Inhaled sevoflurane may promote progression of amnestic mild cognitive impairment: a prospective, randomized parallel-group study

• Published in: The American journal of the medical sciences Vol. 345; no. 5; p. 355
• Main Authors: Liu, Yongzhe, Pan, Ningling, Ma, Yaqun, Zhang, Shengshuo, Guo, Wenzhi, Li, Haihong, Zhou, Jingli, Liu, Gang, Gao, Minglong
• Format: Journal Article
• Language: English
• Published: United States 01.05.2013
• Subjects: Administration, Inhalation; Aged; Amnesia - cerebrospinal fluid; Amnesia - chemically induced; Amnesia - diagnosis; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - diagnosis; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methyl Ethers - administration & dosage; Methyl Ethers - adverse effects; Neuropsychological Tests; Peptide Fragments - cerebrospinal fluid; Prospective Studies

Amnestic mild cognitive impairment (aMCI) is thought to be a transitional stage between normal aging and the development of Alzheimer's disease (AD). Recent studies have suggested that the inhalational anesthetic isoflurane can induce caspase activation and apoptosis, increase aggregates of β-a...