Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

• Published in: The Journal of clinical investigation Vol. 121; no. 2; pp. 569 - 581
• Main Authors: Oh, Sungwhan F, Pillai, Padmini S, Recchiuti, Antonio, Yang, Rong, Serhan, Charles N
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.02.2011
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - immunology; Arachidonate 5-Lipoxygenase - genetics; Arachidonate 5-Lipoxygenase - metabolism; Aspirin; Aspirin - immunology; Biomedical research; Biosynthesis; Cyclooxygenase 2 - metabolism; E coli; Eicosapentaenoic Acid - analogs & derivatives; Eicosapentaenoic Acid - biosynthesis; Eicosapentaenoic Acid - blood; Enzymes; Fatty acids; Fatty Acids, Omega-3 - immunology; Fatty Acids, Omega-3 - metabolism; Fish Oils - administration & dosage; Fish Oils - chemistry; Homeostasis; Human subjects; Humans; Inflammation; Inflammation - immunology; Leukocytes; Leukocytes - immunology; Metabolism; Mice; Molecular Structure; Peritonitis; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Stereoisomerism

E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis. Aspirin, in addition to exerting antithrombotic actions, also triggers the biosynthesi...