The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy

• Published in: Blood Vol. 115; no. 5; pp. 1054 - 1061
• Main Authors: Dragani, Alfredo, Pascale, Silvia, Recchiuti, Antonio, Mattoscio, Domenico, Lattanzio, Stefano, Petrucci, Giovanna, Mucci, Luciana, Ferrante, Elisabetta, Habib, Aida, Ranelletti, Franco O., Ciabattoni, Giovanni, Davì, Giovanni, Patrono, Carlo, Rocca, Bianca
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 04.02.2010; Americain Society of Hematology
• Subjects: Adult; Aspirin - therapeutic use; Biological and medical sciences; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase Inhibitors - therapeutic use; Drug Therapy, Combination; Etoricoxib; Female; Hematologic and hematopoietic diseases; Humans; Immunohistochemistry; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Platelet Aggregation Inhibitors - therapeutic use; Pyridines - therapeutic use; Sulfones - therapeutic use; Thrombocythemia, Essential - drug therapy; Thrombocythemia, Essential - metabolism; Thrombocythemia, Essential - pathology; Thromboxane A2 - biosynthesis; Thromboxane A2 - blood; Thromboxane A2 - urine; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - biosynthesis; Thromboxane B2 - blood; Thromboxane B2 - urine; Thromboxanes - biosynthesis; Thromboxanes - blood; Thromboxanes - urine; Treatment Outcome; Prostaglandin-endoperoxide synthase; Hematology; Enzyme; Arachidonic acid derivatives; Cyclooxygenase 2; Cyclooxygenase 1; Enzyme inhibitor; Malignant hemopathy; Biosynthesis; Acetylsalicylic acid; Antiplatelet agent; Myeloproliferative syndrome; Essential thrombocythemia; Treatment; Eicosanoid; Oxidoreductases; Salicylates; Thromboxane; Cancer

We tested whether cyclooxygenase 2 (COX-2) expression and unacetylated COX-1 in newly formed platelets might contribute to persistent thromboxane (TX) biosynthesis in aspirin-treated essential thrombocythemia (ET). Forty-one patients on chronic aspirin (100 mg/day) and 24 healthy subjects were studi...