Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death
Abstract Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in...
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| Published in | The Journal of Infectious Diseases Vol. 228; no. Supplement_7; pp. S508 - S513 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press (OUP)
15.11.2023
Oxford University Press |
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| Abstract | Abstract
Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2-specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death. |
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| AbstractList | Abstract
Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2-specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death. Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2-specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death. Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2-specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death.Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2-specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death. Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms. Hydroxycarboxylic acid receptor 2 (HCAR2) has been reported to be involved in apoptotic cell death. We previously reported an increase in the expression of HCAR2 -specific mRNA in EBOV-infected individuals with fatal outcomes. Here, we report that infection with an EBOV lacking the VP30 gene (EBOVΔVP30) results in the upregulation of HCAR2 mRNA expression in human hepatocyte Huh7.0 cells stably expressing VP30. Transient overexpression of HCAR2 reduced the viability of Huh7.0 cells and human embryonic kidney cells. Phosphatidylserine externalization and cell membrane permeabilization by HCAR2 overexpression was also observed. Interestingly, coexpression of HCAR2 with EBOV VP40 further reduced cell viability in transfected cells compared to HCAR2 coexpression with other viral proteins. Our data suggest that HCAR2 may contribute to EBOV-induced cell death. |
| Author | Yoshihiro, Kawaoka Peter J, Halfmann Makoto, Kuroda |
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| Cites_doi | 10.1038/cdd.2017.65 10.1186/s40164-023-00376-4 10.1158/0008-5472.CAN-08-4466 10.1073/pnas.0708057105 10.1016/j.jmb.2021.167249 10.1038/nrd3777 10.1016/j.chom.2017.10.011 10.3390/pathogens11121400 10.1007/s13238-020-00764-0 10.1038/sj.cdd.4402238 10.1128/JVI.01857-05 10.1371/journal.ppat.1008068 10.1158/0008-5472.CAN-13-1451 10.1016/j.virol.2007.02.017 10.1073/pnas.1120453109 10.3389/fcimb.2019.00480 10.1186/s12964-019-0437-0 10.1086/514293 10.1016/S0002-9440(10)63591-2 10.1371/journal.ppat.1006397 10.1038/nature24490 10.1002/1521-4141(200112)31:12<3714::AID-IMMU3714>3.0.CO;2-1 10.1016/S0165-2478(01)00327-3 10.1371/journal.pntd.0000837 10.1128/JVI.02183-06 10.1038/labinvest.3780021 10.1111/imr.12534 10.1093/infdis/jiy433 10.1158/2326-6066.CIR-14-0164 10.3389/fmicb.2016.01765 10.1002/path.1711250303 |
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| Copyright | The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023 The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
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| Keywords | HCAR2 Ebola virus cell death |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Potential conflicts of interest. Y.K. has received unrelated funding support from FUJIFILM Toyama Chemical Co. LTD, Shionogi & Co. LTD, Daiichi Sankyo Pharmaceutical, Otsuka Pharmaceutical, KM Biologics, Kyoritsu Seiyaku, Fuji Rebio, Tauns Laboratories, Inc., and FluGen. |
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| References | Kostylina (2023111521061578800_jiad344-B11) 2008; 15 Ma (2023111521061578800_jiad344-B7) 2019; 9 Baskerville (2023111521061578800_jiad344-B30) 1978; 125 Bharat (2023111521061578800_jiad344-B21) 2012; 109 Hensley (2023111521061578800_jiad344-B1) 2002; 80 Blad (2023111521061578800_jiad344-B8) 2012; 11 Shlomovitz (2023111521061578800_jiad344-B17) 2019; 17 Ryabchikova (2023111521061578800_jiad344-B29) 1999; 179 Noda (2023111521061578800_jiad344-B19) 2007; 81 Johnson (2023111521061578800_jiad344-B20) 2006; 80 Wu (2023111521061578800_jiad344-B18) 2022; 13 Eisfeld (2023111521061578800_jiad344-B6) 2017; 22 Geisbert (2023111521061578800_jiad344-B27) 2003; 163 Gupta (2023111521061578800_jiad344-B2) 2007; 364 Iampietro (2023111521061578800_jiad344-B4) 2017; 13 Bardhan (2023111521061578800_jiad344-B10) 2015; 3 Younan (2023111521061578800_jiad344-B3) 2019; 15 Halfmann (2023111521061578800_jiad344-B26) 2018; 218 Schaub (2023111521061578800_jiad344-B9) 2001; 31 Man (2023111521061578800_jiad344-B25) 2017; 277 Wan (2023111521061578800_jiad344-B22) 2017; 551 Geisbert (2023111521061578800_jiad344-B31) 2000; 80 Lu (2023111521061578800_jiad344-B16) 2022; 11 Thangaraju (2023111521061578800_jiad344-B23) 2009; 69 Nguyen (2023111521061578800_jiad344-B15) 2022; 434 Pleet (2023111521061578800_jiad344-B5) 2016; 7 Guo (2023111521061578800_jiad344-B13) 2023; 12 Halfmann (2023111521061578800_jiad344-B14) 2008; 105 Elangovan (2023111521061578800_jiad344-B12) 2014; 74 Wauquier (2023111521061578800_jiad344-B28) 2010; 4 Grootjans (2023111521061578800_jiad344-B24) 2017; 24 |
| References_xml | – volume: 24 start-page: 1184 year: 2017 ident: 2023111521061578800_jiad344-B24 article-title: Initiation and execution mechanisms of necroptosis: an overview publication-title: Cell Death Differ doi: 10.1038/cdd.2017.65 – volume: 12 start-page: 15 year: 2023 ident: 2023111521061578800_jiad344-B13 article-title: GPR109A Controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis publication-title: Exp Hematol Oncol doi: 10.1186/s40164-023-00376-4 – volume: 69 start-page: 2826 year: 2009 ident: 2023111521061578800_jiad344-B23 article-title: GPR109A Is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4466 – volume: 105 start-page: 1129 year: 2008 ident: 2023111521061578800_jiad344-B14 article-title: Generation of biologically contained Ebola viruses publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0708057105 – volume: 434 start-page: 167249 year: 2022 ident: 2023111521061578800_jiad344-B15 article-title: PANoptosis in viral infection: the missing puzzle piece in the cell death field publication-title: J Mol Biol doi: 10.1016/j.jmb.2021.167249 – volume: 11 start-page: 603 year: 2012 ident: 2023111521061578800_jiad344-B8 article-title: G protein-coupled receptors for energy metabolites as new therapeutic targets publication-title: Nat Rev Drug Discov doi: 10.1038/nrd3777 – volume: 22 start-page: 817 year: 2017 ident: 2023111521061578800_jiad344-B6 article-title: Multi-platform ‘omics analysis of human Ebola virus disease pathogenesis publication-title: Cell Host Microbe doi: 10.1016/j.chom.2017.10.011 – volume: 11 start-page: 1400 year: 2022 ident: 2023111521061578800_jiad344-B16 article-title: Filoviruses: innate immunity, inflammatory cell death, and cytokines publication-title: Pathogens doi: 10.3390/pathogens11121400 – volume: 13 start-page: 120 year: 2022 ident: 2023111521061578800_jiad344-B18 article-title: The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding publication-title: Protein Cell doi: 10.1007/s13238-020-00764-0 – volume: 15 start-page: 134 year: 2008 ident: 2023111521061578800_jiad344-B11 article-title: Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A) publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4402238 – volume: 80 start-page: 5135 year: 2006 ident: 2023111521061578800_jiad344-B20 article-title: Ebola virus VP35-VP40 interaction is sufficient for packaging 3E-5E minigenome RNA into virus-like particles publication-title: J Virol doi: 10.1128/JVI.01857-05 – volume: 15 start-page: e1008068 year: 2019 ident: 2023111521061578800_jiad344-B3 article-title: Ebola virus–mediated T-lymphocyte depletion is the result of an abortive infection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1008068 – volume: 74 start-page: 1166 year: 2014 ident: 2023111521061578800_jiad344-B12 article-title: The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-1451 – volume: 364 start-page: 45 year: 2007 ident: 2023111521061578800_jiad344-B2 article-title: Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro publication-title: Virology doi: 10.1016/j.virol.2007.02.017 – volume: 109 start-page: 4275 year: 2012 ident: 2023111521061578800_jiad344-B21 article-title: Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1120453109 – volume: 9 start-page: 480 year: 2019 ident: 2023111521061578800_jiad344-B7 article-title: Hydroxycarboxylic acid receptor 2 is a Zika virus restriction factor that can be induced by Zika virus