Prefrontal Dopaminergic and Enkephalinergic Synaptic Accommodation in HIV-associated Neurocognitive Disorders and Encephalitis

• Published in: Journal of neuroimmune pharmacology Vol. 7; no. 3; pp. 686 - 700
• Main Authors: Gelman, Benjamin B., Lisinicchia, Joshua G., Chen, Tianshen, Johnson, Kenneth M., Jennings, Kristofer, Freeman, Daniel H., Soukup, Vicki M.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2012; Springer Nature B.V
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; AIDS Dementia Complex - drug therapy; AIDS Dementia Complex - metabolism; AIDS Dementia Complex - pathology; Antiretroviral Therapy, Highly Active - methods; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Cognition; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cognition Disorders - pathology; Cortex; Cortex (prefrontal); Dopamine; Dopamine receptors; Encephalitis; Encephalitis - drug therapy; Encephalitis - metabolism; Encephalitis - pathology; Enkephalins - biosynthesis; Female; Hand; HIV Infections - drug therapy; HIV Infections - metabolism; HIV Infections - pathology; HIV-1; Human immunodeficiency virus 1; Humans; Immunology; Interferon regulatory factor 1; Male; Middle Aged; mRNA; Neuropathology; Neurosciences; Neurotransmitters; Opioids; Original; Original Article; Pharmacology/Toxicology; Plasticity (synaptic); Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Preproenkephalin; Protein Precursors - biosynthesis; Receptors, Dopamine D2 - biosynthesis; Sampling; Synapses; Synapses - drug effects; Synapses - metabolism; Synapses - pathology; Synaptic transmission; Virology; Opiate; HIVE; Dopamine receptor; Enkephalin; HIV-associated neurocognitive disorders; Synaptic plasticity; Opioid; HAND; Interferon regulatory factor; HIV encephalitis

Changes in synapse structure occur in frontal neocortex with HIV encephalitis (HIVE) and may contribute to HIV-associated neurocognitive disorders (HAND). A postmortem survey was conducted to determine if mRNAs involved in synaptic transmission are perturbed in dorsolateral prefrontal cortex (DLPFC)...