Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 51; pp. E5555 - E5563
• Main Authors: Yeaman, Michael R, Filler, Scott G, Chaili, Siyang, Barr, Kevin, Wang, Huiyuan, Kupferwasser, Deborah, Hennessey, Jr, John P, Fu, Yue, Schmidt, Clint S, Edwards, Jr, John E, Xiong, Yan Q, Ibrahim, Ashraf S
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.12.2014; National Acad Sciences
• Series: PNAS Plus
• Subjects: Adaptive Immunity; Animals; Antigens; Bacterial Vaccines - therapeutic use; Biological Sciences; Comparative analysis; Disease Models, Animal; Glycoproteins; Interleukin-17 - metabolism; Interleukin-22; Interleukins - metabolism; Mice; PNAS Plus; Skin Diseases, Bacterial - therapy; Staphylococcal Infections - prevention & control; Staphylococcus aureus; Staphylococcus infections; T cell receptors; T-Lymphocytes - immunology; Vaccines; skin; vaccine; Th22; Th17; Staphylococcus aureus

Significance Staphylococcus aureus is an opportunistic pathogen of the normal human flora. It is among the most frequent causes of cutaneous abscesses, leading to life-threatening invasive infection. Incomplete understanding of host defenses against S. aureus skin or invasive infection has hindered...