Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress

• Published in: Angiogenesis (London) Vol. 16; no. 2; pp. 387 - 404
• Main Authors: Li, Shuping, Sheng, Jinghao, Hu, Jamie K., Yu, Wenhao, Kishikawa, Hiroko, Hu, Miaofen G., Shima, Kaori, Wu, David, Xu, Zhengping, Xin, Winnie, Sims, Katherine B., Landers, John E., Brown, Robert H., Hu, Guo-fu
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2013; Springer Nature B.V
• Subjects: Amyotrophic lateral sclerosis; Angiogenesis; Angiogenin; Animals; Base Sequence; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cardiology; Cell Biology; Cell Line; Cell survival; Coding; Cortex; Degeneration; Differentiation; DNA Primers; Embryo cells; Humans; In Situ Hybridization; Metabolism; Mice; Missense mutation; Motor neurons; Neovascularization, Physiologic; Neurofilaments; Neurogenesis; Neuroprotection; Oncology; Ophthalmology; Original Paper; Polymerase Chain Reaction; Polymorphism, Genetic; Promoters; Ribonuclease; Ribonucleases - genetics; Ribonucleases - metabolism; RNA processing; Single-nucleotide polymorphism; Stem cells; Stress; Superoxide dismutase; Angiogenesis; Neuroprotection; Angiogenin; Ribonuclease 4; Amyotrophic lateral sclerosis (ALS); Neurogenesis

Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin ( ANG ), the fifth member of the vertebrate-specific, secreted ribonucle...