HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis

• Published in: Journal of assisted reproduction and genetics Vol. 30; no. 11; pp. 1505 - 1512
• Main Authors: Jana, Saikat Kumar, Banerjee, Priyanka, Mukherjee, Rashmi, Chakravarty, Baidyanath, Chaudhury, Koel
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.11.2013; Springer Nature B.V
• Subjects: Adult; Age; Blotting, Western; Case-Control Studies; Electron microscopes; Embryo Implantation; Endometriosis; Endometriosis - complications; Endometriosis - metabolism; Endometriosis - pathology; Endometrium; Endometrium - metabolism; Endometrium - pathology; Female; Flow Cytometry; Genes; Gonadal Physiology and Disease; Gynecology; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Human Genetics; Humans; Immunoenzyme Techniques; Infertility; Infertility, Female - etiology; Infertility, Female - metabolism; Infertility, Female - pathology; Laparoscopy; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Medicine; Medicine & Public Health; Menstruation; Microscopy, Atomic Force; Morphology; Ovulation; Real-Time Polymerase Chain Reaction; Reproductive health; Reproductive Medicine; West Bengal India; India; Atomic force microscopy; Endometriosis; HOXA gene; Endometrial receptivity; Endometrium

Purpose To investigate the Homeobox genes HOXA-10 and HOXA-11 mediated endometrial molecular defects during implantation window in endometriosis-associated infertility cases. Methods Endometrial biopsies were obtained during implantation window from 31 infertile women with endometriosis (age < 35...