A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis

• Published in: The Journal of biological chemistry Vol. 274; no. 4; pp. 2072 - 2076
• Main Authors: Seol, Dai-Wu, Billiar, Timothy R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.01.1999; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Apoptosis - physiology; Caspase 9; Caspases - genetics; Caspases - metabolism; Caspases - physiology; Catalytic Domain; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Liver - enzymology; Molecular Sequence Data; Sequence Homology, Amino Acid

It is likely that endogenous inhibitors of the apical caspases such as caspase-9 exist to prevent undesirable activation of caspase cascades. A naturally occurring variant of caspase-9 named caspase-9S was cloned from human liver. Caspase-9S is missing most of the large subunit of caspase-9, includi...