infection through the IRE1-XBP1 pathway publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2019.00480 – volume: 17 start-page: 139 year: 2019 ident: 2023111521061578800_jiad344-B17 article-title: Flipping the dogma—phosphatidylserine in non-apoptotic cell death publication-title: Cell Commun Signal doi: 10.1186/s12964-019-0437-0 – volume: 179 start-page: S199 year: 1999 ident: 2023111521061578800_jiad344-B29 article-title: An analysis of features of pathogenesis in two animal models of Ebola virus infection publication-title: J Infect Dis doi: 10.1086/514293 – volume: 163 start-page: 2347 year: 2003 ident: 2023111521061578800_jiad344-B27 article-title: Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)63591-2 – volume: 13 start-page: e1006397 year: 2017 ident: 2023111521061578800_jiad344-B4 article-title: Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1006397 – volume: 551 start-page: 394 year: 2017 ident: 2023111521061578800_jiad344-B22 article-title: Structure and assembly of the Ebola virus nucleocapsid publication-title: Nature doi: 10.1038/nature24490 – volume: 31 start-page: 3714 year: 2001 ident: 2023111521061578800_jiad344-B9 article-title: PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily publication-title: Eur J Immunol doi: 10.1002/1521-4141(200112)31:12<3714::AID-IMMU3714>3.0.CO;2-1 – volume: 80 start-page: 169 year: 2002 ident: 2023111521061578800_jiad344-B1 article-title: Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily publication-title: Immunol Lett doi: 10.1016/S0165-2478(01)00327-3 – volume: 4 start-page: e837 year: 2010 ident: 2023111521061578800_jiad344-B28 article-title: Human fatal Zaire Ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0000837 – volume: 81 start-page: 3554 year: 2007 ident: 2023111521061578800_jiad344-B19 article-title: Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus publication-title: J Virol doi: 10.1128/JVI.02183-06 – volume: 80 start-page: 171 year: 2000 ident: 2023111521061578800_jiad344-B31 article-title: Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses publication-title: Lab Invest doi: 10.1038/labinvest.3780021 – volume: 277 start-page: 61 year: 2017 ident: 2023111521061578800_jiad344-B25 article-title: Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases publication-title: Immunol Rev doi: 10.1111/imr.12534 – volume: 218 start-page: S504 year: 2018 ident: 2023111521061578800_jiad344-B26 article-title: The induction of IL-1beta secretion through the NLRP3 inflammasome during ebola virus infection publication-title: J Infect Dis doi: 10.1093/infdis/jiy433 – volume: 3 start-page: 795 year: 2015 ident: 2023111521061578800_jiad344-B10 article-title: IFNgamma induces DNA methylation-silenced GPR109A expression via pSTAT1/p300 and H3K18 acetylation in colon cancer publication-title: Cancer Immunol Res doi: 10.1158/2326-6066.CIR-14-0164 – volume: 7 start-page: 1765 year: 2016 ident: 2023111521061578800_jiad344-B5 article-title: Ebola VP40 in exosomes can cause immune cell dysfunction publication-title: Front Microbiol doi: 10.3389/fmicb.2016.01765 – volume: 125 start-page: 131 year: 1978 ident: 2023111521061578800_jiad344-B30 article-title: The pathology of experimental Ebola virus infection in monkeys publication-title: J Pathol doi: 10.1002/path.1711250303 |
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| Snippet | Abstract
Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different... Ebola virus (EBOV) induces cell death not only in infected permissive cells but also in nonpermissive, bystander cells by employing different mechanisms.... |
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| SubjectTerms | Apoptosis Cell Death Cell membranes Cell viability Ebola virus Ebolavirus Ebolavirus - physiology Gene expression Hemorrhagic Fever, Ebola Humans Permissive cells Phosphatidylserine RNA, Messenger RNA, Messenger - metabolism Supplement Viral Proteins Viral Proteins - metabolism VP40 protein |
| Title | Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death |
| URI | https://cir.nii.ac.jp/crid/1871991018123030144 https://www.ncbi.nlm.nih.gov/pubmed/37578011 https://www.proquest.com/docview/3041069208 https://www.proquest.com/docview/2850717341 https://pubmed.ncbi.nlm.nih.gov/PMC10651187 |
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