Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death

• Published in: The Journal of Infectious Diseases Vol. 228; no. Supplement_7; pp. S508 - S513
• Main Authors: Makoto, Kuroda, Peter J, Halfmann, Yoshihiro, Kawaoka
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press (OUP) 15.11.2023; Oxford University Press
• Subjects: Apoptosis; Cell Death; Cell membranes; Cell viability; Ebola virus; Ebolavirus; Ebolavirus - physiology; Gene expression; Hemorrhagic Fever, Ebola; Humans; Permissive cells; Phosphatidylserine; RNA, Messenger; RNA, Messenger - metabolism; Supplement; Viral Proteins; Viral Proteins - metabolism; VP40 protein; HCAR2; Ebola virus; cell death

Abstract Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in...