Reduced Peripheral Skeletal Muscle Mass and Abnormal Reflex Physiology in Chronic Heart Failure

• Published in: Circulation (New York, N.Y.) Vol. 114; no. 2; pp. 126 - 134
• Main Authors: Piepoli, Massimo F., Kaczmarek, Agnieszka, Francis, Darrel P., Davies, L. Ceri, Rauchhaus, Mathias, Jankowska, Ewa A., Anker, Stefan D., Capucci, Alessandro, Banasiak, Waldemar, Ponikowski, Piotr
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 11.07.2006
• Subjects: Aged; Antihypertensive agents; Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Body Composition; Cardiology. Vascular system; Cardiovascular system; Chronic Disease; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Exercise Test; Female; Fundamental and applied biological sciences. Psychology; Heart Failure - physiopathology; Humans; Male; Medical sciences; Middle Aged; Muscle, Skeletal - anatomy & histology; Muscle, Skeletal - physiology; Muscle, Skeletal - physiopathology; Pharmacology. Drug treatments; Reference Values; Reflex - physiology; Ventricular Function, Left; Vertebrates: cardiovascular system; Heart failure; Nervous system diseases; Chronic; nervous system; receptors; Heart disease; ventilation; Cardiovascular disease; reflex; Neurological disorder; Striated muscle; Abnormal reflex

Background— The muscle hypothesis implicates abnormalities in peripheral muscle as a source for the stimulus to the symptoms and reflex abnormalities seen in chronic heart failure (CHF). We investigated the relationship between skeletal muscle mass (with dual-energy x-ray absorptiometry) and activat...