Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampu...

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Published inCell Reports Vol. 33; no. 6; p. 108369
Main Authors Wang, Yong-Jie, Liu, Ming-Gang, Wang, Jing-Hua, Cao, Wei, Wu, Cheng, Wang, Zi-Yue, Liu, Li, Yang, Fan, Feng, Zhi-Hui, Sun, Li, Zhang, Fuxing, Shen, Yi, Zhou, Yu-Dong, Zhuo, Min, Luo, Jian-Hong, Xu, Tian-Le, Li, Xiang-Yao
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.11.2020
Elsevier BV
Subjects
Casp3 and GluA1 interaction
Caspase 3
Depression
GluA1 internalization
GluA2
Gyrus Cinguli
Humans
hypersensitivity
LTD
Neuralgia
neuropathic pain
non-apoptotic function
spontaneous pain
synaptic transmission
neuropathic pain
hypersensitivity
Casp3 and GluA1 interaction
spontaneous pain
synaptic transmission
GluA2
caspase 3
LTD
GluA1 internalization
non-apoptotic function
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Abstract Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampus and regulates internalization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits. Whether Casp3-AMPAR interaction is involved in the maintenance of peripheral hypersensitivity after nerve injury remained unknown. Here, we show that nerve injury suppresses long-term depression (LTD) and downregulates Casp3 in the anterior cingulate cortex (ACC). Interfering with interactions between Casp3 and AMPAR subunits or reducing Casp3 activity in the ACC suppresses LTD induction and causes peripheral hypersensitivity. Overexpression of Casp3 restores LTD and reduces peripheral hypersensitivity after nerve injury. We reveal how Casp3 is involved in the maintenance of peripheral hypersensitivity. Our findings suggest that restoration of LTD via Casp3 provides a therapeutic strategy for neuropathic pain management. [Display omitted] •Peripheral nerve injury suppresses LTD and downregulates Casp3 in the ACC•Amino acid sequence (QGCDISP) in AMPAR subunits is identified as a Casp3 binding site•Decreasing cingulate Casp3 suppresses LTD and induces peripheral hypersensitivity•Overexpression of cingulate Casp3 reduces peripheral pain hypersensitivity Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.
AbstractList Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampus and regulates internalization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits. Whether Casp3-AMPAR interaction is involved in the maintenance of peripheral hypersensitivity after nerve injury remained unknown. Here, we show that nerve injury suppresses long-term depression (LTD) and downregulates Casp3 in the anterior cingulate cortex (ACC). Interfering with interactions between Casp3 and AMPAR subunits or reducing Casp3 activity in the ACC suppresses LTD induction and causes peripheral hypersensitivity. Overexpression of Casp3 restores LTD and reduces peripheral hypersensitivity after nerve injury. We reveal how Casp3 is involved in the maintenance of peripheral hypersensitivity. Our findings suggest that restoration of LTD via Casp3 provides a therapeutic strategy for neuropathic pain management.
Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampus and regulates internalization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits. Whether Casp3-AMPAR interaction is involved in the maintenance of peripheral hypersensitivity after nerve injury remained unknown. Here, we show that nerve injury suppresses long-term depression (LTD) and downregulates Casp3 in the anterior cingulate cortex (ACC). Interfering with interactions between Casp3 and AMPAR subunits or reducing Casp3 activity in the ACC suppresses LTD induction and causes peripheral hypersensitivity. Overexpression of Casp3 restores LTD and reduces peripheral hypersensitivity after nerve injury. We reveal how Casp3 is involved in the maintenance of peripheral hypersensitivity. Our findings suggest that restoration of LTD via Casp3 provides a therapeutic strategy for neuropathic pain management. [Display omitted] •Peripheral nerve injury suppresses LTD and downregulates Casp3 in the ACC•Amino acid sequence (QGCDISP) in AMPAR subunits is identified as a Casp3 binding site•Decreasing cingulate Casp3 suppresses LTD and induces peripheral hypersensitivity•Overexpression of cingulate Casp3 reduces peripheral pain hypersensitivity Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.
Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampus and regulates internalization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits. Whether Casp3-AMPAR interaction is involved in the maintenance of peripheral hypersensitivity after nerve injury remained unknown. Here, we show that nerve injury suppresses long-term depression (LTD) and downregulates Casp3 in the anterior cingulate cortex (ACC). Interfering with interactions between Casp3 and AMPAR subunits or reducing Casp3 activity in the ACC suppresses LTD induction and causes peripheral hypersensitivity. Overexpression of Casp3 restores LTD and reduces peripheral hypersensitivity after nerve injury. We reveal how Casp3 is involved in the maintenance of peripheral hypersensitivity. Our findings suggest that restoration of LTD via Casp3 provides a therapeutic strategy for neuropathic pain management.Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory synaptic transmission along somatosensory pathways contributes to neuropathic pain. Caspase 3 (Casp3) plays a non-apoptotic role in the hippocampus and regulates internalization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits. Whether Casp3-AMPAR interaction is involved in the maintenance of peripheral hypersensitivity after nerve injury remained unknown. Here, we show that nerve injury suppresses long-term depression (LTD) and downregulates Casp3 in the anterior cingulate cortex (ACC). Interfering with interactions between Casp3 and AMPAR subunits or reducing Casp3 activity in the ACC suppresses LTD induction and causes peripheral hypersensitivity. Overexpression of Casp3 restores LTD and reduces peripheral hypersensitivity after nerve injury. We reveal how Casp3 is involved in the maintenance of peripheral hypersensitivity. Our findings suggest that restoration of LTD via Casp3 provides a therapeutic strategy for neuropathic pain management.
