Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis. Aspirin, in addition to exerting antithrombotic actions, also triggers the biosynthesi...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of clinical investigation Vol. 121; no. 2; pp. 569 - 581
Main Authors Oh, Sungwhan F, Pillai, Padmini S, Recchiuti, Antonio, Yang, Rong, Serhan, Charles N
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.02.2011
Subjects
Online AccessGet full text

Cover

Loading…
Abstract E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis. Aspirin, in addition to exerting antithrombotic actions, also triggers the biosynthesis of these specialized pro-resolving mediators. Here, we used metabolomic profiling to investigate the biosynthesis of E-series resolvins with specific chiral chemistry in serum from human subjects and present evidence for new 18S series resolvins. Aspirin increased endogenous formation of 18S-hydroxyeicosapentaenoate (18S-HEPE) compared with 18R-HEPE, a known resolvin precursor. Human recombinant 5-lipoxygenase used both enantiomers as substrates, and recombinant LTA4 hydrolase (LTA4H) converted chiral 5S(6)-epoxide-containing intermediates to resolvin E1 and 18S-resolvin E1 (RvE1 and 18S-RvE1, respectively). 18S-RvE1 bound to the leukocyte GPCRs ChemR23 and BLT1 with increased affinity and potency compared with the R-epimer, but was more rapidly inactivated than RvE1 by dehydrogenase. Like RvE1, 18S-RvE1 enhanced macrophage phagocytosis of zymosan, E. coli, and apoptotic neutrophils and reduced both neutrophil infiltration and proinflammatory cytokines in murine peritonitis. These results demonstrate two parallel stereospecific pathways in the biosynthesis of E-series resolvins, 18R- and 18S-, which are antiinflammatory, pro-resolving, and non-phlogistic and may contribute to the beneficial actions of aspirin and ω-3 polyunsaturated fatty acids.
AbstractList E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis. Aspirin, in addition to exerting antithrombotic actions, also triggers the biosynthesis of these specialized pro-resolving mediators. Here, we used metabolomic profiling to investigate the biosynthesis of E-series resolvins with specific chiral chemistry in serum from human subjects and present evidence for new 18 S series resolvins. Aspirin increased endogenous formation of 18 S -hydroxyeicosapentaenoate (18 S -HEPE) compared with 18 R -HEPE, a known resolvin precursor. Human recombinant 5-lipoxygenase used both enantiomers as substrates, and recombinant LTA 4 hydrolase (LTA4H) converted chiral 5 S (6)-epoxide–containing intermediates to resolvin E1 and 18 S -resolvin E1 (RvE1 and 18 S -RvE1, respectively). 18 S -RvE1 bound to the leukocyte GPCRs ChemR23 and BLT1 with increased affinity and potency compared with the R-epimer, but was more rapidly inactivated than RvE1 by dehydrogenase. Like RvE1, 18 S -RvE1 enhanced macrophage phagocytosis of zymosan, E. coli , and apoptotic neutrophils and reduced both neutrophil infiltration and proinflammatory cytokines in murine peritonitis. These results demonstrate two parallel stereospecific pathways in the biosynthesis of E-series resolvins, 18 R - and 18 S -, which are antiinflammatory, pro-resolving, and non-phlogistic and may contribute to the beneficial actions of aspirin and ω-3 polyunsaturated fatty acids.
E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis. Aspirin, in addition to exerting antithrombotic actions, also triggers the biosynthesis of these specialized pro-resolving mediators. Here, we used metabolomic profiling to investigate the biosynthesis of E-series resolvins with specific chiral chemistry in serum from human subjects and present evidence for new 18S series resolvins. Aspirin increased endogenous formation of 18S-hydroxyeicosapentaenoate (18S-HEPE) compared with 18R-HEPE, a known resolvin precursor. Human recombinant 5-lipoxygenase used both enantiomers as substrates, and recombinant LTA4 hydrolase (LTA4H) converted chiral 5S(6)-epoxide-containing intermediates to resolvin E1 and 18S-resolvin E1 (RvE1 and 18S-RvE1, respectively). 18S-RvE1 bound to the leukocyte GPCRs ChemR23 and BLT1 with increased affinity and potency compared with the R-epimer, but was more rapidly inactivated than RvE1 by dehydrogenase. Like RvE1, 18S-RvE1 enhanced macrophage phagocytosis of zymosan, E. coli, and apoptotic neutrophils and reduced both neutrophil infiltration and proinflammatory cytokines in murine peritonitis. These results demonstrate two parallel stereospecific pathways in the biosynthesis of E-series resolvins, 18R- and 18S-, which are antiinflammatory, pro-resolving, and non-phlogistic and may contribute to the beneficial actions of aspirin and ω-3 polyunsaturated fatty acids.
