Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis

• Published in: European journal of epidemiology Vol. 33; no. 9; pp. 789 - 810
• Main Authors: Vinceti, Marco, Filippini, Tommaso, Rothman, Kenneth J.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.09.2018; Springer Netherlands; Springer Nature B.V
• Subjects: Antioxidants - administration & dosage; Antioxidants - adverse effects; Antioxidants - metabolism; Cardiology; Computation; Confidence intervals; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; Dietary intake; Dietary supplements; Dietary Supplements - adverse effects; Epidemiology; Exposure; Health risks; Humans; Incidence; Infectious Diseases; Medicine; Medicine & Public Health; META-ANALYSIS; Oncology; Plasma levels; Public Health; Risk; Selenium; Selenium - administration & dosage; Selenium - adverse effects; Systematic review; Trace elements; Type 2 diabetes; Systematic review; Selenium; Epidemiology; Meta-analysis

In 2007, supplementation with the trace element selenium in a trial was unexpectedly found to be associated with an excess risk of type 2 diabetes. Given the concerns raised by these findings and the large number of recent studies on this topic, we reviewed the available literature with respect to t...