ArticleNumber 108369
Author Li, Xiang-Yao
Wang, Yong-Jie
Liu, Li
Cao, Wei
Shen, Yi
Zhou, Yu-Dong
Wang, Zi-Yue
Zhang, Fuxing
Luo, Jian-Hong
Xu, Tian-Le
Wang, Jing-Hua
Sun, Li
Feng, Zhi-Hui
Yang, Fan
Wu, Cheng
Zhuo, Min
Liu, Ming-Gang
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  organization: Department of Neurobiology and Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
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  organization: Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058 Zhejiang, China
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  surname: Feng
  fullname: Feng, Zhi-Hui
  organization: Center for Mitochondrial Biology and Medicine, Frontier Institute of Science and Technology, and The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
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  givenname: Li
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  fullname: Sun, Li
  organization: Department of Neurobiology and Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
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  givenname: Fuxing
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  organization: Department of Anatomy and K. K. Leung Brain Research Center, School of Basic Medicine, The Fourth Military Medical University, Xi’an 710032, China
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  givenname: Yi
  surname: Shen
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  organization: Department of Neurobiology and Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
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  givenname: Yu-Dong
  surname: Zhou
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  givenname: Min
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  fullname: Luo, Jian-Hong
  email: luojianhong@zju.edu.cn
  organization: Department of Neurobiology and Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
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Cites_doi 10.1126/science.1191792
10.1523/JNEUROSCI.3121-13.2014
10.1523/JNEUROSCI.3280-14.2015
10.1016/j.biopsych.2015.05.018
10.1084/jem.20031771
10.1016/j.coph.2011.10.018
10.1155/2015/453170
10.1186/1744-8069-10-1
10.1523/JNEUROSCI.1812-08.2008
10.1371/journal.pone.0110539
10.1038/nrn.2016.68
10.1016/j.semcdb.2017.11.037
10.1126/science.aao0862
10.1016/j.pain.2004.01.029
10.1074/mcp.M113.030676
10.1038/ncomms13770
10.15585/mmwr.mm6736a2
10.1006/meth.2001.1262
10.1038/sj.npp.1301559
10.1523/JNEUROSCI.0146-12.2012
10.1016/0165-0270(94)90144-9
10.1016/j.neuron.2007.01.029
10.1186/1744-8069-3-9
10.1523/JNEUROSCI.19-21-09346.1999
10.1046/j.1460-9568.1998.00310.x
10.1111/j.1460-9568.2004.03750.x
10.1126/scisignal.2003778
10.1126/science.aav1483
10.1101/cshperspect.a005710
10.1016/j.neuron.2011.04.004
10.1111/ejn.12330
10.1038/nrn2867
10.1172/JCI77888
10.1016/0896-6273(93)90184-S
10.1002/(SICI)1097-4547(19990801)57:3<315::AID-JNR3>3.0.CO;2-#
10.1074/jbc.RA117.000728
10.1016/j.tins.2014.04.002
10.1523/JNEUROSCI.1222-03.2004
10.1038/npp.2009.20
10.1016/j.cell.2010.03.053
10.1038/nmeth947
10.1038/nrdp.2017.2
10.1177/1073858415588498
10.1002/hipo.20171
10.1097/00001756-200508010-00013
10.1016/j.neuron.2014.12.021
10.1385/NMM:1:1:69
10.1523/JNEUROSCI.2752-13.2014
10.1016/j.neuron.2018.07.018
10.3389/fnmol.2017.00289
10.1213/ANE.0000000000001755
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Keywords neuropathic pain