Author Oh, Sungwhan F
Pillai, Padmini S
Yang, Rong
Recchiuti, Antonio
Serhan, Charles N
AuthorAffiliation Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
AuthorAffiliation_xml – name: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Author_xml – sequence: 1
  givenname: Sungwhan F
  surname: Oh
  fullname: Oh, Sungwhan F
  organization: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115-5727, USA
– sequence: 2
  givenname: Padmini S
  surname: Pillai
  fullname: Pillai, Padmini S
– sequence: 3
  givenname: Antonio
  surname: Recchiuti
  fullname: Recchiuti, Antonio
– sequence: 4
  givenname: Rong
  surname: Yang
  fullname: Yang, Rong
– sequence: 5
  givenname: Charles N
  surname: Serhan
  fullname: Serhan, Charles N
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21206090$$D View this record in MEDLINE/PubMed
BookMark eNpdkd9rFDEQx4NU7LUK_gUSfNGX1fzczb4I5ajaUqigPodsbtLLuZvUzO7BgX-8e15bap8GZj58ZobvCTlKOQEhrzn7wHkjPm58VEIr_YwsuNamMkKaI7JgTPCqbaQ5JieIG8a4Ulq9IMeCC1azli3In28lVwUw99uYbqjzY8wJqUsriiMUyAg9zM0t0C5m3KVxDRiR5kC5-U7PK4QSAem9AmlMdD0NLtEepl_Z70Y46IapxATzOPRuGNx-z0vyPLge4dVdPSU_P5__WH6trq6_XCzPriqvmRyrxjDoQi2E0N6spPFKBq0b6aTgCsRKhbZlLQRlhAiBG6h5p2Td1tCpumVanpJPB-_t1A2w8pDG4np7W-Lgys5mF-3_kxTX9iZvrWSibriZBe_uBCX_ngBHO0T00PcuQZ7QGtUyzuZNM_n2CbnJU0nzd9Zoo2om1R56f4B8yYgFwsMpnNl9oPZyefEv0Bl98_j0B_A-QfkXhIOfCA
CitedBy_id crossref_primary_10_1371_journal_pone_0024422
crossref_primary_10_1371_journal_pone_0102362
crossref_primary_10_1111_apt_17646
crossref_primary_10_1016_j_jacl_2017_06_011
crossref_primary_10_1016_j_pharmthera_2013_04_006
crossref_primary_10_1152_ajpcell_00024_2014
crossref_primary_10_1161_ATVBAHA_113_301476
crossref_primary_10_1016_j_bcp_2022_115330
crossref_primary_10_1016_j_jhip_2024_04_004
crossref_primary_10_1111_imr_13278
crossref_primary_10_3389_fimmu_2021_660865
crossref_primary_10_1073_pnas_1206641109
crossref_primary_10_1096_fj_201903025RR
crossref_primary_10_1021_acs_orglett_0c00089
crossref_primary_10_1194_jlr_M060392
crossref_primary_10_1016_j_biochi_2020_06_010
crossref_primary_10_1016_j_jnutbio_2012_05_012
crossref_primary_10_1016_j_jpba_2021_114430
crossref_primary_10_1016_j_jnutbio_2013_03_005
crossref_primary_10_7759_cureus_47318
crossref_primary_10_1016_j_freeradbiomed_2012_08_565
crossref_primary_10_3390_ijms23094808
crossref_primary_10_1097_MED_0b013e3283514e00
crossref_primary_10_1186_s40104_020_00513_7
crossref_primary_10_3390_ijms24021637
crossref_primary_10_1042_EBC20200018
crossref_primary_10_1038_srep03113
crossref_primary_10_3390_ijms22052750
crossref_primary_10_1111_nyas_12445
crossref_primary_10_1139_cjpp_2016_0615
crossref_primary_10_1002_cbin_10345
crossref_primary_10_3390_ani11030719
crossref_primary_10_1194_jlr_M045583
crossref_primary_10_1189_jlb_0311145
crossref_primary_10_1097_MOH_0000000000000822
crossref_primary_10_3389_fimmu_2020_623052
crossref_primary_10_1016_j_drudis_2014_06_023
crossref_primary_10_1038_s41569_023_00984_x
crossref_primary_10_1128_IAI_02444_14
crossref_primary_10_1038_s41598_024_61144_w
crossref_primary_10_1016_j_prostaglandins_2012_01_005
crossref_primary_10_1172_JCI97943
crossref_primary_10_1039_D1OB01932E
crossref_primary_10_18632_oncotarget_14210
crossref_primary_10_1155_2019_8107265
crossref_primary_10_1096_fj_13_236224
crossref_primary_10_3390_cancers14061504
crossref_primary_10_5551_jat_33928
crossref_primary_10_1038_s41598_022_15461_7
crossref_primary_10_1002_sctm_19_0078
crossref_primary_10_1007_s00011_015_0852_7
crossref_primary_10_1016_j_jnutbio_2018_02_015
crossref_primary_10_1146_annurev_nutr_071811_150726
crossref_primary_10_3389_fimmu_2021_637983
crossref_primary_10_1021_acsmedchemlett_0c00639
crossref_primary_10_1172_JCI97950
crossref_primary_10_1016_j_bbalip_2021_158936
crossref_primary_10_3389_fphar_2019_00252
crossref_primary_10_3164_jcbn_14_18
crossref_primary_10_1038_s41581_021_00454_y
crossref_primary_10_1002_jpen_2448
crossref_primary_10_1016_j_prostaglandins_2017_01_002
crossref_primary_10_1002_cpt_2165
crossref_primary_10_1016_j_biotechadv_2018_02_014
crossref_primary_10_1089_ars_2021_0156
crossref_primary_10_1096_fj_201600360R
crossref_primary_10_1016_j_jphs_2024_02_010
crossref_primary_10_3390_nu13020508
crossref_primary_10_1080_1744666X_2023_2232554
crossref_primary_10_3389_fphar_2019_00169
crossref_primary_10_1186_1476_511X_12_89
crossref_primary_10_1111_bpa_12812
