Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn
The aim of the present study was to investigate the effect of a μ-opioid receptor agonist DAMGO (Tyr- d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique an...
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Published in | Neuroscience Vol. 125; no. 4; pp. 995 - 1008 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
2004
Elsevier |
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Abstract | The aim of the present study was to investigate the effect of a μ-opioid receptor agonist DAMGO (Tyr-
d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for μ-opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. TRG neurons projecting onto the superficial layer of the cervical dorsal horn were retrogradely labeled with Fluorogold (FG). The cell diameter of FG-labeled TRG neurons was small (<30 μm). Under voltage-clamp (V
h=−60 mV), voltage-dependent K
+ currents were recorded in the TRG neurons and isolated by blocking Na
+ and Ca
2+ currents with appropriate ion replacement. Separation of the K
+ current components was achieved by the response to variation in the conditioning voltage. Two distinct K
+ current components, a transient (I
A) and sustained (I
K), were identified. DAMGO significantly increased I
A by 57% (20 μM) and in a dose-dependent manner (1–50 μM). Similarly, I
K was also enhanced by DAMGO administration (42%, 20 μM). The augmentation of both I
A and I
K was antagonized by a μ-opioid receptor antagonist, CTOP (
d-Phe-Cys-Thr-
d-Trp-Orn-Thr-Pen-Thr-NH
2). Hyperpolarization of the membrane potential was elicited by DAMGO (20 μM) and the response was associated with a decrease in the input resistance. DAMGO induced hyperpolarization was blocked by CTOP. DAMGO-sensitive I
A and I
K currents were antagonized by K
+ channel blockers, 4-aminopyridine (4-AP) and tetraethylammonium (TEA). In the presence of both 4-AP and TEA, no significant changes in membrane potential induced by DAMGO application were observed. In the presence of BaCl
2, DAMGO evoked hyperpolarization with decreased resistance was observed. The firing rate of action potentials and the first spike duration induced by depolarizing step pulses were decreased in the presence of DAMGO. RT-PCR analysis demonstrated the expression of mRNA for μ-opioid receptors in the trigeminal ganglia. The μ-opioid receptor immunoreactivity was expressed in the small diameter FG-labeled TRG neurons.
These results suggest that the activation of μ-opioid receptors inhibits the excitability of rat small diameter TRG neurons projecting on the superficial layer of the cervical dorsal horn and this inhibition is mediated by potentiation of voltage-dependent K
+ currents. We therefore concluded that modulation of nociceptive transmission in the trigeminal system, resulting in the functional activation of μ-opioid receptors, occurs at the level of small TRG cell bodies and/or their primary afferent terminals, which contribute to opioid analgesia in the trigeminal pain. |
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AbstractList | The aim of the present study was to investigate the effect of a micro-opioid receptor agonist DAMGO (Tyr-d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for micro-opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. TRG neurons projecting onto the superficial layer of the cervical dorsal horn were retrogradely labeled with Fluorogold (FG). The cell diameter of FG-labeled TRG neurons was small (<30 microm). Under voltage-clamp (V(h)=-60 mV), voltage-dependent K(+) currents were recorded in the TRG neurons and isolated by blocking Na(+) and Ca(2+) currents with appropriate ion replacement. Separation of the K(+) current components was achieved by the response to variation in the conditioning voltage. Two distinct K(+) current components, a transient (I(A)) and sustained (I(K)), were identified. DAMGO significantly increased I(A) by 57% (20 microM) and in a dose-dependent manner (1-50 microM). Similarly, I(K) was also enhanced by DAMGO administration (42%, 20 microM). The augmentation of both I(A) and I(K) was antagonized by a micro-opioid receptor antagonist, CTOP (d-Phe-Cys-Thr-d-Trp-Orn-Thr-Pen-Thr-NH(2)). Hyperpolarization of the membrane potential was elicited by DAMGO (20 microM) and the response was associated with a decrease in the input resistance. DAMGO induced hyperpolarization was blocked by CTOP. DAMGO-sensitive I(A) and I(K) currents were antagonized by K(+) channel blockers, 4-aminopyridine (4-AP) and tetraethylammonium (TEA). In the presence of both 4-AP and TEA, no significant changes in membrane potential induced by DAMGO application were observed. In the presence of BaCl(2), DAMGO evoked hyperpolarization with decreased resistance was observed. The firing rate of action potentials and the first spike duration induced by depolarizing step pulses were decreased in the presence of DAMGO. RT-PCR analysis demonstrated the expression of mRNA for micro-opioid receptors in the trigeminal ganglia. The micro-opioid receptor immunoreactivity was expressed in the small diameter FG-labeled TRG neurons. These results suggest that the activation of micro-opioid receptors inhibits the excitability of rat small diameter TRG neurons projecting on the superficial layer of the cervical dorsal horn and this inhibition is mediated by potentiation of voltage-dependent K(+) currents. We therefore concluded that modulation of nociceptive transmission in the trigeminal system, resulting in the functional activation of micro-opioid receptors, occurs at the level of small TRG cell bodies and/or their primary afferent terminals, which contribute to opioid analgesia in the trigeminal pain. The aim of the present study was to investigate the effect of a μ-opioid receptor agonist DAMGO (Tyr- d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for μ-opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. TRG neurons projecting onto the superficial layer of the cervical dorsal horn were retrogradely labeled with Fluorogold (FG). The cell diameter of FG-labeled TRG neurons was small (<30 μm). Under voltage-clamp (V h=−60 mV), voltage-dependent K + currents were recorded in the TRG neurons and isolated by blocking Na + and Ca 2+ currents with appropriate ion replacement. Separation of the K + current components was achieved by the response to variation in the conditioning voltage. Two distinct K + current components, a transient (I A) and sustained (I K), were identified. DAMGO significantly increased I A by 57% (20 μM) and in a dose-dependent manner (1–50 μM). Similarly, I