hypersensitivity
Casp3 and GluA1 interaction
spontaneous pain
synaptic transmission
GluA2
caspase 3
LTD
GluA1 internalization
non-apoptotic function
Language English
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References Collingridge, Peineau, Howland, Wang (bib7) 2010; 11
Qiu, Chen, Koga, Guo, Xu, Song, Wang, Descalzi, Kaang, Luo (bib39) 2013; 6
Citri, Malenka (bib6) 2008; 33
Koga, Descalzi, Chen, Ko, Lu, Li, Son, Kim, Kwak, Huganir (bib21) 2015; 85
Luo, Kuner, Kuner (bib34) 2014; 37
Dong, Han, Li, Bai, Wang, Tu, Peng, Zhou, He, Wu (bib11) 2015; 125
Liu, Morton, Azkue, Zimmermann, Sandkühler (bib28) 1998; 10
Vickers, Clark, Osypenko, Fratzl, Kochubey, Bettler, Schneggenburger (bib45) 2018; 99
Hollville, Deshmukh (bib16) 2018; 82
Mierau, Patrizi, Hensch, Fagiolini (bib36) 2016; 79
Colloca, Ludman, Bouhassira, Baron, Dickenson, Yarnitsky, Freeman, Truini, Attal, Finnerup (bib8) 2017; 3
Ling, Benardo, Sacktor (bib26) 2006; 16
Wang, Zuo, Zhang, Feng, Yan, Li (bib47) 2017; 124
Sandkühler (bib40) 2007; 3
Wei, Li, Zhuo (bib49) 1999; 19
Lüscher, Malenka (bib35) 2012; 4
Zuo, Wang, Liu, Wang, Mei, Feng, Wang, Li (bib52) 2015; 2015
Ertürk, Wang, Sheng (bib13) 2014; 34
Zhang, Zhang, Zhao (bib51) 2005; 16
Liu, Zhuo (bib27) 2014; 10
Liu, Koga, Guo, Kang, Collingridge, Kaang, Zhao, Zhuo (bib29) 2013; 38
Jiao, Li (bib17) 2011; 70
Kumar, van Raam, Salvesen, Cieplak (bib22) 2014; 9
Xu, Wu, Wang, Zhang, Vadakkan, Kim, Steenland, Zhuo (bib50) 2008; 28
Bliss, Collingridge, Kaang, Zhuo (bib3) 2016; 17
Joseph, Levine (bib18) 2004; 20
Paxinos, Franklin (bib37) 2004
Flatters, Bennett (bib14) 2004; 109
Lu, Fu, Salvesen, Mattson (bib33) 2002; 1
Thomas, Grinshpon, Swartz, Clark (bib43) 2018; 293
Li, Ko, Chen, Descalzi, Koga, Wang, Kim, Shang, Kwak, Park (bib23) 2010; 330
Traynelis, Silver, Cull-Candy (bib44) 1993; 11
Chan, Griffin, Mattson (bib4) 1999; 57
Söderberg, Gullberg, Jarvius, Ridderstråle, Leuchowius, Jarvius, Wester, Hydbring, Bahram, Larsson, Landegren (bib42) 2006; 3
Alvarado-Kristensson, Melander, Leandersson, Rönnstrand, Wernstedt, Andersson (bib1) 2004; 199
Peineau, Taghibiglou, Bradley, Wong, Liu, Lu, Lo, Wu, Saule, Bouschet (bib38) 2007; 53
Chaplan, Bach, Pogrel, Chung, Yaksh (bib5) 1994; 53
Wang, Gao (bib46) 2009; 34
El-Boustani, Ip, Breton-Provencher, Knott, Okuno, Bito, Sur (bib12) 2018; 360
Connor, Wang (bib9) 2016; 22
Kang, Liu, Chen, Ko, Baek, Lee, Lee, Collingridge, Kaang, Zhuo (bib19) 2012; 32
Lo, Wang, Weber, Larson, Scearce-Levie, Sheng (bib32) 2015; 35
Klein, Magerl, Hopf, Sandkühler, Treede (bib20) 2004; 24
Awasthi, Ramachandran, Ahmed, Benito, Shinoda, Nitzan, Heukamp, Rannio, Martens, Barth (bib2) 2019; 363
Li, Jo, Jia, Lo, Whitcomb, Jiao, Cho, Sheng (bib24) 2010; 141
Wang, Zuo, Wu, Liu, Feng, Li (bib48) 2017; 10
Sandkühler, Gruber-Schoffnegger (bib41) 2012; 12
Han, Jiao, Jia, Chen, Chen, Gucek, Markey, Li (bib15) 2013; 12
Li, Liu, Deng, Liu, Shang, Ding, Hsu, Jiang, Li, Li (bib25) 2016; 7
Dahlhamer, Lucas, Zelaya, Nahin, Mackey, DeBar, Kerns, Von Korff, Porter, Helmick (bib10) 2018; 67
Liu, Gu, Duan, Li (bib30) 2014; 34
Livak, Schmittgen (bib31) 2001; 25
Liu (10.1016/j.celrep.2020.108369_bib29) 2013; 38
Traynelis (10.1016/j.celrep.2020.108369_bib44) 1993; 11
Qiu (10.1016/j.celrep.2020.108369_bib39) 2013; 6
Bliss (10.1016/j.celrep.2020.108369_bib3) 2016; 17
Chan (10.1016/j.celrep.2020.108369_bib4) 1999; 57
Söderberg (10.1016/j.celrep.2020.108369_bib42) 2006; 3