crossref_primary_10_1016_j_bbalip_2011_06_007
crossref_primary_10_1016_j_ebiom_2016_04_033
crossref_primary_10_1111_joim_12871
crossref_primary_10_1016_j_smim_2022_101597
crossref_primary_10_3390_metabo12040333
crossref_primary_10_3390_cells12010122
crossref_primary_10_1016_j_cbi_2019_04_037
crossref_primary_10_1016_j_tins_2011_08_005
crossref_primary_10_1177_1933719115618282
crossref_primary_10_3390_nu9080858
crossref_primary_10_1016_j_molmed_2015_10_001
crossref_primary_10_1016_j_prostaglandins_2017_06_003
crossref_primary_10_3390_molecules27051677
crossref_primary_10_1189_jlb_3HI0515_189R
crossref_primary_10_3390_md10112535
crossref_primary_10_1016_j_mam_2017_08_002
crossref_primary_10_1016_j_exger_2014_04_005
crossref_primary_10_1089_ars_2017_7332
crossref_primary_10_1038_nri_2015_4
crossref_primary_10_1016_j_bbi_2015_12_013
crossref_primary_10_1111_bph_14151
crossref_primary_10_1016_j_ejphar_2015_03_092
crossref_primary_10_1111_prd_12034
crossref_primary_10_1038_nm_3911
crossref_primary_10_1007_s11883_017_0696_4
crossref_primary_10_1096_fj_201800173R
crossref_primary_10_3389_fphar_2019_01022
crossref_primary_10_1016_j_actbio_2021_01_020
crossref_primary_10_1016_j_ejmech_2017_07_018
crossref_primary_10_1016_j_plefa_2013_02_008
crossref_primary_10_1002_path_4232
crossref_primary_10_3389_fimmu_2022_867261
crossref_primary_10_1017_S0029665113003030
crossref_primary_10_1016_j_mam_2017_03_004
crossref_primary_10_1016_j_mam_2017_03_005
crossref_primary_10_1017_S0007114521001124
crossref_primary_10_3389_fphar_2022_838782
crossref_primary_10_1016_j_plipres_2012_02_003
crossref_primary_10_1016_j_mam_2017_03_001
crossref_primary_10_4049_jimmunol_1103688
crossref_primary_10_1586_eci_11_58
crossref_primary_10_1194_jlr_M039842
crossref_primary_10_1371_journal_pone_0109270
crossref_primary_10_2337_db12_0828
crossref_primary_10_1038_s42003_020_01410_5
crossref_primary_10_3390_pharmaceutics14030520
crossref_primary_10_1096_fj_201901590R
crossref_primary_10_1152_ajpheart_00201_2017
crossref_primary_10_1016_j_biopha_2022_113980
crossref_primary_10_1007_s11883_011_0206_z
crossref_primary_10_1161_CIRCULATIONAHA_117_032801
crossref_primary_10_1039_C7OB02113E
crossref_primary_10_1096_fj_201601222R
crossref_primary_10_3945_ajcn_115_116384
crossref_primary_10_1186_s12974_020_01997_w
crossref_primary_10_1016_j_plefa_2017_06_007
crossref_primary_10_1051_ocl_2015062
crossref_primary_10_1016_j_smim_2018_09_002
crossref_primary_10_12998_wjcc_v4_i7_155
crossref_primary_10_3233_NHA_220184
crossref_primary_10_1111_bph_12451
crossref_primary_10_1111_j_1476_5381_2011_01649_9_x
crossref_primary_10_1002_jms_3595
crossref_primary_10_1161_CIRCRESAHA_116_307308
crossref_primary_10_1007_s12079_021_00630_6
crossref_primary_10_1007_s10555_021_10017_z
crossref_primary_10_1016_j_bcp_2023_115437
crossref_primary_10_1016_j_jaip_2018_12_014
crossref_primary_10_1096_fj_201601095R
crossref_primary_10_3390_ijms23031432
crossref_primary_10_1016_j_tips_2018_01_003
crossref_primary_10_1096_fj_202002471R
crossref_primary_10_1038_s41467_020_16080_4
crossref_primary_10_3390_antiox10060933
crossref_primary_10_1021_cr100396c
crossref_primary_10_1007_s12272_020_01299_y
crossref_primary_10_3390_cells13030255
crossref_primary_10_1373_clinchem_2012_190199
crossref_primary_10_1016_j_neuroscience_2022_11_001
crossref_primary_10_1093_jb_mvs092
crossref_primary_10_1007_s00281_013_0374_8
crossref_primary_10_1016_j_pharmthera_2018_01_004
crossref_primary_10_1002_JLB_3HI1017_405RR
crossref_primary_10_1016_j_jtos_2020_04_011
crossref_primary_10_1016_j_plefa_2016_01_001
crossref_primary_10_1016_j_bcp_2012_08_004
crossref_primary_10_1111_1440_1681_12825
crossref_primary_10_1016_j_immuni_2014_02_009
crossref_primary_10_3390_ijms232314883
crossref_primary_10_3390_ijms19010180
crossref_primary_10_1152_ajplung_00266_2015
crossref_primary_10_3390_metabo14060314
crossref_primary_10_1074_jbc_M112_340612
crossref_primary_10_1038_nature13479
crossref_primary_10_1111_jeu_12263
crossref_primary_10_3390_cells2020330
crossref_primary_10_1016_j_bbalip_2020_158806
crossref_primary_10_1155_2015_690692
crossref_primary_10_1161_ATVBAHA_112_253435
crossref_primary_10_19185_matters_201602000029
crossref_primary_10_1152_physrev_00004_2012
crossref_primary_10_1074_jbc_M116_769125
crossref_primary_10_1161_CIRCRESAHA_121_319822
crossref_primary_10_1016_j_bbalip_2014_08_006
