Is renal tubular cadmium toxicity clinically relevant?

• Published in: Clinical kidney journal Vol. 11; no. 5; pp. 681 - 687
• Main Authors: Boonprasert, Kanyarat, Vesey, David A, Gobe, Glenda C, Ruenweerayut, Ronnatrai, Johnson, David W, Na-Bangchang, Kesara, Satarug, Soisungwan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2018
• Subjects: Blood pressure; Cadmium; Hypertension; Nephrotoxicity; Thailand; blood pressure; estimated glomerular filtration rate; renal tubular dysfunction; 20-hydroxyeicosatetraenoic acid; cadmium exposure; hypertension; β2-microglobulin

ABSTRACT Background Exposure to cadmium (Cd) has been associated with the development of hypertension, especially in women, but the mechanism of such an association is not understood. We hypothesize that Cd exposure alters renal production of 20-hydroxyeicosatetraenoic acid (20-HETE), which plays an...