Ertürk (10.1016/j.celrep.2020.108369_bib13) 2014; 34
Liu (10.1016/j.celrep.2020.108369_bib27) 2014; 10
Flatters (10.1016/j.celrep.2020.108369_bib14) 2004; 109
Ling (10.1016/j.celrep.2020.108369_bib26) 2006; 16
Connor (10.1016/j.celrep.2020.108369_bib9) 2016; 22
Zuo (10.1016/j.celrep.2020.108369_bib52) 2015; 2015
Dong (10.1016/j.celrep.2020.108369_bib11) 2015; 125
Lo (10.1016/j.celrep.2020.108369_bib32) 2015; 35
Koga (10.1016/j.celrep.2020.108369_bib21) 2015; 85
Li (10.1016/j.celrep.2020.108369_bib23) 2010; 330
Liu (10.1016/j.celrep.2020.108369_bib30) 2014; 34
Li (10.1016/j.celrep.2020.108369_bib25) 2016; 7
Li (10.1016/j.celrep.2020.108369_bib24) 2010; 141
Vickers (10.1016/j.celrep.2020.108369_bib45) 2018; 99
Joseph (10.1016/j.celrep.2020.108369_bib18) 2004; 20
Citri (10.1016/j.celrep.2020.108369_bib6) 2008; 33
Kumar (10.1016/j.celrep.2020.108369_bib22) 2014; 9
Zhang (10.1016/j.celrep.2020.108369_bib51) 2005; 16
Livak (10.1016/j.celrep.2020.108369_bib31) 2001; 25
Chaplan (10.1016/j.celrep.2020.108369_bib5) 1994; 53
Colloca (10.1016/j.celrep.2020.108369_bib8) 2017; 3
Peineau (10.1016/j.celrep.2020.108369_bib38) 2007; 53
Xu (10.1016/j.celrep.2020.108369_bib50) 2008; 28
Sandkühler (10.1016/j.celrep.2020.108369_bib41) 2012; 12
Thomas (10.1016/j.celrep.2020.108369_bib43) 2018; 293
Wang (10.1016/j.celrep.2020.108369_bib46) 2009; 34
Alvarado-Kristensson (10.1016/j.celrep.2020.108369_bib1) 2004; 199
Dahlhamer (10.1016/j.celrep.2020.108369_bib10) 2018; 67
Sandkühler (10.1016/j.celrep.2020.108369_bib40) 2007; 3
Hollville (10.1016/j.celrep.2020.108369_bib16) 2018; 82
Jiao (10.1016/j.celrep.2020.108369_bib17) 2011; 70
Paxinos (10.1016/j.celrep.2020.108369_bib37) 2004
Collingridge (10.1016/j.celrep.2020.108369_bib7) 2010; 11
Wang (10.1016/j.celrep.2020.108369_bib47) 2017; 124
Awasthi (10.1016/j.celrep.2020.108369_bib2) 2019; 363
Mierau (10.1016/j.celrep.2020.108369_bib36) 2016; 79
Liu (10.1016/j.celrep.2020.108369_bib28) 1998; 10
Lüscher (10.1016/j.celrep.2020.108369_bib35) 2012; 4
Luo (10.1016/j.celrep.2020.108369_bib34) 2014; 37
Klein (10.1016/j.celrep.2020.108369_bib20) 2004; 24
Han (10.1016/j.celrep.2020.108369_bib15) 2013; 12
Kang (10.1016/j.celrep.2020.108369_bib19) 2012; 32
Lu (10.1016/j.celrep.2020.108369_bib33) 2002; 1
Wei (10.1016/j.celrep.2020.108369_bib49) 1999; 19
Wang (10.1016/j.celrep.2020.108369_bib48) 2017; 10
El-Boustani (10.1016/j.celrep.2020.108369_bib12) 2018; 360
References_xml – volume: 12
  start-page: 3719
  year: 2013
  end-page: 3731
  ident: bib15
  article-title: The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression
  publication-title: Mol. Cell. Proteomics
– volume: 34
  start-page: 2028
  year: 2009
  end-page: 2040
  ident: bib46
  article-title: Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex
  publication-title: Neuropsychopharmacology
– volume: 82
  start-page: 127
  year: 2018
  end-page: 136
  ident: bib16
  article-title: Physiological functions of non-apoptotic caspase activity in the nervous system
  publication-title: Semin. Cell Dev. Biol.
– volume: 37
  start-page: 343
  year: 2014
  end-page: 355
  ident: bib34
  article-title: Synaptic plasticity in pathological pain
  publication-title: Trends Neurosci.
– volume: 38
  start-page: 3128
  year: 2013
  end-page: 3145
  ident: bib29
  article-title: Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
  publication-title: Eur. J. Neurosci.