K was also enhanced by DAMGO administration (42%, 20 μM). The augmentation of both I A and I K was antagonized by a μ-opioid receptor antagonist, CTOP ( d-Phe-Cys-Thr- d-Trp-Orn-Thr-Pen-Thr-NH 2). Hyperpolarization of the membrane potential was elicited by DAMGO (20 μM) and the response was associated with a decrease in the input resistance. DAMGO induced hyperpolarization was blocked by CTOP. DAMGO-sensitive I A and I K currents were antagonized by K + channel blockers, 4-aminopyridine (4-AP) and tetraethylammonium (TEA). In the presence of both 4-AP and TEA, no significant changes in membrane potential induced by DAMGO application were observed. In the presence of BaCl 2, DAMGO evoked hyperpolarization with decreased resistance was observed. The firing rate of action potentials and the first spike duration induced by depolarizing step pulses were decreased in the presence of DAMGO. RT-PCR analysis demonstrated the expression of mRNA for μ-opioid receptors in the trigeminal ganglia. The μ-opioid receptor immunoreactivity was expressed in the small diameter FG-labeled TRG neurons. These results suggest that the activation of μ-opioid receptors inhibits the excitability of rat small diameter TRG neurons projecting on the superficial layer of the cervical dorsal horn and this inhibition is mediated by potentiation of voltage-dependent K + currents. We therefore concluded that modulation of nociceptive transmission in the trigeminal system, resulting in the functional activation of μ-opioid receptors, occurs at the level of small TRG cell bodies and/or their primary afferent terminals, which contribute to opioid analgesia in the trigeminal pain. The aim of the present study was to investigate the effect of a micro-opioid receptor agonist DAMGO (Tyr-d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for micro-opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. TRG neurons projecting onto the superficial layer of the cervical dorsal horn were retrogradely labeled with Fluorogold (FG). The cell diameter of FG-labeled TRG neurons was small (<30 microm). Under voltage-clamp (V(h)=-60 mV), voltage-dependent K(+) currents were recorded in the TRG neurons and isolated by blocking Na(+) and Ca(2+) currents with appropriate ion replacement. Separation of the K(+) current components was achieved by the response to variation in the conditioning voltage. Two distinct K(+) current components, a transient (I(A)) and sustained (I(K)), were identified. DAMGO significantly increased I(A) by 57% (20 microM) and in a dose-dependent manner (1-50 microM). Similarly, I(K) was also enhanced by DAMGO administration (42%, 20 microM). The augmentation of both I(A) and I(K) was antagonized by a micro-opioid receptor antagonist, CTOP (d-Phe-Cys-Thr-d-Trp-Orn-Thr-Pen-Thr-NH(2)). Hyperpolarization of the membrane potential was elicited by DAMGO (20 microM) and the response was associated with a decrease in the input resistance. DAMGO induced hyperpolarization was blocked by CTOP. DAMGO-sensitive I(A) and I(K) currents were antagonized by K(+) channel blockers, 4-aminopyridine (4-AP) and tetraethylammonium (TEA). In the presence of both 4-AP and TEA, no significant changes in membrane potential induced by DAMGO application were observed. In the presence of BaCl(2), DAMGO evoked hyperpolarization with decreased resistance was observed. The firing rate of action potentials and the first spike duration induced by depolarizing step pulses were decreased in the presence of DAMGO. RT-PCR analysis demonstrated the expression of mRNA for micro-opioid receptors in the trigeminal ganglia. The micro-opioid receptor immunoreactivity was expressed in the small diameter FG-labeled TRG neurons. These results suggest that the activation of micro-opioid receptors inhibits the excitability of rat small diameter TRG neurons projecting on the superficial layer of the cervical dorsal horn and this inhibition is mediated by potentiation of voltage-dependent K(+) currents. We therefore concluded that modulation of nociceptive transmission in the trigeminal system, resulting in the functional activation of micro-opioid receptors, occurs at the level of small TRG cell bodies and/or their primary afferent terminals, which contribute to opioid analgesia in the trigeminal pain. The aim of the present study was to investigate the effect of a mu -opioid receptor agonist DAMGO (Tyr-D-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, by using the perforated-patch technique and to determine whether TRG neurons show the expression of mRNA or functional protein for mu -opioid receptors by using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. TRG neurons projecting onto the superficial layer of the cervical dorsal horn were retrogradely labeled with Fluorogold (FG). The cell diameter of FG-labeled TRG neurons was small (<30 mu m). Under voltage-clamp (V sub(h)=-60 mV), voltage-dependent K super(+) currents were recorded in the TRG neurons and isolated by blocking Na super(+) and Ca super(2+) currents with appropriate ion replacement. Separation of the K super(+) current components was achieved by the response to variation in the conditioning voltage. Two distinct K super(+) current components, a transient (I sub(A)) and sustained (I sub(K)), were identified. DAMGO significantly increased I sub(A) by 57% (20 mu M) and in a dose-dependent manner (1-50 mu M). Similarly, I sub(K) was also enhanced by DAMGO administration (42%, 20 mu M). The augmentation of both I sub(A) and I sub(K) was antagonized by a mu -opioid receptor antagonist, CTOP (D- Phe-Cys-Thr-D-Trp-Orn-Thr-Pen-Thr-NH sub(2)). Hyperpolarization of the membrane potential was elicited by DAMGO (20 mu M) and the response was associated with a decrease in the input resistance. DAMGO induced hyperpolarization was blocked by CTOP. DAMGO-sensitive I sub(A) and I sub(K) currents were antagonized by K super(+) channel blockers, 4-aminopyridine (4-AP) and tetraethylammonium (TEA). In the presence of both 4-AP and TEA, no significant changes in membrane potential induced by DAMGO application were observed. In the presence of BaCl sub(2), DAMGO evoked hyperpolarization with decreased resistance was observed. The firing rate of action potentials and the first spike duration induced by depolarizing step pulses were decreased in the presence of DAMGO. RT-PCR analysis demonstrated the expression of mRNA for mu -opioid receptors in the trigeminal ganglia. The mu -opioid receptor immunoreactivity was expressed in the small diameter FG- labeled TRG neurons. These results suggest that the activation of mu -opioid receptors inhibits the excitability of rat small diameter TRG neurons projecting on the superficial layer of the cervical dorsal horn and this inhibition is mediated by potentiation of voltage-dependent K super(+) currents. We therefore concluded that modulation of nociceptive transmission in the trigeminal system, resulting in the functional activation of mu -opioid receptors, occurs at the level of small TRG cell bodies and/or their primary afferent terminals, which contribute to opioid analgesia in the trigeminal pain. |
