Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis

Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans , pathogen of dental caries and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse coliti...

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Published inScientific reports Vol. 2; no. 1; p. 332
Main Authors Kojima, Ayuchi, Nakano, Kazuhiko, Wada, Koichiro, Takahashi, Hirokazu, Katayama, Kazufumi, Yoneda, Masato, Higurashi, Takuma, Nomura, Ryota, Hokamura, Kazuya, Muranaka, Yoshinori, Matsuhashi, Nobuyuki, Umemura, Kazuo, Kamisaki, Yoshinori, Nakajima, Atsushi, Ooshima, Takashi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.03.2012
Nature Publishing Group
Subjects
631/326
692/308
692/699
Animals
Bacteria
Colitis, Ulcerative - microbiology
Colon
Cytokines - biosynthesis
Humanities and Social Sciences
Humans
Infections
Inflammatory bowel disease
Liver - microbiology
Mice
Mouth - microbiology
multidisciplinary
Pathogens
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Rodents
Science
Streptococcus
Streptococcus infections
Streptococcus mutans - pathogenicity
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Abstract Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans , pathogen of dental caries and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans , caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans -mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
AbstractList Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans , pathogen of dental caries and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans , caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans -mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
ArticleNumber 332
Author Takahashi, Hirokazu
Muranaka, Yoshinori
Katayama, Kazufumi
Matsuhashi, Nobuyuki
Nakano, Kazuhiko
Ooshima, Takashi
Kojima, Ayuchi
Wada, Koichiro
Nomura, Ryota
Higurashi, Takuma
Hokamura, Kazuya
Kamisaki, Yoshinori
Umemura, Kazuo
Nakajima, Atsushi
Yoneda, Masato
Author_xml – sequence: 1
  givenname: Ayuchi
  surname: Kojima
  fullname: Kojima, Ayuchi
  organization: Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University, Department of Pharmacology, Graduate School of Dentistry, Osaka University
– sequence: 2
  givenname: Kazuhiko
  surname: Nakano
  fullname: Nakano, Kazuhiko
  organization: Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University
– sequence: 3
  givenname: Koichiro
  surname: Wada
  fullname: Wada, Koichiro
  organization: Department of Pharmacology, Graduate School of Dentistry, Osaka University
– sequence: 4
  givenname: Hirokazu
  surname: Takahashi
  fullname: Takahashi, Hirokazu
  organization: Gastroenterology Division, Yokohama City University School of Medicine
– sequence: 5
  givenname: Kazufumi
  surname: Katayama
  fullname: Katayama, Kazufumi
  organization: Department of Pharmacology, Graduate School of Dentistry, Osaka University, Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University
– sequence: 6
  givenname: Masato
  surname: Yoneda
  fullname: Yoneda, Masato
  organization: Gastroenterology Division, Yokohama City University School of Medicine
– sequence: 7
  givenname: Takuma
  surname: Higurashi
  fullname: Higurashi, Takuma
  organization: Gastroenterology Division, Yokohama City University School of Medicine
– sequence: 8
  givenname: Ryota
  surname: Nomura
  fullname: Nomura, Ryota
  organization: Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University
– sequence: 9
  givenname: Kazuya
  surname: Hokamura
  fullname: Hokamura, Kazuya
  organization: Department of Pharmacology, Hamamatsu University School of Medicine
– sequence: 10
  givenname: Yoshinori
  surname: Muranaka
  fullname: Muranaka, Yoshinori
  organization: Laboratory for Ultrastructure Researches, Hamamatsu University School of Medicine
– sequence: 11
  givenname: Nobuyuki
  surname: Matsuhashi
  fullname: Matsuhashi, Nobuyuki
  organization: Department of Gastroenterology, Kanto Medical Center
– sequence: 12
  givenname: Kazuo
  surname: Umemura
  fullname: Umemura, Kazuo
  organization: Department of Pharmacology, Hamamatsu University School of Medicine
– sequence: 13
  givenname: Yoshinori
  surname: Kamisaki
  fullname: Kamisaki, Yoshinori
  organization: Department of Pharmacology, Graduate School of Dentistry, Osaka University
– sequence: 14
  givenname: Atsushi
  surname: Nakajima
  fullname: Nakajima, Atsushi
  organization: Gastroenterology Division, Yokohama City University School of Medicine
– sequence: 15
  givenname: Takashi
  surname: Ooshima
  fullname: Ooshima, Takashi
  organization: Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22451861$$D View this record in MEDLINE/PubMed
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Snippet Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans , pathogen of dental caries and ulcerative...
Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative...
Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans , pathogen of dental caries, and ulcerative...
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SubjectTerms 631/326
692/308
692/699
Animals
Bacteria
Colitis, Ulcerative - microbiology
Colon
Cytokines - biosynthesis
Humanities and Social Sciences
Humans
Infections
Inflammatory bowel disease
Liver - microbiology
Mice
Mouth - microbiology
multidisciplinary
Pathogens
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Rodents
Science
Streptococcus
Streptococcus infections
Streptococcus mutans - pathogenicity
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Title Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis
URI https://link.springer.com/article/10.1038/srep00332
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