Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform

• Published in: Blood Vol. 117; no. 19; pp. 5166 - 5177
• Main Authors: Slatter, Tania L., Hung, Noelyn, Campbell, Hamish, Rubio, Carina, Mehta, Reena, Renshaw, Prudence, Williams, Gail, Wilson, Michelle, Engelmann, Afra, Jeffs, Aaron, Royds, Janice A., Baird, Margaret A., Braithwaite, Antony W.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 12.05.2011; Americain Society of Hematology
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Blotting, Western; Cell Proliferation; Fluorescent Antibody Technique; Gene Expression; Gene Expression Profiling; Hematologic and hematopoietic diseases; Humans; Inflammation - genetics; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Neoplasms, Experimental - genetics; Oligonucleotide Array Sequence Analysis; Protein Isoforms - genetics; Reverse Transcriptase Polymerase Chain Reaction; Transduction, Genetic; Tumor Suppressor Protein p53 - genetics; Cell proliferation; Vertebrata; Molecular form; Mammalia; Hematology; Mouse; Animal; Rodentia; Inflammation; Malignant tumor; Cancer

The p53 protein is a pivotal tumor suppressor that is frequently mutated in many human cancers, although precisely how p53 prevents tumors is still unclear. To add to its complexity, several isoforms of human p53 have now been reported. The Δ133p53 isoform is generated from an alternative transcript...