Author | Nasu, M Tanimoto, T Kadoi, J Matsumoto, S Takeda, M Ikeda, M |
Author_xml | – sequence: 1 givenname: M surname: Takeda fullname: Takeda, M email: m-takeda@tokyo.ndu.ac.jp organization: Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan – sequence: 2 givenname: T surname: Tanimoto fullname: Tanimoto, T organization: Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan – sequence: 3 givenname: M surname: Ikeda fullname: Ikeda, M organization: Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan – sequence: 4 givenname: J surname: Kadoi fullname: Kadoi, J organization: Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan – sequence: 5 givenname: M surname: Nasu fullname: Nasu, M organization: Research Center for Odontology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan – sequence: 6 givenname: S surname: Matsumoto fullname: Matsumoto, S organization: Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159 Japan |
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Cites_doi | 10.1016/0306-4522(93)90372-M 10.1016/S0006-8993(98)00332-1 10.1152/jn.00944.2001 10.1016/S0306-4522(01)00317-7 10.1152/jn.1989.62.3.810 10.1016/S0169-328X(99)00268-5 10.1113/jphysiol.1992.sp018932 10.1113/jphysiol.2002.017202 10.1038/38502 10.1111/j.1469-7793.2001.t01-1-00035.x 10.1016/0306-4522(96)00038-3 10.1113/jphysiol.1985.sp015573 10.1126/science.270.5240.1366 10.1073/pnas.94.4.1544 10.1152/physrev.2001.81.1.299 10.1152/jn.1998.79.2.677 10.1016/S0014-5793(96)01126-X 10.1523/JNEUROSCI.18-20-08153.1998 10.1007/s002210050742 10.1152/jn.1999.82.2.700 10.1016/0304-3959(95)00026-O 10.1679/aohc.61.83 10.1006/abio.1994.1581 10.1523/JNEUROSCI.23-01-00034.2003 10.1016/0304-3940(94)90815-X 10.1002/cne.901860202 10.1016/j.neuroscience.2003.09.022 10.1016/0306-4522(94)90571-1 10.1016/S0306-4522(02)00481-5 10.1152/jn.1996.75.6.2629 10.1073/pnas.231376298 10.1126/science.3764416 10.1152/jn.1998.79.4.1814 10.1113/jphysiol.1996.sp021152 10.1016/S0006-8993(96)00821-9 10.1016/S0306-4522(98)00409-6 10.1016/S0167-0115(02)00036-8 10.1038/383819a0 10.1016/S0024-3205(99)00150-2 10.1016/0304-3959(92)90248-A 10.1016/S0304-3959(00)00256-6 10.1152/jn.1998.79.5.2593 10.1523/JNEUROSCI.15-12-08011.1995 10.1007/s002210050850 10.1007/978-3-642-77540-6_3 10.1208/ps040208 10.1523/JNEUROSCI.18-11-04001.1998 10.1523/JNEUROSCI.14-03-01646.1994 10.1054/jpai.2000.9823 10.1002/cne.1086 10.1152/jn.2002.88.4.1614 10.1177/10454411000110010401 10.1152/jn.2000.84.2.1050 10.1113/jphysiol.1992.sp019149 |
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Keywords | FG DAMGO TRG Kv CTOP RT-PCR TTX immunohistochemistry trigeminal root ganglion PBS DTx I A EDTA I D PIPES SpVc μ-opioid receptor EGTA retrograde-labeling 4-AP TEA voltage-dependent K + channel I K HEPES SpVi DRG GAPDH Immunohistochemistry Spinal cord Rat Rodentia Central nervous system μ Opioid receptor Excitability Projection Ionic channel Posterior spinal horn Polymerase chain reaction Ganglion neuron Vertebrata Mammalia Animal voltage-dependent K+ channel Trigeminal ganglion Potassium |
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References | Ficker, Heinemann (BIB12) 1992; 445 Kieffer (BIB24) 2000; 1 Borgland, Connor, Christie (BIB5) 2001; 536 Hille (BIB19) 2001 Mo, Adamson, Davis (BIB33) 2002; 542 Akins, McCleskey (BIB2) 1993; 56 Debanne, Guerineau, Gahwiler, Thompson (BIB9) 1997; 389 Bereiter, Bereiter (BIB4) 1996; 73 Takeda, Tanimoto, Ikeda, Kadoi, Matsumoto (BIB52) 2004; 123 Li, Keith, Evans (BIB27) 1996; 397 Meng, Hu, Bereiter (BIB31) 1998; 79 Puil, Miura, Spigelman (BIB39) 1989; 62 Takeda, Ikeda, Tanimoto, Lipski, Matsumoto (BIB51) 2002; 115 Wong, Anderson, Cheng, Riabowol (BIB57) 1994; 223 Takeda, Tanimoto, Matsumoto (BIB49) 1999; 128 Li, Ding, Li, Li, Nomura, Kaneko, Mizuno (BIB26) 1998; 794 Everill, Rizzo, Kocsis (BIB10) 1998; 79 Levy, Zochodne (BIB25) 2000; 86 Chiang, Hu, Hu, Dostrovsky, Sessle (BIB8) 2002; 88 Sessle (BIB43) 2000; 11 Hirata, Takeshita, Hu, Beeiter (BIB18) 2000; 84 Taddese, Nah, McCleskey (BIB47) 1995; 270 Phillips, Goodchild, Dubey, Sesiaashvili, Takeda, Chalmers, Pilowsky, Lipski (BIB38) 2001; 431 Raynor, Kong, Chen, Yasuda, Yu, Bell, Reisine (BIB40) 1994; 45 Light, Perl (BIB28) 1979; 186 Brew, Forsythe (BIB6) 1995; 15 Yaksh (BIB53) 1993 Hori, Endo, Takahashi (BIB20) 1992; 450 Sugiura, Lee, Perl (BIB46) 1986; 234 Everill, Kocsis (BIB11) 1999; 82 Goldstein, Naidu (BIB14) 1989; 36 Silbert, Beacham, McCleskey (BIB41) 2003; 23 Angus-Leppan, Olausson, Boers, Lambert (BIB3) 1994; 182 Jarolimek, Bäurle, Misgeld (BIB23) 1998; 18 Budai, Fields (BIB7) 1998; 79 Osborne, Vaughan, Wilson, Christie (BIB34) 1996; 490 Abbadie, Pasternak, Aicher (BIB1) 2001; 106 Hu, Li (BIB21) 1996; 739 Mokha (BIB32) 1992; 49 Grudt, Williams (BIB15) 1994; 14 Matsumoto, Takeda, Tanimoto (BIB29) 1999; 126 Hu, Chiang, Hu, Dostrovsky, Sessle (BIB22) 2002; 88 Gold, Shuster, Levine (BIB13) 1996; 75 Takeda, Dubey, Phillips, Matsumoto, Lipski (BIB50) 2002; 106 Takeda, Tanimoto, Matsumoto (BIB48) 1998; 61 Wu, Barish (BIB58) 1992; 12 Sora, Takahashi, Funada, Ujike, Revay, Conovan, Miner, Uhl (BIB45) 1997; 94 Han, Cho, Kim, Min, Rhee, Akaike (BIB16) 1999; 90 Razook, Chandler, Forman (BIB37) 1995; 63 Xie, Meuser, Pietruck, Sharma, Palmer (BIB54) 1999; 64 Wang, Lee, Brazeau, Fung (BIB55) 2002; 4 Seifert, Kuprijanova, Zhou, Steinhuser (BIB42) 1999; 74 Harper, Lawson (BIB17) 1985; 359 Pearce, Duchen (BIB35) 1994; 63 Matthes, Maldonado, Simonin, Valverde, Slowe, Kitchen, Befort, Dierich, Le Meur, Dolle, Tzavara, Hanoune, Roques, Kieffer (BIB30) 1996; 383 Rasband, Park, Vanderah, Lai, Porreca, Timmer (BIB36) 2001; 98 Sodickson, Bean (BIB44) 1998; 18 Williams, Christie, Manzoni (BIB56) 2001; 81 Raynor (10.1016/j.neuroscience.2004.02.029_BIB40) 1994; 45 Takeda (10.1016/j.neuroscience.2004.02.029_BIB50) 2002; 106 Borgland (10.1016/j.neuroscience.2004.02.029_BIB5) 2001; 536 Matsumoto (10.1016/j.neuroscience.2004.02.029_BIB29) 1999; 126 Harper (10.1016/j.neuroscience.2004.02.029_BIB17) 1985; 359 Angus-Leppan (10.1016/j.neuroscience.2004.02.029_BIB3) 1994; 182 Everill (10.1016/j.neuroscience.2004.02.029_BIB10) 