T-regulatory cells in severe atopic dermatitis: alterations related to cytokines and other lymphocyte subpopulations

• Published in: Archives of Dermatological Research Vol. 304; no. 10; pp. 795 - 801
• Main Authors: Samochocki, Zbigniew, Alifier, Marek, Bodera, Paweł, Jeziorkowska, Renata, Rosiak, Ewa, Jurkiewicz, Beata, Glińska, Olga, Gliński, Wiesław, Stankiewicz, Wanda
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.12.2012; Springer Nature B.V
• Subjects: Adolescent; Adult; Antigens, CD - immunology; Apoptosis; Atopic dermatitis; Blood Proteins - metabolism; CD134 antigen; CD152 antigen; CD28 antigen; CD4 antigen; CD62L protein; CD8 antigen; CD95 antigen; Cell activation; Cell culture; Cell Separation; Cell survival; Cytokines; Cytokines - immunology; Cytotoxicity; Dermatitis, Atopic - immunology; Dermatitis, Atopic - physiopathology; Dermatology; Disease Progression; Female; Flow Cytometry; Humans; Immunoregulation; Interleukin 10; Interleukin 6; Lymphocytes T; Male; Medicine; Medicine & Public Health; Monoclonal antibodies; Original Paper; Peripheral blood; Suppressor cells; Surface markers; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Regulatory - immunology; Transforming growth factor- beta; Young Adult; T-regulatory cells; SCORAD index; Immunological markers; Atopic dermatitis

The changes in lymphocyte subpopulations in atopic dermatitis (AD) concern also T-regulatory cells. We investigated the expression of various surface receptors on CD3 + CD4 + CD25 high FoxP3 + T-regulatory cells and the activation CD28 + receptor and the inhibitory CD152 + receptor on helper/inducer...