crossref_primary_10_1039_D0OB02218G
crossref_primary_10_1042_BJ20110327
crossref_primary_10_1146_annurev_immunol_020711_074942
crossref_primary_10_1038_s41401_020_00523_1
crossref_primary_10_3390_molecules25020349
crossref_primary_10_3389_fimmu_2020_01249
crossref_primary_10_1096_fj_201802445R
crossref_primary_10_1038_nature11042
crossref_primary_10_1093_jb_mvs151
crossref_primary_10_1101_cshperspect_a041172
crossref_primary_10_3390_ijms18030476
crossref_primary_10_3390_cells12081111
crossref_primary_10_1016_j_smim_2015_03_004
crossref_primary_10_3390_ijms19041227
crossref_primary_10_3389_fimmu_2020_631319
crossref_primary_10_1021_acs_joc_0c02913
crossref_primary_10_1002_mnfr_201900824
crossref_primary_10_1016_j_plefa_2013_09_011
crossref_primary_10_4155_fmc_2022_0206
crossref_primary_10_1007_s10555_018_9743_z
crossref_primary_10_1002_med_21251
crossref_primary_10_4049_jimmunol_1100150
crossref_primary_10_1007_s00784_016_1750_2
crossref_primary_10_1096_fj_11_201442
crossref_primary_10_1089_ars_2020_8143
crossref_primary_10_1002_path_4050
crossref_primary_10_1007_s10753_015_0252_8
crossref_primary_10_1016_j_arr_2024_102352
crossref_primary_10_4049_jimmunol_1300699
crossref_primary_10_3389_fnut_2022_998291
crossref_primary_10_4049_jimmunol_1103652
crossref_primary_10_4049_jimmunol_1600859
crossref_primary_10_3390_ijms222312803
crossref_primary_10_1096_fj_13_227728
crossref_primary_10_4049_jimmunol_1402166
crossref_primary_10_1016_j_coph_2013_05_012
crossref_primary_10_1155_2013_191823
crossref_primary_10_1161_JAHA_115_002034
crossref_primary_10_1194_jlr_M038505
Cites_doi 10.1172/JCI1578
10.1038/nrd1034
10.1084/jem.20040566
10.1074/jbc.R400027200
10.1172/JCI9523
10.1073/pnas.84.19.6677
10.1073/pnas.81.3.689
10.1073/pnas.061607398
10.1073/pnas.0907342107
10.1016/j.plefa.2008.09.016
10.1016/S0021-9258(19)36629-3
10.1073/pnas.92.21.9475
10.1021/bi00076a002
10.4049/jimmunol.174.7.4345
10.1124/jpet.300.2.385
10.1021/bi992551b
10.1073/pnas.0405445101
10.1074/jbc.M609212200
10.1016/S1056-8719(00)00125-8
10.1038/sj.bjp.0707489
10.1038/scientificamerican0191-84
10.1016/S0149-2918(03)80116-9
10.1073/pnas.89.16.7384
10.1038/nature08541
10.1089/adt.2006.052
10.4049/jimmunol.180.5.3512
10.1021/bi00011a007
10.2353/ajpath.2009.080671
10.1016/j.chembiol.2006.11.002
10.1084/jem.20020760
10.1038/nrcardio.2009.188
10.3181/0711-MR-311
10.1073/pnas.96.14.8247
10.1038/2211251b0
10.1016/j.chembiol.2006.09.011
10.1016/j.plefa.2009.01.008
10.1021/bi00044a041
10.1172/JCI200318012
10.1084/jem.192.8.1197
10.1038/nri2294
10.1146/annurev.immunol.25.022106.141647
10.1016/j.tips.2007.02.003
10.1073/pnas.81.17.5335
10.4049/jimmunol.0900477
10.1172/JCI118074
10.1016/S0140-6736(07)60527-3
10.1016/S0140-6736(99)07072-5
10.1038/84117
10.4049/jimmunol.178.6.3912
10.1038/nature05877
10.1084/jem.20042031
10.4049/jimmunol.181.12.8677
10.1038/89759
10.1124/mi.9.1.8
ContentType Journal Article
Copyright Copyright American Society for Clinical Investigation Feb 2011
Copyright © 2011, American Society for Clinical Investigation
Copyright_xml – notice: Copyright American Society for Clinical Investigation Feb 2011
– notice: Copyright © 2011, American Society for Clinical Investigation
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7RV
7X7
7XB
88A
88E
8AO
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BEC
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
KB0
LK8
M0S
M1P
M7P
NAPCQ
PQEST
PQQKQ
PQUKI
PRINS
S0X
7X8
5PM
DOI 10.1172/jci42545
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
eLibrary
ProQuest Databases
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Nursing & Allied Health Premium
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
SIRS Editorial
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
ProQuest Central Essentials
SIRS Editorial
elibrary
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
ProQuest Central Student
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1558-8238
EndPage 581
ExternalDocumentID 2301806641
10_1172_JCI42545
21206090
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: GM38765
– fundername: NIDDK NIH HHS
  grantid: DK074448
– fundername: NIDDK NIH HHS
  grantid: R01 DK074448
– fundername: NIGMS NIH HHS
  grantid: R01 GM038765
– fundername: NIGMS NIH HHS
  grantid: R37 GM038765
GroupedDBID ---
-~X
.55
.GJ
.XZ
08G
08P
29K
2WC
354
36B
3O-
3V.
