Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues

• Published in: European journal of nutrition Vol. 58; no. 2; pp. 743 - 753
• Main Authors: Lesjak, Marija, Balesaria, Sara, Skinner, Vernon, Debnam, Edward S., Srai, Surjit Kaila S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2019; Springer Nature B.V
• Subjects: Anemia; Animals; Antioxidants - pharmacology; blood serum; Chemistry; Chemistry and Materials Science; Divalent metal transporter-1; Duodenum - drug effects; Duodenum - metabolism; Gene expression; Gene Expression - drug effects; genes; Hepcidin; Intestinal Absorption - drug effects; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestine; intestines; Iron; Iron - metabolism; iron absorption; Iron deficiency; iron deficiency anemia; liquid chromatography; Liver; Male; Metabolism; Metabolites; Models, Animal; Mucosa; nutrient deficiencies; Nutrient deficiency; Nutrition; Original Contribution; Polyphenols; Quercetin; Quercetin - pharmacology; radiolabeling; Rats; Rats, Sprague-Dawley; Rodents; tandem mass spectrometry; transferrin; Transferrins; Polyphenols; Absorption; Duodenum; Non-haem iron; Quercetin; Iron deficiency anaemia

Purpose There is general agreement that some dietary polyphenols block non-haem iron uptake, but the mechanisms by which they achieve this action are poorly understood. Since the polyphenol quercetin is ingested daily in significant amounts, we have investigated the effect of quercetin on duodenal n...