Recombinant viral hemorrhagic septicemia virus with rearranged genomes as vaccine vectors to protect against lethal betanodavirus infection

• Published in: Frontiers in immunology Vol. 14; p. 1138961
• Main Authors: Souto, Sandra, Mérour, Emilie, Le Coupanec, Alain, Lamoureux, Annie, Bernard, Julie, Brémont, Michel, Millet, Jean K., Biacchesi, Stéphane
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 14.03.2023; Frontiers Media S.A
• Subjects: Animals; Antigens; betanodavirus; Glycoproteins; Hemorrhagic Septicemia, Viral; Immunology; Life Sciences; live attenuated vaccine; NNV; Nodaviridae - genetics; Novirhabdovirus; trout; Vaccines; VHSV; live attenuated vaccine; sole; NNV; trout; Novirhabdovirus; betanodavirus; VHSV; troutsole

The outbreaks of viral hemorrhagic septicemia (VHS) and viral encephalopathy and retinopathy (VER) caused by the enveloped novirhabdovirus VHSV, and the non-enveloped betanodavirus nervous necrosis virus (NNV), respectively, represent two of the main viral infectious threats for aquaculture worldwid...