1998; 79 Akins (10.1016/j.neuroscience.2004.02.029_BIB2) 1993; 56 Williams (10.1016/j.neuroscience.2004.02.029_BIB56) 2001; 81 Brew (10.1016/j.neuroscience.2004.02.029_BIB6) 1995; 15 Goldstein (10.1016/j.neuroscience.2004.02.029_BIB14) 1989; 36 Mokha (10.1016/j.neuroscience.2004.02.029_BIB32) 1992; 49 Taddese (10.1016/j.neuroscience.2004.02.029_BIB47) 1995; 270 Hori (10.1016/j.neuroscience.2004.02.029_BIB20) 1992; 450 Hille (10.1016/j.neuroscience.2004.02.029_BIB19) 2001 Bereiter (10.1016/j.neuroscience.2004.02.029_BIB4) 1996; 73 Levy (10.1016/j.neuroscience.2004.02.029_BIB25) 2000; 86 Abbadie (10.1016/j.neuroscience.2004.02.029_BIB1) 2001; 106 Rasband (10.1016/j.neuroscience.2004.02.029_BIB36) 2001; 98 Wang (10.1016/j.neuroscience.2004.02.029_BIB55) 2002; 4 Hu (10.1016/j.neuroscience.2004.02.029_BIB22) 2002; 88 Xie (10.1016/j.neuroscience.2004.02.029_BIB54) 1999; 64 Puil (10.1016/j.neuroscience.2004.02.029_BIB39) 1989; 62 Li (10.1016/j.neuroscience.2004.02.029_BIB27) 1996; 397 Grudt (10.1016/j.neuroscience.2004.02.029_BIB15) 1994; 14 Debanne (10.1016/j.neuroscience.2004.02.029_BIB9) 1997; 389 Takeda (10.1016/j.neuroscience.2004.02.029_BIB51) 2002; 115 Yaksh (10.1016/j.neuroscience.2004.02.029_BIB53) 1993 Meng (10.1016/j.neuroscience.2004.02.029_BIB31) 1998; 79 Wong (10.1016/j.neuroscience.2004.02.029_BIB57) 1994; 223 Mo (10.1016/j.neuroscience.2004.02.029_BIB33) 2002; 542 Phillips (10.1016/j.neuroscience.2004.02.029_BIB38) 2001; 431 Chiang (10.1016/j.neuroscience.2004.02.029_BIB8) 2002; 88 Li (10.1016/j.neuroscience.2004.02.029_BIB26) 1998; 794 Pearce (10.1016/j.neuroscience.2004.02.029_BIB35) 1994; 63 Hu (10.1016/j.neuroscience.2004.02.029_BIB21) 1996; 739 Osborne (10.1016/j.neuroscience.2004.02.029_BIB34) 1996; 490 Everill (10.1016/j.neuroscience.2004.02.029_BIB11) 1999; 82 Budai (10.1016/j.neuroscience.2004.02.029_BIB7) 1998; 79 Light (10.1016/j.neuroscience.2004.02.029_BIB28) 1979; 186 Gold (10.1016/j.neuroscience.2004.02.029_BIB13) 1996; 75 Takeda (10.1016/j.neuroscience.2004.02.029_BIB49) 1999; 128 Wu (10.1016/j.neuroscience.2004.02.029_BIB58) 1992; 12 Takeda (10.1016/j.neuroscience.2004.02.029_BIB52) 2004; 123 Hirata (10.1016/j.neuroscience.2004.02.029_BIB18) 2000; 84 Silbert (10.1016/j.neuroscience.2004.02.029_BIB41) 2003; 23 Ficker (10.1016/j.neuroscience.2004.02.029_BIB12) 1992; 445 Sodickson (10.1016/j.neuroscience.2004.02.029_BIB44) 1998; 18 Takeda (10.1016/j.neuroscience.2004.02.029_BIB48) 1998; 61 Sessle (10.1016/j.neuroscience.2004.02.029_BIB43) 2000; 11 Jarolimek (10.1016/j.neuroscience.2004.02.029_BIB23) 1998; 18 Razook (10.1016/j.neuroscience.2004.02.029_BIB37) 1995; 63 Han (10.1016/j.neuroscience.2004.02.029_BIB16) 1999; 90 Sugiura (10.1016/j.neuroscience.2004.02.029_BIB46) 1986; 234 Seifert (10.1016/j.neuroscience.2004.02.029_BIB42) 1999; 74 Kieffer (10.1016/j.neuroscience.2004.02.029_BIB24) 2000; 1 Sora (10.1016/j.neuroscience.2004.02.029_BIB45) 1997; 94 Matthes (10.1016/j.neuroscience.2004.02.029_BIB30) 1996; 383 |
References_xml | – volume: 431 start-page: 20 year: 2001 end-page: 34 ident: BIB38 article-title: Differential expression of catecholamine biosynthetic enzymes in the rat ventrolateral medulla publication-title: J Comp Neurol contributor: fullname: Lipski – volume: 12 start-page: 2235 year: 1992 end-page: 2246 ident: BIB58 article-title: Two pharmacologically and kinetically distinct transient potassium currents in cultured embryonic mouse hippocampal neurons publication-title: J Neurophysiol contributor: fullname: Barish – volume: 115 start-page: 731 year: 2002 end-page: 741 ident: BIB51 article-title: Changes of the excitability of rat trigeminal root ganglion neurons evoked by α publication-title: Neuroscience contributor: fullname: Matsumoto – volume: 223 start-page: 251 year: 1994 end-page: 258 ident: BIB57 article-title: Monitoring mRNA expression by polymerase chain reaction publication-title: Anal Biochem contributor: fullname: Riabowol – volume: 389 start-page: 286 year: 1997 end-page: 289 ident: BIB9 article-title: Action-potential propagation gated by an axonal I publication-title: Nature contributor: fullname: Thompson – volume: 74 start-page: 55 year: 1999 end-page: 68 ident: BIB42 article-title: Developmental changes in the expression of Shaker- and Shab-related K publication-title: Mol Brain Res contributor: fullname: Steinhuser – volume: 98 start-page: 13373 year: 2001 end-page: 13378 ident: BIB36 article-title: Distinct potassium channels on pain-sensing neurons publication-title: Proc Natl Acad Sci USA contributor: fullname: Timmer – volume: 63 start-page: 1041 year: 1994 end-page: 1056 ident: BIB35 article-title: Differential expression of membrane currents in dissociated mouse primary sensory neurons publication-title: Neuroscience contributor: fullname: Duchen – volume: 88 start-page: 1614 year: 2002 end-page: 1624 ident: BIB22 article-title: P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis publication-title: J Neurophysiol contributor: fullname: Sessle – volume: 383 start-page: 819 year: 1996 end-page: 823 ident: BIB30 article-title: Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene publication-title: Nature contributor: fullname: Kieffer – volume: 542 start-page: 763 year: 2002 end-page: 778 ident: BIB33 article-title: Dendrotoxin-sensitive K publication-title: J Physiol (Lond) contributor: fullname: Davis – volume: 182 start-page: 275 year: 1994 end-page: 278 ident: BIB3 article-title: Convergence of afferents from superior sagittal sinus and tooth pulp on cells in the upper cervical spinal cord of the cat publication-title: Neurosci Lett contributor: fullname: Lambert – volume: 49 start-page: 405 year: 1992 end-page: 413 ident: BIB32 article-title: Differential influence of naloxone on the responses of nociceptive neurons in the superficial versus the deeper dorsal horn of medulla in the rat publication-title: Pain contributor: fullname: Mokha – volume: 75 start-page: 2629 year: 1996 end-page: 2646 ident: BIB13 article-title: Characterizaion of six voltage K publication-title: J Neurophysiol contributor: fullname: Levine – volume: 126 start-page: 351 year: 1999 end-page: 358 ident: BIB29 article-title: Effects of electrical stimulation of the tooth pulp and phrenic nerve fibers on C publication-title: Exp Brain Res contributor: fullname: Tanimoto – volume: 36 start-page: 265 year: 1989 end-page: 272 ident: BIB14 article-title: Multiple opioid receptors publication-title: Mol Pharmacol contributor: fullname: Naidu – volume: 270 start-page: 1366 year: 1995 end-page: 1369 ident: BIB47 article-title: Selective opioid inhibition of small nociceptive