– volume: 3
  start-page: 995
  year: 2006
  end-page: 1000
  ident: bib42
  article-title: Direct observation of individual endogenous protein complexes in situ by proximity ligation
  publication-title: Nat. Methods
– volume: 360
  start-page: 1349
  year: 2018
  end-page: 1354
  ident: bib12
  article-title: Locally coordinated synaptic plasticity of visual cortex neurons in vivo
  publication-title: Science
– volume: 330
  start-page: 1400
  year: 2010
  end-page: 1404
  ident: bib23
  article-title: Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
  publication-title: Science
– volume: 11
  start-page: 279
  year: 1993
  end-page: 289
  ident: bib44
  article-title: Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse
  publication-title: Neuron
– volume: 9
  start-page: e110539
  year: 2014
  ident: bib22
  article-title: Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates
  publication-title: PLoS ONE
– volume: 25
  start-page: 402
  year: 2001
  end-page: 408
  ident: bib31
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method
  publication-title: Methods
– volume: 363
  start-page: eaav1483
  year: 2019
  ident: bib2
  article-title: Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
  publication-title: Science
– volume: 109
  start-page: 150
  year: 2004
  end-page: 161
  ident: bib14
  article-title: Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
  publication-title: Pain
– volume: 11
  start-page: 459
  year: 2010
  end-page: 473
  ident: bib7
  article-title: Long-term depression in the CNS
  publication-title: Nat. Rev. Neurosci.
– volume: 199
  start-page: 449
  year: 2004
  end-page: 458
  ident: bib1
  article-title: p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
  publication-title: J. Exp. Med.
– volume: 20
  start-page: 2896
  year: 2004
  end-page: 2902
  ident: bib18
  article-title: Caspase signalling in neuropathic and inflammatory pain in the rat
  publication-title: Eur. J. Neurosci.
– volume: 85
  start-page: 377
  year: 2015
  end-page: 389
  ident: bib21
  article-title: Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain
  publication-title: Neuron
– volume: 1
  start-page: 69
  year: 2002
  end-page: 79
  ident: bib33
  article-title: Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death
  publication-title: Neuromolecular Med.
– volume: 10
  start-page: 3069
  year: 1998
  end-page: 3075
  ident: bib28
  article-title: Long-term depression of C-fibre-evoked spinal field potentials by stimulation of primary afferent A delta-fibres in the adult rat
  publication-title: Eur. J. Neurosci.
– volume: 79
  start-page: 746
  year: 2016
  end-page: 754
  ident: bib36
  article-title: Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits
  publication-title: Biol. Psychiatry
– volume: 57
  start-page: 315
  year: 1999
  end-page: 323
  ident: bib4
  article-title: Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer’s disease
  publication-title: J. Neurosci. Res.
– volume: 16
  start-page: 443
  year: 2006
  end-page: 452
  ident: bib26
  article-title: Protein kinase Mzeta enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors
  publication-title: Hippocampus
– volume: 3
  start-page: 17002
  year: 2017
  ident: bib8
  article-title: Neuropathic pain
  publication-title: Nat. Rev. Dis. Primers
– volume: 70
  start-page: 758
  year: 2011
  end-page: 772
  ident: bib17
  article-title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
  publication-title: Neuron
– volume: 34
  start-page: 8741
  year: 2014
  end-page: 8748
  ident: bib30
  article-title: NMDA receptor-dependent LTD is required for consolidation but not acquisition of fear memory
  publication-title: J. Neurosci.
– volume: 7
  start-page: 13770
  year: 2016
  ident: bib25
  article-title: ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion
  publication-title: Nat. Commun.
– volume: 24
  start-page: 964
  year: 2004
  end-page: 971
  ident: bib20
  article-title: Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans
  publication-title: J. Neurosci.
– volume: 3
  start-page: 9
  year: 2007
  ident: bib40
  article-title: Understanding LTP in pain pathways
  publication-title: Mol. Pain
– volume: 10
  start-page: 289
  year: 2017
  ident: bib48
  article-title: Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury
  publication-title: Front. Mol. Neurosci.
– volume: 124
  start-page: 1330
  year: 2017
  end-page: 1338
  ident: bib47
  article-title: The analgesic effects of (5R, 6R) 6-(3-propylthio-1, 2, 5-thiadiazol-4-yl)-1-azabicyclo [3.2. 1] octane on a mouse model of neuropathic pain
  publication-title: Anesth. Analg.
– volume: 28
  start-page: 7445
  year: 2008
  end-page: 7453
  ident: bib50
  article-title: Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
  publication-title: J. Neurosci.
– volume: 53
  start-page: 703
  year: 2007
  end-page: 717
  ident: bib38
  article-title: LTP inhibits LTD in the hippocampus via regulation of GSK3beta
  publication-title: Neuron
– volume: 67
  start-page: 1001
  year: 2018
  end-page: 1006
  ident: bib10
  article-title: Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States, 2016
  publication-title: MMWR Morb. Mortal. Wkly. Rep.
– year: 2004
  ident: bib37
  article-title: The mouse brain in stereotaxic coordinates
– volume: 32
  start-page: 11318
  year: 2012
  end-page: 11329
  ident: bib19
  article-title: Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
  publication-title: J. Neurosci.