53G
5GY
5RE
5RS
7RV
7X7
88A
88E
8AO
8F7
8FE
8FH
8FI
8FJ
8R4
8R5
AAKAS
AAWTL
AAYOK
ABOCM
ABPMR
ABUWG
ACGFO
ACIHN
ACNCT
ACPRK
ADBBV
ADZCM
AEAQA
AENEX
AFCHL
AFFNX
AFKRA
AHMBA
AI.
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ASPBG
AVWKF
AZFZN
BAWUL
BBNVY
BCR
BCU
BEC
BENPR
BHPHI
BKEYQ
BLC
BPHCQ
BVXVI
CCPQU
CGR
CS3
CUY
CVF
D-I
DIK
DU5
E3Z
EBD
EBS
ECM
EIF
EJD
EMB
EMOBN
EX3
F5P
FEDTE
FRP
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HVGLF
HYE
H~9
IAO
IEA
IHR
IHW
INH
INR
IOF
IOV
IPO
ISR
ITC
J5H
KQ8
L7B
LK8
M0L
M1P
M5~
M7P
MVM
N4W
NAPCQ
NPM
OBH
OCB
ODZKP
OFXIZ
OGEVE
OHH
OHT
OK1
OVD
OVIDX
P2P
P6G
PQQKQ
PROAC
PSQYO
Q2X
RPM
S0X
SJFOW
SV3
TEORI
TR2
TVE
UHU
UKHRP
VH1
VVN
W2D
WH7
WOQ
WOW
X7M
XSB
YFH
YHG
YKV
YOC
ZGI
ZXP
ZY1
~H1
AAYXX
CITATION
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c503t-780ebf62225c8d38c43f5573a3214e2d4f9909ef4822ff18e61b43696eb469053
IEDL.DBID RPM
ISSN 0021-9738
IngestDate Tue Sep 17 21:25:23 EDT 2024
Fri Oct 25 22:59:36 EDT 2024
Thu Oct 10 22:41:38 EDT 2024
Thu Sep 26 17:37:22 EDT 2024
Sat Sep 28 07:57:04 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c503t-780ebf62225c8d38c43f5573a3214e2d4f9909ef4822ff18e61b43696eb469053
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://www.jci.org/articles/view/42545/files/pdf
PMID 21206090
PQID 858460343
PQPubID 42166
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026718
proquest_miscellaneous_849010053
proquest_journals_858460343
crossref_primary_10_1172_JCI42545
pubmed_primary_21206090
PublicationCentury 2000
PublicationDate 2011-02-01
PublicationDateYYYYMMDD 2011-02-01
PublicationDate_xml – month: 02
  year: 2011
  text: 2011-02-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Ann Arbor
PublicationTitle The Journal of clinical investigation
PublicationTitleAlternate J Clin Invest
PublicationYear 2011
Publisher American Society for Clinical Investigation
Publisher_xml – name: American Society for Clinical Investigation
References 15238606 - J Exp Med. 2004 Jul 5;200(1):69-78
15753205 - J Exp Med. 2005 Mar 7;201(5):713-22
17114001 - Chem Biol. 2006 Nov;13(11):1193-202
17965751 - Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15
19865173 - Nature. 2009 Oct 29;461(7268):1287-91
19597002 - J Immunol. 2009 Aug 1;183(3):2089-96
17090225 - Annu Rev Immunol. 2007;25:101-37
7893649 - Biochemistry. 1995 Mar 21;34(11):3536-43
19859067 - Nat Rev Cardiol. 2009 Dec;6(12):753-8
17113992 - Chem Biol. 2006 Nov;13(11):1121-2
11192938 - J Physiol Pharmacol. 2000 Dec;51(4 Pt 1):643-54
11325577 - J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):333-40
7568157 - Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9475-9
18408140 - Exp Biol Med (Maywood). 2008 Jun;233(6):674-88
15778399 - J Immunol. 2005 Apr 1;174(7):4345-55
15471991 - Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15178-83
12391014 - J Exp Med. 2002 Oct 21;196(8):1025-37
7578068 - Biochemistry. 1995 Nov 7;34(44):14609-15
17339491 - J Immunol. 2007 Mar 15;178(6):3912-7
17331592 - Trends Pharmacol Sci. 2007 Apr;28(4):162-5
17568749 - Nature. 2007 Jun 14;447(7146):869-74
17355206 - Assay Drug Dev Technol. 2007 Feb;5(1):137-44
11034610 - J Exp Med. 2000 Oct 16;192(8):1197-204
5813101 - Nature. 1969 Mar 29;221(5187):1251-3
17398308 - Lancet. 2007 Mar 31;369(9567):1090-8
18437155 - Nat Rev Immunol. 2008 May;8(5):349-61
12612644 - Nat Rev Drug Discov. 2003 Mar;2(3):179-91
18951005 - Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8
10811855 - J Clin Invest. 2000 May;105(10):1473-82
1400457 - J Biol Chem. 1992 Oct 25;267(30):21438-45
9808710 - J Pharmacol Exp Ther. 1998 Nov;287(2):779-90
20080636 - Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5
9466977 - J Clin Invest. 1998 Feb 15;101(4):819-26
18292578 - J Immunol. 2008 Mar 1;180(5):3512-9
6089195 - Proc Natl Acad Sci U S A. 1984 Sep;81(17):5335-9
2821541 - Proc Natl Acad Sci U S A. 1987 Oct;84(19):6677-81
