MiR-146a in ALS: Contribution to Early Peripheral Nerve Degeneration and Relevance as Disease Biomarker

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 4610
• Main Authors: Giagnorio, Eleonora, Malacarne, Claudia, Cavalcante, Paola, Scandiffio, Letizia, Cattaneo, Marco, Pensato, Viviana, Gellera, Cinzia, Riva, Nilo, Quattrini, Angelo, Dalla Bella, Eleonora, Lauria, Giuseppe, Mantegazza, Renato, Bonanno, Silvia, Marcuzzo, Stefania
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.02.2023; MDPI
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - metabolism; Animals; axon degeneration; Axons - pathology; biomarker; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Body fluids; Degeneration; Development and progression; Disease; Disease Models, Animal; Disease Progression; Early Diagnosis; Gene expression; Genes; Humans; Hybridization; Metabolism; Mice; Mice, Transgenic; MicroRNA; microRNA-146a; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular modelling; Motor neurons; Nerve Degeneration - diagnosis; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nervous system; Neurofilament Proteins; Neuromuscular diseases; Neurophysiology; Pathogenesis; Peripheral nerves; Peripheral Nerves - pathology; Pharmaceutical industry; Physiological aspects; Proteins; Sciatic nerve; Scientific equipment and supplies industry; Spinal cord; Superoxide dismutase; Superoxide Dismutase-1 - genetics; United States; microRNA-146a; biomarker; amyotrophic lateral sclerosis; axon degeneration

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive, irreversible loss of upper and lower motor neurons (UMNs, LMNs). MN axonal dysfunctions are emerging as relevant pathogenic events since the early ALS stages. However, the exact molecular mechanisms leading to MN axon degenerat...