– volume: 33
  start-page: 18
  year: 2008
  end-page: 41
  ident: bib6
  article-title: Synaptic plasticity: multiple forms, functions, and mechanisms
  publication-title: Neuropsychopharmacology
– volume: 12
  start-page: 18
  year: 2012
  end-page: 27
  ident: bib41
  article-title: Hyperalgesia by synaptic long-term potentiation (LTP): an update
  publication-title: Curr. Opin. Pharmacol.
– volume: 125
  start-page: 234
  year: 2015
  end-page: 247
  ident: bib11
  article-title: Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis
  publication-title: J. Clin. Invest.
– volume: 2015
  start-page: 453170
  year: 2015
  ident: bib52
  article-title: Huperzine A alleviates mechanical allodynia but not spontaneous pain via muscarinic acetylcholine receptors in mice
  publication-title: Neural Plast.
– volume: 293
  start-page: 5447
  year: 2018
  end-page: 5461
  ident: bib43
  article-title: Modifications to a common phosphorylation network provide individualized control in caspases
  publication-title: J. Biol. Chem.
– volume: 53
  start-page: 55
  year: 1994
  end-page: 63
  ident: bib5
  article-title: Quantitative assessment of tactile allodynia in the rat paw
  publication-title: J. Neurosci. Methods
– volume: 141
  start-page: 859
  year: 2010
  end-page: 871
  ident: bib24
  article-title: Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
  publication-title: Cell
– volume: 99
  start-page: 720
  year: 2018
  end-page: 735.e6
  ident: bib45
  article-title: Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling
  publication-title: Neuron
– volume: 22
  start-page: 359
  year: 2016
  end-page: 371
  ident: bib9
  article-title: A Place at the Table: LTD as a Mediator of Memory Genesis
  publication-title: Neuroscientist
– volume: 10
  start-page: 1
  year: 2014
  ident: bib27
  article-title: Loss of long-term depression in the insular cortex after tail amputation in adult mice
  publication-title: Mol. Pain
– volume: 19
  start-page: 9346
  year: 1999
  end-page: 9354
  ident: bib49
  article-title: Loss of synaptic depression in mammalian anterior cingulate cortex after amputation
  publication-title: J. Neurosci.
– volume: 4
  start-page: a005710
  year: 2012
  ident: bib35
  article-title: NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 16
  start-page: 1197
  year: 2005
  end-page: 1201
  ident: bib51
  article-title: Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats
  publication-title: Neuroreport
– volume: 17
  start-page: 485
  year: 2016
  end-page: 496
  ident: bib3
  article-title: Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
  publication-title: Nat. Rev. Neurosci.
– volume: 35
  start-page: 2118
  year: 2015
  end-page: 2132
  ident: bib32
  article-title: Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control
  publication-title: J. Neurosci.
– volume: 34
  start-page: 1672
  year: 2014
  end-page: 1688
  ident: bib13
  article-title: Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms
  publication-title: J. Neurosci.
– volume: 6
  start-page: ra34
  year: 2013
  ident: bib39
  article-title: An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain
  publication-title: Sci. Signal.
– volume: 330
  start-page: 1400
  year: 2010
  ident: 10.1016/j.celrep.2020.108369_bib23
  article-title: Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
  publication-title: Science
  doi: 10.1126/science.1191792
– volume: 34
  start-page: 1672
  year: 2014
  ident: 10.1016/j.celrep.2020.108369_bib13
  article-title: Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3121-13.2014
– volume: 35
  start-page: 2118
  year: 2015
  ident: 10.1016/j.celrep.2020.108369_bib32
  article-title: Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3280-14.2015
– volume: 79
  start-page: 746
  year: 2016
  ident: 10.1016/j.celrep.2020.108369_bib36
  article-title: Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.05.018
– volume: 199
  start-page: 449
  year: 2004
  ident: 10.1016/j.celrep.2020.108369_bib1
  article-title: p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20031771
– volume: 12
  start-page: 18
  year: 2012
  ident: 10.1016/j.celrep.2020.108369_bib41
  article-title: Hyperalgesia by synaptic long-term potentiation (LTP): an update
  publication-title: Curr. Opin. Pharmacol.
  doi: 10.1016/j.coph.2011.10.018
– volume: 2015
  start-page: 453170
  year: 2015
  ident: 10.1016/j.celrep.2020.108369_bib52
  article-title: Huperzine A alleviates mechanical allodynia but not spontaneous pain via muscarinic acetylcholine receptors in mice
  publication-title: Neural Plast.
