Liver X receptor regulates Th17 and RORγt+ Treg cells by distinct mechanisms

• Published in: Mucosal immunology Vol. 14; no. 2; pp. 411 - 419
• Main Authors: Parigi, Sara M., Das, Srustidhar, Frede, Annika, Cardoso, Rebeca F., Tripathi, Kumar Parijat, Doñas, Cristian, Hu, Yue O.O., Antonson, Per, Engstrand, Lars, Gustafsson, Jan-Åke, Villablanca, Eduardo J.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.03.2021; Nature Publishing Group US; Elsevier Limited
• Subjects: Allergology; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; CD11c antigen; CD4 antigen; Cell Differentiation; Cholesterol; Cholesterol - metabolism; Epithelial cells; Gastroenterology; Gastrointestinal Microbiome - immunology; Helper cells; Horizontal cells; Horizontal transfer; Immunology; Immunomodulation; Intestine; Intestines - immunology; Liver X receptors; Liver X Receptors - genetics; Liver X Receptors - metabolism; Lymph nodes; Lymph Nodes - immunology; Lymphocyte Activation; Lymphocytes T; Metabolites; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Microenvironments; Myeloid cells; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Nuclear receptors; Rodents; T-Lymphocytes, Regulatory - immunology; Th17 Cells - immunology

The gastrointestinal microenvironment, dominated by dietary compounds and the commensal bacteria, is a major driver of intestinal CD4+ T helper (Th) cell differentiation. Dietary compounds can be sensed by nuclear receptors (NRs) that consequently exert pleiotropic effects including immune modulatio...