Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors

• Published in: Blood Vol. 118; no. 19; pp. 5163 - 5173
• Main Authors: Heinonen, Krista M., Ruiz Vanegas, Juan, Brochu, Sylvie, Shan, Jingdong, Vainio, Seppo J., Perreault, Claude
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 10.11.2011; Americain Society of Hematology
• Subjects: Animals; Biological and medical sciences; Embryonic Stem Cells - cytology; Epithelial Cells - cytology; Female; Hematologic and hematopoietic diseases; Hematopoietic Stem Cells - cytology; Humans; Lymphopoiesis - genetics; Lymphopoiesis - physiology; Medical sciences; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Biological; Pregnancy; Thymus Gland - cytology; Thymus Gland - embryology; Thymus Gland - physiology; Wnt4 Protein - deficiency; Wnt4 Protein - genetics; Wnt4 Protein - physiology; Epithelial cell; Early; Thymus gland; Hematology; Expansion; Stem cell

Thymus atrophy is the most common immunopathology in humans, and its occurrence is hastened by several factors that coalesce in patients receiving chemotherapy and most of all in recipients of hematopoietic cell transplantation. We have shown previously that posthematopoietic cell transplantation th...