Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization

• Published in: Clinical & experimental metastasis Vol. 29; no. 5; pp. 397 - 408
• Main Authors: Bainer, Russell O., Veneris, Jennifer Taylor, Yamada, S. Diane, Montag, Anthony, Lingen, Mark W., Gilad, Yoav, Rinker-Schaeffer, Carrie W.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2012; Springer Nature B.V
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cancer Research; Cell adhesion; Colonization; Cytokinesis; Cytoskeleton; DNA microarrays; Expression vectors; Female; Gene expression; Gene Expression Profiling; Hematology; Humans; Immunoenzyme Techniques; MAP kinase; MAP Kinase Kinase 4 - genetics; MAP Kinase Kinase 4 - metabolism; Metastases; Mice; Oligonucleotide Array Sequence Analysis; Omentum - metabolism; Omentum - pathology; Oncology; Ovarian cancer; Ovarian Neoplasms - enzymology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - secondary; Real-Time Polymerase Chain Reaction; Research Paper; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Surgical Oncology; Time Factors; Transcription; Tumor Cells, Cultured; Tumor Stem Cell Assay; Transcriptional profiling; Omentum; Metastasis suppressor; Microarray timecourse; MAP kinase kinase 4; Ovarian cancer

Although metastasis is the most lethal attribute of cancer, critical gaps in our knowledge of how cancer cells effectively colonize distant sites remain. For example, little is known about the cellular and molecular events that occur during the timecourse of metastatic colonization. To address this...