Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression

• Published in: Molecular psychiatry Vol. 15; no. 10; pp. 987 - 995
• Main Authors: Garbett, K A, Horváth, S, Ebert, P J, Schmidt, M J, Lwin, K, Mitchell, A, Levitt, P, Mirnics, K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2010; Nature Publishing Group
• Subjects: 631/1647/767/1424; 631/208/176/2016; 631/378/1689/1799; Alternative Splicing; Animals; Artificial chromosomes; Behavioral Sciences; Biological Psychology; Brain Diseases - genetics; Brain Diseases - physiopathology; Brain research; Chromosomes, Artificial, Bacterial; Disease; Disease Models, Animal; Enzymes; Gene expression; Gene Expression Regulation - physiology; Gene Silencing; Genetic aspects; Glutamate Decarboxylase - genetics; Health aspects; HEK293 Cells; Humans; Medicine; Medicine & Public Health; Mice; Mice, Transgenic; MicroRNA; MicroRNAs; MicroRNAs - genetics; Neuropeptide Y; Neuropeptide Y - genetics; Neuropeptides; Neurosciences; Original; original-article; Pharmacotherapy; Physiological aspects; Psychiatry; Risk factors; Schizophrenia; Schizophrenia - genetics; Schizophrenia - physiopathology; United States; United States > US; Nashville Tennessee; miRNA; transgenic; schizophrenia; BAC; NPY; GAD1

In schizophrenia, glutamic acid decarboxylase 1 (GAD1) disturbances are robust, consistently observed, cell-type specific and represent a core feature of the disease. In addition, neuropeptide Y (NPY), which is a phenotypic marker of a sub-population of GAD1-containing interneurons, has shown reduce...