neurons publication-title: Science contributor: fullname: McCleskey – start-page: 134 year: 2001 end-page: 167 ident: BIB19 article-title: Potassium channels and chloride channels publication-title: Ion channels of excitable membranes, 3rd edition contributor: fullname: Hille – volume: 128 start-page: 303 year: 1999 end-page: 308 ident: BIB49 article-title: Effects of publication-title: Exp Brain Res contributor: fullname: Matsumoto – volume: 82 start-page: 700 year: 1999 end-page: 708 ident: BIB11 article-title: Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy publication-title: J Neurophysiol contributor: fullname: Kocsis – volume: 1 start-page: 45 year: 2000 end-page: 50 ident: BIB24 article-title: Opioid receptors publication-title: J Pain contributor: fullname: Kieffer – volume: 79 start-page: 2593 year: 1998 end-page: 2602 ident: BIB31 article-title: Differential effects of morphine on corneal-responsive neurons in rostral verses caudal regions of spinal trigeminal nucleus in the rat publication-title: J Neurophysiol contributor: fullname: Bereiter – volume: 536 start-page: 35 year: 2001 end-page: 47 ident: BIB5 article-title: Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse publication-title: J Physiol (Lond) contributor: fullname: Christie – volume: 450 start-page: 673 year: 1992 end-page: 685 ident: BIB20 article-title: Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord publication-title: J Physiol (Lond) contributor: fullname: Takahashi – volume: 79 start-page: 1814 year: 1998 end-page: 1824 ident: BIB10 article-title: Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying properties publication-title: J Neurophysiol contributor: fullname: Kocsis – volume: 86 start-page: 265 year: 2000 end-page: 271 ident: BIB25 article-title: Increased mRNA expression of B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain publication-title: Pain contributor: fullname: Zochodne – volume: 186 start-page: 117 year: 1979 end-page: 132 ident: BIB28 article-title: Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of course and fine fibers publication-title: J Comp Neurol contributor: fullname: Perl – volume: 15 start-page: 8011 year: 1995 end-page: 8022 ident: BIB6 article-title: Two voltage-dependent K publication-title: J Neurosci contributor: fullname: Forsythe – volume: 73 start-page: 249 year: 1996 end-page: 258 ident: BIB4 article-title: publication-title: Neuroscience contributor: fullname: Bereiter – volume: 79 start-page: 677 year: 1998 end-page: 687 ident: BIB7 article-title: Endogenous opioid peptides acting at μ-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons publication-title: J Neurophysiol contributor: fullname: Fields – volume: 106 start-page: 55 year: 2002 end-page: 65 ident: BIB50 article-title: Effects of vasopressin on isolated rat adrenal chromaffin cells publication-title: Regul Peptides contributor: fullname: Lipski – volume: 18 start-page: 8153 year: 1998 end-page: 8162 ident: BIB44 article-title: Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons publication-title: J Neurosci contributor: fullname: Bean – volume: 4 start-page: 1 year: 2002 end-page: 11 ident: BIB55 article-title: cDNA microarray analysis of vascular gene expression after nitric oxide donor infusions in rats publication-title: AAPS Pharm Sci contributor: fullname: Fung – volume: 359 start-page: 31 year: 1985 end-page: 46 ident: BIB17 article-title: Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons publication-title: J Physiol (Lond) contributor: fullname: Lawson – volume: 84 start-page: 1050 year: 2000 end-page: 1061 ident: BIB18 article-title: Cornea-responsive medullary dorsal horn neurons publication-title: J Neurophysiol contributor: fullname: Beeiter – volume: 45 start-page: 330 year: 1994 end-page: 334 ident: BIB40 article-title: Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors publication-title: Mol Pharmacol contributor: fullname: Reisine – volume: 88 start-page: 256 year: 2002 end-page: 264 ident: BIB8 article-title: Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on the integrity of subnucleus caudalis publication-title: J Neurophysiol contributor: fullname: Sessle – volume: 106 start-page: 833 year: 2001 end-page: 842 ident: BIB1 article-title: Presynaptic localization of the carboxy-terminus epitopes of the μopioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord publication-title: Neuroscience contributor: fullname: Aicher – start-page: 53 year: 1993 end-page: 90 ident: BIB53 article-title: The spinal actions of opioids publication-title: Opioid: II, Handbook of experimental pharmacology, Vol. 104 contributor: fullname: Yaksh – volume: 81 start-page: 299 year: 2001 end-page: 343 ident: BIB56 article-title: Cellular and synaptic adaptations mediating opioid dependence publication-title: Physiol Rev contributor: fullname: Manzoni – volume: 397 start-page: 25 year: 1996 end-page: 29 ident: BIB27 article-title: Multiple opioid receptor-like gene are identified in diverse vertebrate phyla publication-title: FEBS Lett contributor: fullname: Evans – volume: 23 start-page: 34 year: 2003 end-page: 42 ident: BIB41 article-title: Quantitative single cell differences in μ-opioid receptor mRNA distinguish myelinated and unmyelinated nociceptors publication-title: J Neurosci contributor: fullname: McCleskey – volume: 56 start-page: 759 year: 1993 end-page: 769 ident: BIB2 article-title: Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP publication-title: Neuroscience contributor: fullname: McCleskey – volume: 90 start-page: 209 year: 1999 end-page: 219 ident: BIB16 article-title: μ-Opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons publication-title: Neuroscience contributor: fullname: Akaike – volume: 794 start-page: 347 year: 1998 end-page: 352 ident: BIB26 article-title: Immunohistochemical localization of μ-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide publication-title: Brain Res contributor: fullname: Mizuno – volume: 14 start-page: 1646 year: 1994 end-page: 1654 ident: BIB15 article-title: μ-Opioid agonists inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat publication-title: J Neurosci contributor: fullname: Williams – volume: 64 start-page: 2028 year: 1999 end-page: 2037 ident: BIB54 article-title: Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia publication-title: Life Sci contributor: fullname: Palmer – volume: 63 start-page: 117 year: 1995 end-page: 125 ident: BIB37 article-title: Phrenic afferent input excites C1-C2 spinal neurons in rats publication-title: Pain contributor: fullname: Forman – volume: 445 start-page: 431 year: 