Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia

• Published in: PLoS pathogens Vol. 20; no. 11; p. e1012614
• Main Authors: Wang, Cui, Wen, Jun, Yan, Zijun, Zhou, Yujun, Gong, Zhande, Luo, Ying, Li, Zhenkui, Zheng, Kang, Zhang, Haijun, Ding, Nan, Wang, Chuan, Zhu, Cuiming, Wu, Yimou, Lei, Aihua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.11.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Bacterial pneumonia; Care and treatment; Cytokines; Diagnosis; Health aspects; Infection control; Measurement; Methods; Neutrophils; Pneumonia; Risk factors; China

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation and infection, but its role during M . pneumoniae infection...