Histopathology-based immunoscore predicts recurrence for intrahepatic cholangiocarcinoma after hepatectomy

• Published in: Cancer Immunology, Immunotherapy Vol. 68; no. 8; pp. 1369 - 1378
• Main Authors: Tian, Meng-Xin, Zhou, Yu-Fu, Qu, Wei-Feng, Liu, Wei-Ren, Jin, Lei, Jiang, Xi-Fei, Wang, Han, Tao, Chen-Yang, Zhou, Pei-Yun, Fang, Yuan, Ding, Zhen-Bin, Peng, Yuan-Fei, Zhou, Jian, Fan, Jia, Shi, Ying-Hong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019; Springer Nature B.V
• Subjects: Antigens, Tumor-Associated, Carbohydrate - metabolism; Atrophy; Biomarkers, Tumor - metabolism; Cancer Research; Cholangiocarcinoma; Cholangiocarcinoma - diagnosis; Cholangiocarcinoma - mortality; Cholangiocarcinoma - pathology; Cohort Studies; Female; gamma-Glutamyltransferase - metabolism; Hepatectomy; Histopathology; Humans; Immunohistochemistry; Immunology; Liver - metabolism; Liver - pathology; Liver Neoplasms - diagnosis; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Male; Malignancy; Medical prognosis; Medicine; Medicine & Public Health; Metastases; Middle Aged; Multivariate analysis; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oncology; Original; Original Article; Prognosis; Research Design; Risk factors; Risk groups; Survival Analysis; Tumor Burden; γ-Glutamyltransferase; Recurrence; Prognosis; Immunoscore; Intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy with poor prognosis. The evaluation of recurrence risk after liver resection is of great importance for ICCs. We aimed to assess the prognostic value of intra- and peritumoral immune infiltrations and to establish a novel histopathology-rela...