10465168 - Lancet. 1999 Aug 7;354(9177):447-55
1380156 - Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7384-8
10769133 - Biochemistry. 2000 Apr 25;39(16):4761-8
6322165 - Proc Natl Acad Sci U S A. 1984 Feb;81(3):689-93
11429545 - Nat Immunol. 2001 Jul;2(7):612-9
12852710 - Clin Ther. 2003 Mar;25(3):948-71
17244615 - J Biol Chem. 2007 Mar 30;282(13):9323-34
15339917 - J Biol Chem. 2004 Dec 3;279(49):50639-42
12975479 - J Clin Invest. 2003 Sep;112(6):945-55
7542286 - J Clin Invest. 1995 Jul;96(1):60-8
8518275 - Biochemistry. 1993 Jun 29;32(25):6313-9
11248083 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3358-63
19050288 - J Immunol. 2008 Dec 15;181(12):8677-87
19264468 - Prostaglandins Leukot Essent Fatty Acids. 2009 Apr;80(4):177-83
10393980 - Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8247-52
11175901 - Nat Struct Biol. 2001 Feb;8(2):131-5
19299662 - Mol Interv. 2009 Feb;9(1):31-9
11805195 - J Pharmacol Exp Ther. 2002 Feb;300(2):385-92
1899486 - Sci Am. 1991 Jan;264(1):84-90
19095947 - Am J Pathol. 2009 Jan;174(1):115-22
B20
B21
B22
Holtzman (B8) 1992; 267
B24
Bannenberg (B52) 2005; 174
B26
B27
B28
B29
Hong (B56) 2008; 180
Simopoulos (B15) 2008; 233
Serhan (B25) 2000; 51
Haeggstrom (B49) 2004; 279
B30
B31
Chiang (B34) 1998; 287
B33
B35
B38
B1
B3
B5
B6
B7
Bell-Parikh (B4) 2003; 112
Serhan (B17) 2008; 8
B9
Calder (B16) 2008; 79
B40
B41
B42
B43
B44
B45
B46
Ramwell (B37) 1969; 221
B47
B48
Weissmann (B36) 1991; 264
Kasuga (B39) 2008; 181
Serhan (B2) 2008; 153
B50
B51
B53
B10
B54
B11
B55
B12
B13
B57
B14
B18
B19
Yokoyama (B32) 2007; 369
Arita (B23) 2007; 178
References_xml – ident: B12
  doi: 10.1172/JCI1578
– ident: B41
  doi: 10.1038/nrd1034
– ident: B35
  doi: 10.1084/jem.20040566
– volume: 279
  start-page: 50639
  year: 2004
  ident: B49
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.R400027200
  contributor:
    fullname: Haeggstrom
– ident: B42
  doi: 10.1172/JCI9523
– ident: B48
  doi: 10.1073/pnas.84.19.6677
– ident: B21
  doi: 10.1073/pnas.81.3.689
– ident: B43
  doi: 10.1073/pnas.061607398
– ident: B55
  doi: 10.1073/pnas.0907342107
– volume: 79
  start-page: 101
  year: 2008
  ident: B16
  publication-title: Prostaglandins Leukot Essent Fatty Acids.
  doi: 10.1016/j.plefa.2008.09.016
  contributor:
    fullname: Calder
– volume: 267
  start-page: 21438
  year: 1992
  ident: B8
  publication-title: J Biol Chem.
  doi: 10.1016/S0021-9258(19)36629-3
  contributor:
    fullname: Holtzman
– ident: B9
  doi: 10.1073/pnas.92.21.9475
– ident: B50
  doi: 10.1021/bi00076a002
– volume: 174
  start-page: 4345
  year: 2005
  ident: B52
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.174.7.4345
  contributor:
    fullname: Bannenberg
– ident: B14
  doi: 10.1124/jpet.300.2.385
– ident: B13
  doi: 10.1021/bi992551b
– ident: B33
  doi: 10.1073/pnas.0405445101
– ident: B51
  doi: 10.1074/jbc.M609212200
– ident: B44
  doi: 10.1016/S1056-8719(00)00125-8
– volume: 153
  start-page: S200
  year: 2008
  ident: B2
  publication-title: Br J Pharmacol.
  doi: 10.1038/sj.bjp.0707489
  contributor:
    fullname: Serhan
– volume: 264
  start-page: 84
  year: 1991
  ident: B36
  publication-title: Sci Am.
  doi: 10.1038/scientificamerican0191-84
  contributor:
    fullname: Weissmann
– ident: B38
  doi: 10.1016/S0149-2918(03)80116-9
– ident: B40
  doi: 10.1073/pnas.89.16.7384
– ident: B53
  doi: 10.1038/nature08541
– ident: B54
  doi: 10.1089/adt.2006.052
– volume: 180
  start-page: 3512
  year: 2008
  ident: B56
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.180.5.3512
  contributor:
    fullname: Hong
– ident: B22
  doi: 10.1021/bi00011a007
– ident: B27
  doi: 10.2353/ajpath.2009.080671
– ident: B46
  doi: 10.1016/j.chembiol.2006.11.002
– ident: B18
  doi: 10.1084/jem.20020760
– volume: 51
  start-page: 643
  year: 2000
  ident: B25
  publication-title: J Physiol Pharmacol.