1992 end-page: 455 ident: BIB12 article-title: Slow and fast transient potassium currents in cultured rat hippocampal cells publication-title: J Physiol (Lond) contributor: fullname: Heinemann – volume: 490 start-page: 383 year: 1996 end-page: 389 ident: BIB34 article-title: Opioid inhibition of rat periaqueductal grey neurons with identified projections to rostral ventromedial medulla in vitro publication-title: J Physiol (Lond) contributor: fullname: Christie – volume: 62 start-page: 810 year: 1989 end-page: 820 ident: BIB39 article-title: Consequences of 4-aminopyridine applications to trigeminal root ganglion neurons publication-title: J Neurophysiol contributor: fullname: Spigelman – volume: 234 start-page: 358 year: 1986 end-page: 361 ident: BIB46 article-title: Central projections of identified unmyelinated (C) afferents fibers innervating mammalian skin publication-title: Science contributor: fullname: Perl – volume: 11 start-page: 57 year: 2000 end-page: 91 ident: BIB43 article-title: Acute and chronic craniofacial pain publication-title: Crit Rev Oral Biol Med contributor: fullname: Sessle – volume: 61 start-page: 83 year: 1998 end-page: 87 ident: BIB48 article-title: C-fos like immunoreactive in the upper cervical spinal dorsal horn neurons following noxious chemical stimulation of the nasal mucosa in pentobarbital rats publication-title: Arch Histol Cytol contributor: fullname: Matsumoto – volume: 94 start-page: 1544 year: 1997 end-page: 1549 ident: BIB45 article-title: Opiate receptor knockout mice define μ-opioid receptor roles in endogenous nociceptive responses and morphine-induced analgesia publication-title: Proc Natl Acad Sci USA contributor: fullname: Uhl – volume: 18 start-page: 4001 year: 1998 end-page: 4007 ident: BIB23 article-title: Pore mutation in a G-protein-gated inwardly rectifying K publication-title: J Neurosci contributor: fullname: Misgeld – volume: 739 start-page: 163 year: 1996 end-page: 168 ident: BIB21 article-title: Substance P potentiates ATP-activated currents on rat primary sensory neurons publication-title: Brain Res contributor: fullname: Li – volume: 123 start-page: 491 year: 2004 end-page: 505 ident: BIB52 article-title: Activation of GABA publication-title: Neuroscience contributor: fullname: Matsumoto – volume: 56 start-page: 759 year: 1993 ident: 10.1016/j.neuroscience.2004.02.029_BIB2 article-title: Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP publication-title: Neuroscience doi: 10.1016/0306-4522(93)90372-M contributor: fullname: Akins – volume: 794 start-page: 347 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB26 article-title: Immunohistochemical localization of μ-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide publication-title: Brain Res doi: 10.1016/S0006-8993(98)00332-1 contributor: fullname: Li – volume: 88 start-page: 256 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB8 article-title: Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on the integrity of subnucleus caudalis publication-title: J Neurophysiol doi: 10.1152/jn.00944.2001 contributor: fullname: Chiang – volume: 106 start-page: 833 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB1 article-title: Presynaptic localization of the carboxy-terminus epitopes of the μopioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord publication-title: Neuroscience doi: 10.1016/S0306-4522(01)00317-7 contributor: fullname: Abbadie – volume: 62 start-page: 810 year: 1989 ident: 10.1016/j.neuroscience.2004.02.029_BIB39 article-title: Consequences of 4-aminopyridine applications to trigeminal root ganglion neurons publication-title: J Neurophysiol doi: 10.1152/jn.1989.62.3.810 contributor: fullname: Puil – volume: 74 start-page: 55 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB42 article-title: Developmental changes in the expression of Shaker- and Shab-related K+ channels in neurons of rat trigeminal ganglion publication-title: Mol Brain Res doi: 10.1016/S0169-328X(99)00268-5 contributor: fullname: Seifert – volume: 445 start-page: 431 year: 1992 ident: 10.1016/j.neuroscience.2004.02.029_BIB12 article-title: Slow and fast transient potassium currents in cultured rat hippocampal cells publication-title: J Physiol (Lond) doi: 10.1113/jphysiol.1992.sp018932 contributor: fullname: Ficker – volume: 542 start-page: 763 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB33 article-title: Dendrotoxin-sensitive K+ currents contribute to accommodation murine spiral ganglion neurons publication-title: J Physiol (Lond) doi: 10.1113/jphysiol.2002.017202 contributor: fullname: Mo – volume: 389 start-page: 286 year: 1997 ident: 10.1016/j.neuroscience.2004.02.029_BIB9 article-title: Action-potential propagation gated by an axonal IA-like K+ conductance in hippocampus publication-title: Nature doi: 10.1038/38502 contributor: fullname: Debanne – volume: 536 start-page: 35 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB5 article-title: Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse publication-title: J Physiol (Lond) doi: 10.1111/j.1469-7793.2001.t01-1-00035.x contributor: fullname: Borgland – volume: 73 start-page: 249 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB4 article-title: N-methyl-d-aspartate and non-N-methyl-aspartate receptor antagonism reduces fos-like immunoreactivity in central trigeminal neurons after corneal stimulation in the rat publication-title: Neuroscience doi: 10.1016/0306-4522(96)00038-3 contributor: fullname: Bereiter – volume: 359 start-page: 31 year: 1985 ident: 10.1016/j.neuroscience.2004.02.029_BIB17 article-title: Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons publication-title: J Physiol (Lond) doi: 10.1113/jphysiol.1985.sp015573 contributor: fullname: Harper – volume: 270 start-page: 1366 year: 1995 ident: 10.1016/j.neuroscience.2004.02.029_BIB47 article-title: Selective opioid inhibition of small nociceptive neurons publication-title: Science doi: 10.1126/science.270.5240.1366 contributor: fullname: Taddese – volume: 94 start-page: 1544 year: 1997 ident: 10.1016/j.neuroscience.2004.02.029_BIB45 article-title: Opiate receptor knockout mice define μ-opioid receptor roles in endogenous nociceptive responses and morphine-induced analgesia publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.4.1544 contributor: fullname: Sora – volume: 81 start-page: 299 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB56 article-title: Cellular and synaptic adaptations mediating opioid dependence publication-title: Physiol Rev doi: 10.1152/physrev.2001.81.1.299 contributor: fullname: Williams – volume: 79 start-page: 677 