The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

• Published in: Cell host & microbe Vol. 17; no. 2; pp. 260 - 273
• Main Authors: Kostic, Aleksandar D., Gevers, Dirk, Siljander, Heli, Vatanen, Tommi, Hyötyläinen, Tuulia, Hämäläinen, Anu-Maaria, Peet, Aleksandr, Tillmann, Vallo, Pöhö, Päivi, Mattila, Ismo, Lähdesmäki, Harri, Franzosa, Eric A., Vaarala, Outi, de Goffau, Marcus, Harmsen, Hermie, Ilonen, Jorma, Virtanen, Suvi M., Clish, Clary B., Orešič, Matej, Huttenhower, Curtis, Knip, Mikael, Xavier, Ramnik J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.02.2015
• Subjects: Cohort Studies; Diabetes Mellitus, Type 1 - microbiology; Gastrointestinal Microbiome; Gastrointestinal Tract - microbiology; Humans; Infant
• ISSN: 1931-3128; 1934-6069; 1934-6069
• DOI: 10.1016/j.chom.2015.01.001

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisp...