Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population

• Published in: Clinical & developmental immunology Vol. 2012; no. 2012; pp. 1 - 7
• Main Authors: You, Zeshan, Wu, Zaigui, Zhang, Cai, Li, Zhuyu, Su, Xiumei, Zhang, Xiuming, Li, Yinguang
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2012; Hindawi Publishing Corporation; Wiley
• Subjects: Abortion, Spontaneous - genetics; Abortion, Spontaneous - physiopathology; Adult; Autoimmunity - genetics; China; Clinical Study; DNA Mutational Analysis; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - immunology; Forkhead Transcription Factors - metabolism; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Polymorphism, Genetic; Recurrence; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - pathology; China

Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the develo...