Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are evolutionarily conserved with humans

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 31; pp. 12762 - 12767
• Main Authors: Awan, Ali R., Manfredo, Amanda, Pleiss, Jeffrey A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 30.07.2013; National Acad Sciences
• Subjects: alternative splicing; Alternative Splicing - genetics; Biological Sciences; Conservation biology; Eukaryotes; eukaryotic cells; Evolution; Evolution, Molecular; exons; Exons - genetics; Gene expression; Humans; Phylogenetics; phylogeny; plants (botany); Proteomics; regulator genes; Schizosaccharomyces - genetics; Schizosaccharomyces pombe; Sequence Analysis, DNA; Vertebrates; Yeast; Yeasts; post-transcriptional gene regulation; phylogeny; pre-mRNA splicing

Alternative splicing is a potent regulator of gene expression that vastly increases proteomic diversity in multicellular eukaryotes and is associated with organismal complexity. Although alternative splicing is widespread in vertebrates, little is known about the evolutionary origins of this process...