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB7 article-title: Endogenous opioid peptides acting at μ-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons publication-title: J Neurophysiol doi: 10.1152/jn.1998.79.2.677 contributor: fullname: Budai – volume: 397 start-page: 25 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB27 article-title: Multiple opioid receptor-like gene are identified in diverse vertebrate phyla publication-title: FEBS Lett doi: 10.1016/S0014-5793(96)01126-X contributor: fullname: Li – volume: 18 start-page: 8153 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB44 article-title: Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-20-08153.1998 contributor: fullname: Sodickson – volume: 126 start-page: 351 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB29 article-title: Effects of electrical stimulation of the tooth pulp and phrenic nerve fibers on C1 spinal neurons in the rat publication-title: Exp Brain Res doi: 10.1007/s002210050742 contributor: fullname: Matsumoto – volume: 82 start-page: 700 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB11 article-title: Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy publication-title: J Neurophysiol doi: 10.1152/jn.1999.82.2.700 contributor: fullname: Everill – volume: 63 start-page: 117 year: 1995 ident: 10.1016/j.neuroscience.2004.02.029_BIB37 article-title: Phrenic afferent input excites C1-C2 spinal neurons in rats publication-title: Pain doi: 10.1016/0304-3959(95)00026-O contributor: fullname: Razook – volume: 61 start-page: 83 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB48 article-title: C-fos like immunoreactive in the upper cervical spinal dorsal horn neurons following noxious chemical stimulation of the nasal mucosa in pentobarbital rats publication-title: Arch Histol Cytol doi: 10.1679/aohc.61.83 contributor: fullname: Takeda – volume: 223 start-page: 251 year: 1994 ident: 10.1016/j.neuroscience.2004.02.029_BIB57 article-title: Monitoring mRNA expression by polymerase chain reaction publication-title: Anal Biochem doi: 10.1006/abio.1994.1581 contributor: fullname: Wong – volume: 23 start-page: 34 year: 2003 ident: 10.1016/j.neuroscience.2004.02.029_BIB41 article-title: Quantitative single cell differences in μ-opioid receptor mRNA distinguish myelinated and unmyelinated nociceptors publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-01-00034.2003 contributor: fullname: Silbert – volume: 182 start-page: 275 year: 1994 ident: 10.1016/j.neuroscience.2004.02.029_BIB3 article-title: Convergence of afferents from superior sagittal sinus and tooth pulp on cells in the upper cervical spinal cord of the cat publication-title: Neurosci Lett doi: 10.1016/0304-3940(94)90815-X contributor: fullname: Angus-Leppan – volume: 186 start-page: 117 year: 1979 ident: 10.1016/j.neuroscience.2004.02.029_BIB28 article-title: Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of course and fine fibers publication-title: J Comp Neurol doi: 10.1002/cne.901860202 contributor: fullname: Light – volume: 123 start-page: 491 year: 2004 ident: 10.1016/j.neuroscience.2004.02.029_BIB52 article-title: Activation of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons publication-title: Neuroscience doi: 10.1016/j.neuroscience.2003.09.022 contributor: fullname: Takeda – volume: 36 start-page: 265 year: 1989 ident: 10.1016/j.neuroscience.2004.02.029_BIB14 article-title: Multiple opioid receptors publication-title: Mol Pharmacol contributor: fullname: Goldstein – volume: 63 start-page: 1041 year: 1994 ident: 10.1016/j.neuroscience.2004.02.029_BIB35 article-title: Differential expression of membrane currents in dissociated mouse primary sensory neurons publication-title: Neuroscience doi: 10.1016/0306-4522(94)90571-1 contributor: fullname: Pearce – volume: 115 start-page: 731 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB51 article-title: Changes of the excitability of rat trigeminal root ganglion neurons evoked by α2-adrenoreceptors publication-title: Neuroscience doi: 10.1016/S0306-4522(02)00481-5 contributor: fullname: Takeda – volume: 75 start-page: 2629 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB13 article-title: Characterizaion of six voltage K+ currents in adult rat sensory neurons publication-title: J Neurophysiol doi: 10.1152/jn.1996.75.6.2629 contributor: fullname: Gold – volume: 98 start-page: 13373 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB36 article-title: Distinct potassium channels on pain-sensing neurons publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.231376298 contributor: fullname: Rasband – volume: 234 start-page: 358 year: 1986 ident: 10.1016/j.neuroscience.2004.02.029_BIB46 article-title: Central projections of identified unmyelinated (C) afferents fibers innervating mammalian skin publication-title: Science doi: 10.1126/science.3764416 contributor: fullname: Sugiura – volume: 79 start-page: 1814 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB10 article-title: Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying properties publication-title: J Neurophysiol doi: 10.1152/jn.1998.79.4.1814 contributor: fullname: Everill – volume: 490 start-page: 383 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB34 article-title: Opioid inhibition of rat periaqueductal grey neurons with identified projections to rostral ventromedial medulla in vitro publication-title: J Physiol (Lond) doi: 10.1113/jphysiol.1996.sp021152 contributor: fullname: Osborne – volume: 45 start-page: 330 year: 1994 ident: 10.1016/j.neuroscience.2004.02.029_BIB40 article-title: Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors publication-title: Mol Pharmacol contributor: fullname: Raynor – volume: 739 start-page: 163 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB21 article-title: Substance P potentiates ATP-activated currents on rat primary sensory neurons publication-title: Brain Res doi: 10.1016/S0006-8993(96)00821-9 contributor: fullname: Hu – volume: 90 start-page: 209 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB16 article-title: μ-Opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons publication-title: Neuroscience doi: 10.1016/S0306-4522(98)00409-6 contributor: fullname: Han – volume: 106 start-page: 55 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB50 article-title: Effects of vasopressin on isolated rat adrenal chromaffin cells publication-title: Regul Peptides doi: 10.1016/S0167-0115(02)00036-8 contributor: fullname: Takeda – volume: 383 start-page: 819 year: 1996 ident: 10.1016/j.neuroscience.2004.02.029_BIB30 article-title: Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene