The PI3K/Akt, p38MAPK, and JAK2/STAT3 signaling pathways mediate the protection of SO2 against acute lung injury induced by limb ischemia/reperfusion in rats

• Published in: The journal of physiological sciences Vol. 66; no. 3; pp. 229 - 239
• Main Authors: Zhao, Yan-Rui, Wang, Dong, Liu, Yang, Shan, Lei, Zhou, Jun-Lin
• Format: Journal Article
• Language: English
• Published: Japan Elsevier Inc 01.05.2016; Springer Japan
• Subjects: Acute lung injury; Acute Lung Injury - etiology; Acute Lung Injury - physiopathology; Animals; Extremities - blood supply; Inhibitor; Interleukins - physiology; Ischemia - complications; Ischemia - physiopathology; Ischemia/reperfusion; JAK2/STAT3; Janus Kinase 2 - physiology; Male; MAP Kinase Signaling System - physiology; Na2SO3/NaHSO3; Oncogene Protein v-akt - physiology; Original Paper; p38 MAPK; Phosphatidylinositol 3-Kinases - physiology; PI3K/Akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury - complications; Reperfusion Injury - physiopathology; Signal Transduction - physiology; STAT3 Transcription Factor - physiology; Sulfur dioxide; Sulfur Dioxide - metabolism; Acute lung injury; Na2SO3/NaHSO3; JAK2/STAT3; Inhibitor; Ischemia/reperfusion; p38 MAPK; Sulfur dioxide; PI3K/Akt

Sulfur dioxide (SO2) is naturally synthesized by glutamate–oxaloacetate transaminase (GOT) from l-cysteine in mammalian cells. We found that SO2 may have a protective effect on acute lung injury (ALI) induced by limb ischemia/reperfusion (I/R) in rats. The PI3K/Akt, p38MAPK, and JAK2/STAT3 pathways...