The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis

• Published in: Joint, bone, spine : revue du rhumatisme Vol. 81; no. 1; pp. 51 - 56
• Main Authors: Kerna, Irina, Kisand, Kalle, Suutre, Siim, Murde, Maret, Tamm, Ann, Kumm, Jaanika, Tamm, Agu
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 01.01.2014
• Subjects: ADAM Proteins - biosynthesis; ADAM12; ADAM12 Protein; Adult; Female; Fibrosis; Gene expression; Humans; Internal Medicine; Knee osteoarthritis; Male; Membrane Proteins - biosynthesis; Middle Aged; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - metabolism; Osteoarthritis, Knee - pathology; Radiography; Rheumatology; RNA, Messenger; Synovial Membrane - metabolism; Synovial Membrane - pathology; Synovitis; Synovitis - diagnostic imaging; Synovitis - metabolism; Synovitis - pathology; Up-Regulation; Synovitis; Knee osteoarthritis; Gene expression; ADAM12

To investigate the possible association between ADAM12 (disintegrin and metalloproteinase domain12) expression in the synovium and the histological synovitis of patients with radiographic knee osteoarthritis (rKOA). The synovial biopsy samples were harvested from 44 subjects with chronic knee compla...