  contributor:
    fullname: Serhan
– ident: B30
  doi: 10.1038/nrcardio.2009.188
– volume: 233
  start-page: 674
  year: 2008
  ident: B15
  publication-title: Exp Biol Med (Maywood).
  doi: 10.3181/0711-MR-311
  contributor:
    fullname: Simopoulos
– ident: B1
– ident: B57
  doi: 10.1073/pnas.96.14.8247
– volume: 221
  start-page: 1251
  year: 1969
  ident: B37
  publication-title: Nature.
  doi: 10.1038/2211251b0
  contributor:
    fullname: Ramwell
– ident: B20
  doi: 10.1016/j.chembiol.2006.09.011
– ident: B28
  doi: 10.1016/j.plefa.2009.01.008
– ident: B11
  doi: 10.1021/bi00044a041
– volume: 112
  start-page: 945
  year: 2003
  ident: B4
  publication-title: J Clin Invest.
  doi: 10.1172/JCI200318012
  contributor:
    fullname: Bell-Parikh
– ident: B45
  doi: 10.1084/jem.192.8.1197
– volume: 8
  start-page: 249
  year: 2008
  ident: B17
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2294
  contributor:
    fullname: Serhan
– ident: B7
  doi: 10.1146/annurev.immunol.25.022106.141647
– ident: B5
  doi: 10.1016/j.tips.2007.02.003
– ident: B10
  doi: 10.1073/pnas.81.17.5335
– ident: B29
  doi: 10.4049/jimmunol.0900477
– ident: B3
  doi: 10.1172/JCI118074
– volume: 369
  start-page: 1090
  year: 2007
  ident: B32
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(07)60527-3
  contributor:
    fullname: Yokoyama
– volume: 287
  start-page: 779
  year: 1998
  ident: B34
  publication-title: J Pharmacol Exp Ther.
  contributor:
    fullname: Chiang
– ident: B31
  doi: 10.1016/S0140-6736(99)07072-5
– ident: B47
  doi: 10.1038/84117
– volume: 178
  start-page: 3912
  year: 2007
  ident: B23
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.178.6.3912
  contributor:
    fullname: Arita
– ident: B24
  doi: 10.1038/nature05877
– ident: B19
  doi: 10.1084/jem.20042031
– volume: 181
  start-page: 8677
  year: 2008
  ident: B39
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.181.12.8677
  contributor:
    fullname: Kasuga
– ident: B26
  doi: 10.1038/89759
– ident: B6
  doi: 10.1124/mi.9.1.8
SSID ssj0014454
Score 2.5234485
Snippet E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 569
SubjectTerms Animals
Anti-Inflammatory Agents, Non-Steroidal - immunology
Arachidonate 5-Lipoxygenase - genetics
Arachidonate 5-Lipoxygenase - metabolism
Aspirin
Aspirin - immunology
Biomedical research
Biosynthesis
Cyclooxygenase 2 - metabolism
E coli
Eicosapentaenoic Acid - analogs & derivatives
Eicosapentaenoic Acid - biosynthesis
Eicosapentaenoic Acid - blood
Enzymes
Fatty acids
Fatty Acids, Omega-3 - immunology
Fatty Acids, Omega-3 - metabolism
Fish Oils - administration & dosage
Fish Oils - chemistry
Homeostasis
Human subjects
Humans
Inflammation
Inflammation - immunology
Leukocytes
Leukocytes - immunology
Metabolism
Mice
Molecular Structure
Peritonitis
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Stereoisomerism
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Na90wDDdbB2OXse-lXYcHu5o6sZ34nUopLV2hY7AV3i3kQ2bZ2rir3zsU9sdXcvxCu8LONo6xFP8kWdKPsc-IOUY6A0Jap4VW6KdYyLVoAK0HcJ3pY1HY2dfy5FyfLs0y5eaElFa5uRPjRd37jmLke5aQUiqt9q_-CCKNosfVxKDxmD3JC0RyVOdqOftb6CqY1IQ5F4tK2dR7FiF771c3oLJSDdNdNHpgYv6bKXkHeo5fsOfJZuQHk5BfskcwvmJPz9Kr-Gv299u1F-g2-wuKDvCpVCHwZuw5tUEAHyLZDd5rvB18uBnR6AtD4N7x3H7nR4LUEALfLBH4MPJI3scvYP3bdzdoj8blLik2DzjsUJGmosc37Pz46MfhiUisCqIzUq1EZSW0riQ_r7O9sp1WzphKNURZBEWvHQLUApxGMTqXWyjzVhPrH7TkShv1lm2NfoT3jPe6am1pFTh6F857K11bFFVTWt0ujFMZ-7Q53fpqap5RR6ejKurTwy9RAhnb2Rx7nX6fUM_CzhifR1Hv6TGjGcGvcYqmxBLcTsbeTTKaP4FoLEu5kBmr7klvnkAtte-PjMPP2FpbESFXbrf_u6kd9myKLFNSywe2tbpewy6aJqv2Y1TAW3BJ5WY