  doi: 10.1155/2015/453170
– volume: 10
  start-page: 1
  year: 2014
  ident: 10.1016/j.celrep.2020.108369_bib27
  article-title: Loss of long-term depression in the insular cortex after tail amputation in adult mice
  publication-title: Mol. Pain
  doi: 10.1186/1744-8069-10-1
– volume: 28
  start-page: 7445
  year: 2008
  ident: 10.1016/j.celrep.2020.108369_bib50
  article-title: Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1812-08.2008
– volume: 9
  start-page: e110539
  year: 2014
  ident: 10.1016/j.celrep.2020.108369_bib22
  article-title: Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0110539
– volume: 17
  start-page: 485
  year: 2016
  ident: 10.1016/j.celrep.2020.108369_bib3
  article-title: Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.68
– volume: 82
  start-page: 127
  year: 2018
  ident: 10.1016/j.celrep.2020.108369_bib16
  article-title: Physiological functions of non-apoptotic caspase activity in the nervous system
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2017.11.037
– volume: 360
  start-page: 1349
  year: 2018
  ident: 10.1016/j.celrep.2020.108369_bib12
  article-title: Locally coordinated synaptic plasticity of visual cortex neurons in vivo
  publication-title: Science
  doi: 10.1126/science.aao0862
– volume: 109
  start-page: 150
  year: 2004
  ident: 10.1016/j.celrep.2020.108369_bib14
  article-title: Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
  publication-title: Pain
  doi: 10.1016/j.pain.2004.01.029
– volume: 12
  start-page: 3719
  year: 2013
  ident: 10.1016/j.celrep.2020.108369_bib15
  article-title: The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression
  publication-title: Mol. Cell. Proteomics
  doi: 10.1074/mcp.M113.030676
– volume: 7
  start-page: 13770
  year: 2016
  ident: 10.1016/j.celrep.2020.108369_bib25
  article-title: ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13770
– volume: 67
  start-page: 1001
  year: 2018
  ident: 10.1016/j.celrep.2020.108369_bib10
  article-title: Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States, 2016
  publication-title: MMWR Morb. Mortal. Wkly. Rep.
  doi: 10.15585/mmwr.mm6736a2
– volume: 25
  start-page: 402
  year: 2001
  ident: 10.1016/j.celrep.2020.108369_bib31
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
– volume: 33
  start-page: 18
  year: 2008
  ident: 10.1016/j.celrep.2020.108369_bib6
  article-title: Synaptic plasticity: multiple forms, functions, and mechanisms
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301559
– volume: 32
  start-page: 11318
  year: 2012
  ident: 10.1016/j.celrep.2020.108369_bib19
  article-title: Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0146-12.2012
– volume: 53
  start-page: 55
  year: 1994
  ident: 10.1016/j.celrep.2020.108369_bib5
  article-title: Quantitative assessment of tactile allodynia in the rat paw
  publication-title: J. Neurosci. Methods
  doi: 10.1016/0165-0270(94)90144-9
– volume: 53
  start-page: 703
  year: 2007
  ident: 10.1016/j.celrep.2020.108369_bib38
  article-title: LTP inhibits LTD in the hippocampus via regulation of GSK3beta
  publication-title: Neuron
  doi: 10.1016/j.neuron.2007.01.029
– volume: 3
  start-page: 9
  year: 2007
  ident: 10.1016/j.celrep.2020.108369_bib40
  article-title: Understanding LTP in pain pathways
  publication-title: Mol. Pain
  doi: 10.1186/1744-8069-3-9
– volume: 19
  start-page: 9346
  year: 1999
  ident: 10.1016/j.celrep.2020.108369_bib49
  article-title: Loss of synaptic depression in mammalian anterior cingulate cortex after amputation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.19-21-09346.1999
– volume: 10
  start-page: 3069
  year: 1998
  ident: 10.1016/j.celrep.2020.108369_bib28
  article-title: Long-term depression of C-fibre-evoked spinal field potentials by stimulation of primary afferent A delta-fibres in the adult rat
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.1998.00310.x
– volume: 20
  start-page: 2896
  year: 2004
  ident: 10.1016/j.celrep.2020.108369_bib18
  article-title: Caspase signalling in neuropathic and inflammatory pain in the rat
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2004.03750.x
– volume: 6
  start-page: ra34
  year: 2013
  ident: 10.1016/j.celrep.2020.108369_bib39
  article-title: An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2003778
– volume: 363
  start-page: eaav1483
  year: 2019
  ident: 10.1016/j.celrep.2020.108369_bib2
  article-title: Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
  publication-title: Science
  doi: 10.1126/science.aav1483
– volume: 4
  start-page: a005710
  year: 2012
  ident: 10.1016/j.celrep.2020.108369_bib35
  article-title: NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a005710
– volume: 70
  start-page: 758
  year: 2011
  ident: 10.1016/j.celrep.2020.108369_bib17
  article-title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.04.004
– volume: 38
  start-page: 3128
  year: 2013
  ident: 10.1016/j.celrep.2020.108369_bib29
  article-title: Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.12330
– volume: 11
  start-page: 459
  year: 2010
  ident: 10.1016/j.celrep.2020.108369_bib7
  article-title: Long-term depression in the CNS
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2867
– volume: 125
  start-page: 234
  year: 2015
  ident: 10.1016/j.celrep.2020.108369_bib11
  article-title: Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI77888
– volume: 11
  start-page: 279
  year: 1993
  ident: 10.1016/j.celrep.2020.108369_bib44
  article-title: Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse
  publication-title: Neuron
  doi: 10.1016/0896-6273(93)90184-S
– volume: 57
  start-page: 315
  year: 1999
  ident: 10.1016/j.celrep.2020.108369_bib4
  article-title: Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer’s disease
  publication-title: J. Neurosci. Res.