publication-title: Nature doi: 10.1038/383819a0 contributor: fullname: Matthes – volume: 64 start-page: 2028 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB54 article-title: Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia publication-title: Life Sci doi: 10.1016/S0024-3205(99)00150-2 contributor: fullname: Xie – volume: 49 start-page: 405 year: 1992 ident: 10.1016/j.neuroscience.2004.02.029_BIB32 article-title: Differential influence of naloxone on the responses of nociceptive neurons in the superficial versus the deeper dorsal horn of medulla in the rat publication-title: Pain doi: 10.1016/0304-3959(92)90248-A contributor: fullname: Mokha – volume: 86 start-page: 265 year: 2000 ident: 10.1016/j.neuroscience.2004.02.029_BIB25 article-title: Increased mRNA expression of B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain publication-title: Pain doi: 10.1016/S0304-3959(00)00256-6 contributor: fullname: Levy – volume: 79 start-page: 2593 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB31 article-title: Differential effects of morphine on corneal-responsive neurons in rostral verses caudal regions of spinal trigeminal nucleus in the rat publication-title: J Neurophysiol doi: 10.1152/jn.1998.79.5.2593 contributor: fullname: Meng – volume: 15 start-page: 8011 year: 1995 ident: 10.1016/j.neuroscience.2004.02.029_BIB6 article-title: Two voltage-dependent K+ conductances with complementary functions in postsysnaptic integration at a central auditory synapses publication-title: J Neurosci doi: 10.1523/JNEUROSCI.15-12-08011.1995 contributor: fullname: Brew – volume: 128 start-page: 303 year: 1999 ident: 10.1016/j.neuroscience.2004.02.029_BIB49 article-title: Effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists on excitation of the tooth-pulp-evoked C1 spinal neurons in the rat publication-title: Exp Brain Res doi: 10.1007/s002210050850 contributor: fullname: Takeda – start-page: 53 year: 1993 ident: 10.1016/j.neuroscience.2004.02.029_BIB53 article-title: The spinal actions of opioids doi: 10.1007/978-3-642-77540-6_3 contributor: fullname: Yaksh – volume: 12 start-page: 2235 year: 1992 ident: 10.1016/j.neuroscience.2004.02.029_BIB58 article-title: Two pharmacologically and kinetically distinct transient potassium currents in cultured embryonic mouse hippocampal neurons publication-title: J Neurophysiol contributor: fullname: Wu – volume: 4 start-page: 1 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB55 article-title: cDNA microarray analysis of vascular gene expression after nitric oxide donor infusions in rats publication-title: AAPS Pharm Sci doi: 10.1208/ps040208 contributor: fullname: Wang – volume: 18 start-page: 4001 year: 1998 ident: 10.1016/j.neuroscience.2004.02.029_BIB23 article-title: Pore mutation in a G-protein-gated inwardly rectifying K+ channel subunit causes loss of K+-dependent inhibition in weaver hippocampus publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-11-04001.1998 contributor: fullname: Jarolimek – volume: 14 start-page: 1646 year: 1994 ident: 10.1016/j.neuroscience.2004.02.029_BIB15 article-title: μ-Opioid agonists inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat publication-title: J Neurosci doi: 10.1523/JNEUROSCI.14-03-01646.1994 contributor: fullname: Grudt – volume: 1 start-page: 45 year: 2000 ident: 10.1016/j.neuroscience.2004.02.029_BIB24 article-title: Opioid receptors publication-title: J Pain doi: 10.1054/jpai.2000.9823 contributor: fullname: Kieffer – start-page: 134 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB19 article-title: Potassium channels and chloride channels contributor: fullname: Hille – volume: 431 start-page: 20 year: 2001 ident: 10.1016/j.neuroscience.2004.02.029_BIB38 article-title: Differential expression of catecholamine biosynthetic enzymes in the rat ventrolateral medulla publication-title: J Comp Neurol doi: 10.1002/cne.1086 contributor: fullname: Phillips – volume: 88 start-page: 1614 year: 2002 ident: 10.1016/j.neuroscience.2004.02.029_BIB22 article-title: P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis publication-title: J Neurophysiol doi: 10.1152/jn.2002.88.4.1614 contributor: fullname: Hu – volume: 11 start-page: 57 year: 2000 ident: 10.1016/j.neuroscience.2004.02.029_BIB43 article-title: Acute and chronic craniofacial pain publication-title: Crit Rev Oral Biol Med doi: 10.1177/10454411000110010401 contributor: fullname: Sessle – volume: 84 start-page: 1050 year: 2000 ident: 10.1016/j.neuroscience.2004.02.029_BIB18 article-title: Cornea-responsive medullary dorsal horn neurons publication-title: J Neurophysiol doi: 10.1152/jn.2000.84.2.1050 contributor: fullname: Hirata – volume: 450 start-page: 673 year: 1992 ident: 10.1016/j.neuroscience.2004.02.029_BIB20 article-title: Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord publication-title: J Physiol (Lond) doi: 10.1113/jphysiol.1992.sp019149 contributor: fullname: Hori |
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Snippet | The aim of the present study was to investigate the effect of a μ-opioid receptor agonist DAMGO (Tyr-
d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of... The aim of the present study was to investigate the effect of a micro-opioid receptor agonist DAMGO (Tyr-d-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of... The aim of the present study was to investigate the effect of a mu -opioid receptor agonist DAMGO (Tyr-D-Ala-Gly-NMe-Phe-Gly-ol) on the excitability of... |
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SubjectTerms | Analgesics, Opioid - pharmacology Animals Biological and medical sciences Cervical Vertebrae Dose-Response Relationship, Drug Enkephalin, Ala-MePhe-Gly- - pharmacology Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Membrane Potentials - drug effects Neurons - metabolism Patch-Clamp Techniques Posterior Horn Cells - cytology Posterior Horn Cells - metabolism Potassium Channel Blockers - pharmacology Potassium Channels, Voltage-Gated - drug effects Potassium Channels, Voltage-Gated - metabolism Rats Receptors, Opioid, mu - agonists Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism retrograde-labeling Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RT-PCR Somatostatin - analogs & derivatives Somatostatin - pharmacology Trigeminal Ganglion - drug effects Trigeminal Ganglion - physiology trigeminal root ganglion Vertebrates: nervous system and sense organs voltage-dependent K + channel μ-opioid receptor |
Title | Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn |
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