  priority: 102
  providerName: ProQuest
Title Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
URI https://www.ncbi.nlm.nih.gov/pubmed/21206090
https://www.proquest.com/docview/858460343
https://search.proquest.com/docview/849010053
https://pubmed.ncbi.nlm.nih.gov/PMC3026718
Volume 121
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFH_ahoS4IL4pg8pIXL0msZ24RyidtqFOFTCptyhOnrWI1pmW9jCJP55nJ6k2uHGM7DiW3y9-3-8BfCKeoyKrkEfaSi4F6SkaY8kLJOkBbamqkBS2uEzPruTFSq0OQA25MCFovzT1iVtvTlx9HWIrbzblZIgTmywXM-HbJsV6cgiHxH4HFb13HUip-tLLMZ9mQvcVZ4lRTy5m5wRRqUIF4CRKI38T32dH_8iYf4dK3uM9p8_gaS80ss_d5p7DAboX8HjRu8Vfwu_lbcNJb27W3jzAulyFlhWuYr4OAjZt6HZDFxszddPeOZL62rpljWWx_sHm3OMQWzYs0bLasdC9j61x96sp70ggDcttvHEeadgSkrqsx1dwdTr_OTvjfVsFXqpIbHmmIzQ29YpeqSuhSymsUpkofM8iTCppiUNN0Uqio7WxxjQ20rf9Q-N1aSVew5FrHL4FVsnM6FQLtN4xHFc6siZJsiLV0kyVFSP4OJxuftNVz8iD1pEl-UCMERwPx573_0-bay8XRULSCmw_SsD33ozCYbOjKdJHltB2RvCmo9H-EwNxR5A9oN5-gq-p_XCEoBZqa_fQevffbx7Dk87s7CNe3sPR9naHH0hu2ZoxoXWVjeHRl_nl8js9fT3_Ng7Y_QP8X_HM
link.rule.ids 230,314,727,780,784,885,12056,21388,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB61i9RyqfompQ9X6tXCWduJ94RatGih7Aq1IHGL8rBFCsSU7B6Q-uOZSbwRtFLPYzmWZ-J5zwfwBXWOFk5bLoxTXEn0U4yNFc8tWg_WlbrqmsLmi2R2qg7P9FmozWlDWeX6Tewe6sqXFCPfMaQphVRy9_o3J9AoSq4GBI3HsEGD0_UINr5NF8c_hjSCUjqMYY75JJUmTJ9Fpb3zq6xRXKmL6b4--sfI_LtW8p7y2X8Oz4LVyL72bH4Bj2zzEp7MQ178Ffw5vvEcHWd_SfEB1jcrtCxvKkaDEKxvO7gbfNlYUfv2tkGzr61b5h2LzU825SSItmXrLVpWN6yD72OXdnXhy1u0SLvtrig6b5HsUJT6tsfXcLo_Pdmb8YCrwEst5JKnRtjCJeTplaaSplTSaZ3KnECL7LhSDlXUxDqFjHQuNjaJC0W4f7YgZ1rLNzBqfGO3gFUqLUxipHWUGY4rI1wxHqd5YlQx0U5G8Hl9u9l1Pz4j69yOdJwd7h10HIhge33tWfiB2mxgdwRsoKLkUzojb6xf4RJFpSV4nAje9jwaPoH6WCRiIiJIH3BvWEBDtR9Smvq8G64tCZIrNu_-e6hP8HR2Mj_Kjg4W37dhs48zU4nLexgtb1b2Axoqy-JjEMc7SVfpvA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVqq4VLwJ5WEkrtY6sZ14TwjKrtpCVyugUm9RHrYItHFpdg-V-PHMJN6oBYmzrcTyjP3NeB4fwFvEHC2ctlwYp7iS6KcYGyteWLQerKt03ReFnSzTw1N1fKbPQkuhLqRVbu_E_qKufUVv5FNDSCmkklMXsiJWHxfvLn9xIpCiQGtg07gLOwiKIpnAzof5cvVlDCkopUNL5pjPMmlCJ1oE8OmPqkHVpYqmm9j0j8H5d97kDSBa3Ie9YEGy94PIH8Ad2z6E3ZMQI38Ev1dXnqMT7c_prYANhQsdK9qaUVME67ue-gZvOVY2vrtu0QTsmo55x2Lzlc05KaXt2PYTHWta1lP5sXO7-emra7RO-89d0Eu9xWGHajWUQD6G08X828EhDxwLvNJCrnlmhC1dSl5fZWppKiWd1pksiMDIJrVyCFcz6xQK1bnY2DQuFXEA2pIcay2fwKT1rX0GrFZZaVIjraMocVwb4cokyYrUqHKmnYzgzXZ388uhlUbeuyBZkh8fHPUSiGB_u-15OExdPoo-AjaO4img0EbRWr_BKYrSTHA5ETwdZDT-ArFZpGImIshuSW-cQA22b4-0zfe-0bYkeq7YPP_vol7DLmpi_vlo-Wkf7g1PzpTt8gIm66uNfYk2y7p8FbTxD_J-7ek
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pro-resolving+actions+and+stereoselective+biosynthesis+of+18S+E-series+resolvins+in+human+leukocytes+and+murine+inflammation&rft.jtitle=The+Journal+of+clinical+investigation&rft.au=Oh%2C+Sungwhan+F.&rft.au=Pillai%2C+Padmini+S.&rft.au=Recchiuti%2C+Antonio&rft.au=Yang%2C+Rong&rft.date=2011-02-01&rft.pub=American+Society+for+Clinical+Investigation&rft.issn=0021-9738&rft.eissn=1558-8238&rft.volume=121&rft.issue=2&rft.spage=569&rft.epage=581&rft_id=info:doi/10.1172%2FJCI42545&rft_id=info%3Apmid%2F21206090&rft.externalDBID=PMC3026718
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9738&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9738&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9738&client=summon