Measuring the impact of olive pomace enriched biscuits on the gut microbiota and its metabolic activity in mildly hypercholesterolaemic subjects

• Published in: European journal of nutrition Vol. 58; no. 1; pp. 63 - 81
• Main Authors: Conterno, Lorenza, Martinelli, Francesca, Tamburini, Matteo, Fava, Francesca, Mancini, Andrea, Sordo, Maddalena, Pindo, Massimo, Martens, Stefan, Masuero, Domenico, Vrhovsek, Urska, Dal Lago, Claudia, Ferrario, Gabriele, Morandini, Mario, Tuohy, Kieran
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019; Springer Nature B.V
• Subjects: Acids; Adult; Aged; bacteria; Bifidobacterium; biochemical pathways; Biscuits; blood; blood sampling; Bread; Chemistry; Chemistry and Materials Science; Cholesterol; Clinical trials; Dihydroxyphenylacetic acid; Double-Blind Method; feces; Female; Fluorescence in situ hybridization; Gastrointestinal Microbiome - drug effects; Gut microbiota; Homovanillic acid; Humans; hypercholesterolemia; Hypercholesterolemia - metabolism; Intestinal microflora; intestinal microorganisms; Lactobacillus; liquid chromatography; Low density lipoprotein; low density lipoprotein cholesterol; Male; mass spectrometry; men; Metabolism; Metabolites; Microbiota; Middle Aged; Nutrition; nutritional intervention; Olea - metabolism; Olive oil; olive pomace; olives; Original Contribution; oxidation; Plant Extracts - metabolism; Plant Extracts - pharmacology; Polyphenols; quantitative polymerase chain reaction; ribosomal RNA; rRNA 16S; Ruminococcus; Sex; Sex Factors; Statistical analysis; Urine; wastes; women; Polyphenols; Metabolomic; Olive product; Tyrosol glucoside; Prebiotic; Tyrosol group

Purpose Olive pomace is a major waste product of olive oil production but remains rich in polyphenols and fibres. We measured the potential of an olive pomace-enriched biscuit formulation delivering 17.1 ± 4.01 mg/100 g of hydroxytyrosol and its derivatives, to modulate the composition and metabolic...