  doi: 10.1002/(SICI)1097-4547(19990801)57:3<315::AID-JNR3>3.0.CO;2-#
– volume: 293
  start-page: 5447
  year: 2018
  ident: 10.1016/j.celrep.2020.108369_bib43
  article-title: Modifications to a common phosphorylation network provide individualized control in caspases
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA117.000728
– year: 2004
  ident: 10.1016/j.celrep.2020.108369_bib37
– volume: 37
  start-page: 343
  year: 2014
  ident: 10.1016/j.celrep.2020.108369_bib34
  article-title: Synaptic plasticity in pathological pain
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2014.04.002
– volume: 24
  start-page: 964
  year: 2004
  ident: 10.1016/j.celrep.2020.108369_bib20
  article-title: Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1222-03.2004
– volume: 34
  start-page: 2028
  year: 2009
  ident: 10.1016/j.celrep.2020.108369_bib46
  article-title: Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2009.20
– volume: 141
  start-page: 859
  year: 2010
  ident: 10.1016/j.celrep.2020.108369_bib24
  article-title: Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.053
– volume: 3
  start-page: 995
  year: 2006
  ident: 10.1016/j.celrep.2020.108369_bib42
  article-title: Direct observation of individual endogenous protein complexes in situ by proximity ligation
  publication-title: Nat. Methods
  doi: 10.1038/nmeth947
– volume: 3
  start-page: 17002
  year: 2017
  ident: 10.1016/j.celrep.2020.108369_bib8
  article-title: Neuropathic pain
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/nrdp.2017.2
– volume: 22
  start-page: 359
  year: 2016
  ident: 10.1016/j.celrep.2020.108369_bib9
  article-title: A Place at the Table: LTD as a Mediator of Memory Genesis
  publication-title: Neuroscientist
  doi: 10.1177/1073858415588498
– volume: 16
  start-page: 443
  year: 2006
  ident: 10.1016/j.celrep.2020.108369_bib26
  article-title: Protein kinase Mzeta enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors
  publication-title: Hippocampus
  doi: 10.1002/hipo.20171
– volume: 16
  start-page: 1197
  year: 2005
  ident: 10.1016/j.celrep.2020.108369_bib51
  article-title: Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats
  publication-title: Neuroreport
  doi: 10.1097/00001756-200508010-00013
– volume: 85
  start-page: 377
  year: 2015
  ident: 10.1016/j.celrep.2020.108369_bib21
  article-title: Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.12.021
– volume: 1
  start-page: 69
  year: 2002
  ident: 10.1016/j.celrep.2020.108369_bib33
  article-title: Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death
  publication-title: Neuromolecular Med.
  doi: 10.1385/NMM:1:1:69
– volume: 34
  start-page: 8741
  year: 2014
  ident: 10.1016/j.celrep.2020.108369_bib30
  article-title: NMDA receptor-dependent LTD is required for consolidation but not acquisition of fear memory
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2752-13.2014
– volume: 99
  start-page: 720
  year: 2018
  ident: 10.1016/j.celrep.2020.108369_bib45
  article-title: Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.07.018
– volume: 10
  start-page: 289
  year: 2017
  ident: 10.1016/j.celrep.2020.108369_bib48
  article-title: Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2017.00289
– volume: 124
  start-page: 1330
  year: 2017
  ident: 10.1016/j.celrep.2020.108369_bib47
  article-title: The analgesic effects of (5R, 6R) 6-(3-propylthio-1, 2, 5-thiadiazol-4-yl)-1-azabicyclo [3.2. 1] octane on a mouse model of neuropathic pain
  publication-title: Anesth. Analg.
  doi: 10.1213/ANE.0000000000001755
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Snippet Nerve injury in somatosensory pathways may lead to neuropathic pain, which affects the life quality of ∼8% of people. Long-term enhancement of excitatory...
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SubjectTerms Casp3 and GluA1 interaction
Caspase 3
Depression
GluA1 internalization
GluA2
Gyrus Cinguli
Humans
hypersensitivity
LTD
Neuralgia
neuropathic pain
non-apoptotic function
spontaneous pain
synaptic transmission
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Title Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity
URI https://dx.doi.org/10.1016/j.celrep.2020.108369
https://cir.nii.ac.jp/crid/1871428067586405760
https://www.ncbi.nlm.nih.gov/pubmed/33176141
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Volume 33
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