B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha
Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyro...
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| Published in | Clinical & developmental immunology Vol. 2012; no. 2012; pp. 1 - 4 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Cairo, Egypt
Hindawi Puplishing Corporation
01.01.2012
Hindawi Publishing Corporation Hindawi Limited |
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| Abstract | Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyroid peroxidase antibody (anti-TPO) in CHC patients treated with pegylated interferon alpha and ribavirin combination therapy. Six months after the therapy, anti-TPO antibody was detected in 10 (males, 1; females, 9) of 50 patients. The mean age of these patients was higher than that of the anti-TPO-negative patients (61 yr versus 55 yr). Before treatment, the serum BAFF levels of the anti-TPO-positive patients were higher than those of the anti-TPO-negative patients. After starting therapy, the serum BAFF levels of both the anti-TPO-positive and -negative patient groups were elevated. Our findings suggest that the serum BAFF concentration before therapy can predict the risk of thyroid autoimmunity in elderly female patients with CHC. |
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| AbstractList | Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyroid peroxidase antibody (anti-TPO) in CHC patients treated with pegylated interferon alpha and ribavirin combination therapy. Six months after the therapy, anti-TPO antibody was detected in 10 (males, 1; females, 9) of 50 patients. The mean age of these patients was higher than that of the anti-TPO-negative patients (61 yr versus 55 yr). Before treatment, the serum BAFF levels of the anti-TPO-positive patients were higher than those of the anti-TPO-negative patients. After starting therapy, the serum BAFF levels of both the anti-TPO-positive and -negative patient groups were elevated. Our findings suggest that the serum BAFF concentration before therapy can predict the risk of thyroid autoimmunity in elderly female patients with CHC. |
| Author | Kajiyama, Yusuke Hoshino, Hiromi Hino, Kunihiko Kikuchi, Kentaro Takai, Atsuko Hosoya, Naomi Miyakawa, Hiroshi |
| AuthorAffiliation | 2 Central Laboratory, Teikyo University Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Kawasaki-shi, Kanagawa 213-8507, Japan 3 Delta Clinic, 2-5-1 Kusunokidai, Tokorozawa-shi, Saitama 359-0037, Japan 1 Fourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Kawasaki-shi, Kanagawa 213-8507, Japan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22481965$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S 10.1136/ard.62.2.168 10.1089/thy.1997.7.891 10.2169/internalmedicine.50.4790 10.1016/j.beem.2009.07.004 10.1038/35010115 10.4049/jimmunol.166.1.6 10.1016/j.ecl.2007.07.001 10.1002/jlb.65.5.680 10.1172/JCI200214121 10.1196/annals.1313.004 10.1016/S0016-5085(03)00394-9 10.1002/art.11354 10.1084/jem.189.11.1747 10.1074/jbc.274.23.15978 10.1126/science.285.5425.260 10.1016/j.amjmed.2004.01.023 10.1111/j.1365-2249.2009.04007.x 10.1002/hep.21146 10.1517/14728222.7.1.115 10.1016/j.amjmed.2004.04.004 10.1089/105072503322238809 |
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| Copyright | Copyright © 2012 Yusuke Kajiyama et al. Copyright © 2012 Yusuke Kajiyama et al. 2012 |
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| Snippet | Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study,... |
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| SubjectTerms | Age Factors Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Autoantibodies - biosynthesis Autoantibodies - blood Autoantibodies - immunology Autoimmunity - drug effects B-Cell Activating Factor - blood B-Cell Activating Factor - immunology Biomarkers - blood Drug Therapy, Combination Female Hepacivirus - drug effects Hepacivirus - immunology Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology Humans Interferon-alpha - administration & dosage Interferon-alpha - therapeutic use Male Middle Aged Peroxidase - blood Peroxidase - immunology Polyethylene Glycols - administration & dosage Polyethylene Glycols - therapeutic use Prognosis Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Ribavirin - administration & dosage Ribavirin - therapeutic use Sex Factors Thyroid Gland - drug effects Thyroid Gland - immunology Thyroid Gland - pathology |
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| Title | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
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