitors in Human Immunodeficiency Virus Type 1 Group O
Erratum ( vol. 41 , p. 527 ) Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from th...
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| Published in | Journal of Clinical Microbiology Vol. 40; no. 11; pp. 4313 - 4316 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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American Society for Microbiology
01.11.2002
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| Online Access | Get full text |
| ISSN | 0095-1137 1098-660X |
| DOI | 10.1128/JCM.40.11.4313-4316.2002 |
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| Abstract | Erratum
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| AbstractList | A bacteriophage lambda-based method was used to investigate the development of resistance to protease inhibitors (PI) in one subject infected with human immunodeficiency virus (HIV) type 1 group O who underwent multiple treatment regimens over a period of 4 years. A reduction in the susceptibility to indinavir of 6-fold and a reduction in the susceptibility to saquinavir of 24-fold were recognized after long exposure to these drugs with respect to baseline. The emergence of PI resistance corresponded to the selection of amino acid changes L10V, G48M, F53L, I54V, and L90M at the protease. The results were concordant with those obtained by a drug susceptibility assay with primary HIV isolates. A bacteriophage lambda-based method was used to investigate the development of resistance to protease inhibitors (PI) in one subject infected with human immunodeficiency virus (HIV) type 1 group O who underwent multiple treatment regimens over a period of 4 years. A reduction in the susceptibility to indinavir of 6-fold and a reduction in the susceptibility to saquinavir of 24-fold were recognized after long exposure to these drugs with respect to baseline. The emergence of PI resistance corresponded to the selection of amino acid changes L10V, G48M, F53L, I54V, and L90M at the protease. The results were concordant with those obtained by a drug susceptibility assay with primary HIV isolates.A bacteriophage lambda-based method was used to investigate the development of resistance to protease inhibitors (PI) in one subject infected with human immunodeficiency virus (HIV) type 1 group O who underwent multiple treatment regimens over a period of 4 years. A reduction in the susceptibility to indinavir of 6-fold and a reduction in the susceptibility to saquinavir of 24-fold were recognized after long exposure to these drugs with respect to baseline. The emergence of PI resistance corresponded to the selection of amino acid changes L10V, G48M, F53L, I54V, and L90M at the protease. The results were concordant with those obtained by a drug susceptibility assay with primary HIV isolates. Erratum ( vol. 41 , p. 527 ) Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology. For an alternate route to JCM .asm.org, visit: JCM |
| Author | Eva Poveda Berta Rodés Vincent Soriano |
| AuthorAffiliation | Department of Infectious Diseases, Hospital Carlos III, Instituto de Salud Carlos III, Madrid, Spain |
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| Cites_doi | 10.1089/088922201750461302 10.1128/jvi.71.11.8893-8898.1997 10.1016/S0891-5520(05)70407-4 10.1089/08892220152644269 10.1006/viro.1994.1640 10.1073/pnas.95.6.2828 10.1002/jmv.1039 10.1128/AAC.44.5.1132-1139.2000 10.1002/(SICI)1096-9071(199703)51:3<202::AID-JMV10>3.0.CO;2-M 10.1128/JVI.72.11.9002-9015.1998 10.1089/08892220050140937 10.1006/viro.1997.8748 |
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| Keywords | HIV-1 virus Siphoviridae Metalloendopeptidases Saquinavir Pitrilysin Development Antiviral Phage lambda Indinavir Immunopathology Enzyme Retroviridae Enzyme inhibitor AIDS Immune deficiency Lentivirus Infection Virus Resistance Peptidases Sensitivity Treatment Viral disease Hydrolases Isolate Human immunodeficiency virus Protease inhibitor Phage |
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| References | (e_1_3_1_15_2) 1999; 7 (e_1_3_1_7_2) 1996; 107 e_1_3_1_8_2 e_1_3_1_13_2 e_1_3_1_12_2 e_1_3_1_11_2 e_1_3_1_9_2 e_1_3_1_10_2 e_1_3_1_4_2 e_1_3_1_17_2 e_1_3_1_3_2 e_1_3_1_6_2 (e_1_3_1_16_2) 2000; 2 e_1_3_1_5_2 e_1_3_1_14_2 e_1_3_1_2_2 e_1_3_1_18_2 J Clin Microbiol. 2003 Jan;41(1):527. |
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| SubjectTerms | Adult Amino Acid Sequence Bacteriology Bacteriophage lambda - drug effects Bacteriophage lambda - genetics Biological and medical sciences Drug Resistance, Viral Female Fundamental and applied biological sciences. Psychology HIV Protease - drug effects HIV Protease - genetics HIV Protease Inhibitors - pharmacology HIV-1 - classification HIV-1 - drug effects Humans Indinavir - pharmacology Male Microbial Sensitivity Tests - methods Microbiology Molecular Sequence Data Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phenotype Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Saquinavir - pharmacology Time Factors Virology |
| Title | Rapid Assessment of Phenotypic Resistance to Protease Inhibitors in Human Immunodeficiency Virus Type 1 Group O |
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