Anti-aging effects of guanosine in glial cells

• Published in: Purinergic signalling Vol. 12; no. 4; pp. 697 - 706
• Main Authors: Souza, Débora Guerini, Bellaver, Bruna, Bobermin, Larissa Daniele, Souza, Diogo Onofre, Quincozes-Santos, André
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2016; Springer Nature B.V
• Subjects: Aging; Aging - drug effects; Aging - metabolism; Animals; Astrocytes - cytology; Astrocytes - drug effects; Astrocytes - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cytokines; Cytokines - metabolism; Glutamate-Ammonia Ligase - metabolism; Glutamic Acid - metabolism; Glutathione - metabolism; Guanosine - pharmacology; Heme Oxygenase-1 - metabolism; Human Physiology; IL-1β; Immunology; Inflammation; Male; Neurosciences; Original; Original Article; Pharmacology/Toxicology; Rats; Rats, Wistar; Aging; Adult/aged astrocytes; Heme oxygenase 1; Guanosine

Guanosine, a guanine-based purine, has been shown to exert beneficial roles in in vitro and in vivo injury models of neural cells. Guanosine is released from astrocytes and modulates important astroglial functions, including glutamatergic metabolism, antioxidant, and anti-inflammatory activities. As...