Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma

• Published in: Bulletin of experimental biology and medicine Vol. 154; no. 3; pp. 370 - 374
• Main Authors: Zhukova, N. A., Semenov, D. E., Bessergeneva, E. P., Sorokina, I. V., Tolstikova, T. G.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2013; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Chemical and Drug Induced Liver Injury - drug therapy; Internal Medicine; Laboratory Medicine; Liver - drug effects; Liver - pathology; Lymphoma - drug therapy; Mice; Mice, Inbred CBA; Mitosis - drug effects; Neoplasm Transplantation; Non-Hodgkin's lymphomas; Pathology; Triterpenes - pharmacology; Triterpenes - therapeutic use; 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15); betulin 3β,28-di-O-nicotinate (of3); RLS lymphoma metastases to mouse liver; hepatoprotective effect; polychemotherapy

The hepatoprotective effects of new triterpene derivatives, betulin 3β,28-di-O-nicotinate (of3) and 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15), were studied in CBA/Lac mice with transplanted RLS lymphoma receiving polychemotherapy and without it. Injection of of3 and of15 agents to anim...