Analyses and Insights into Genetic Reassortment and Natural Selection as Key Drivers of Piscine orthoreovirus Evolution

• Published in: Viruses Vol. 16; no. 4; p. 556
• Main Authors: Solarte-Murillo, Laura, Reyes, Humberto, Ojeda, Loreto, Cárcamo, Juan G., Pontigo, Juan Pablo, Loncoman, Carlos A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.04.2024; MDPI
• Subjects: Amino acids; Anemia; Animals; antigenic variation; computer software; cross immunity; Cross-protection; Disease; Double-stranded RNA; Epidemics; Evolution; Evolution, Molecular; Evolutionary genetics; Fish Diseases - virology; Genetic diversity; Genetic Variation; genome; genome diversity; Genome, Viral; Genomes; Genomics; Genotype; Genotype & phenotype; Genotypes; heart; hosts; inflammation; Mortality; Musculoskeletal system; Mutation; Natural selection; Oncorhynchus kisutch; Oncorhynchus mykiss; Oncorhynchus mykiss - virology; Orthoreovirus; Orthoreovirus - classification; Orthoreovirus - genetics; pathogens; Phylogenetics; Phylogeny; Piscine orthoreovirus (PRV); positive selection; Proteins; Reassortant Viruses - classification; Reassortant Viruses - genetics; reassortment; Reoviridae Infections - veterinary; Reoviridae Infections - virology; Ribonucleic acid; RNA; RNA polymerase; Salmo salar; Salmon; segmented genome; Selection, Genetic; Skeletal muscle; Statistical methods; Trout; vaccines; Virulence; Viruses; Chile; Canada; Norway; Piscine orthoreovirus (PRV); reassortment; positive selection; virulence; genome diversity; segmented genome

Piscine orthoreovirus (PRV) is a pathogen that causes heart and skeletal muscle inflammation in Salmo salar and has also been linked to circulatory disorders in other farmed salmonids, such as Oncorhynchus kisutch and Oncorhynchus mykiss. The virus has a segmented, double-stranded RNA genome, which...