Association of the Presence of Helicobacter in Gallbladder Tissue with Cholelithiasis and Cholecystitis

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Published in	Journal of Clinical Microbiology Vol. 41; no. 12; pp. 5615 - 5618
Main Authors	Silva, Cíntia Presser, Pereira-Lima, Júlio Carlos, Oliveira, Adriana Gonçalves, Guerra, Juliana Becattini, Marques, Daniela Lemos, Sarmanho, Letícia, Cabral, Mônica Maria Demas Álvares, Queiroz, Dulciene Maria Magalhães
Format	Journal Article
Language	English
Published	Washington, DC American Society for Microbiology 01.12.2003
Subjects	Adult Aged Bacteriology Bile - microbiology Biological and medical sciences Cholecystitis - microbiology cholelithiasis Cholelithiasis - microbiology DNA, Bacterial - genetics DNA, Bacterial - isolation & purification DNA, Ribosomal - genetics Female Fundamental and applied biological sciences. Psychology Gallbladder - microbiology Helicobacter Helicobacter - classification Helicobacter - genetics Helicobacter - isolation & purification Helicobacter Infections - complications Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Polymerase Chain Reaction - methods RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics Brazil Spirillales Microbiology Helicobacter Spirillaceae Lithiasis Digestive diseases Bacteria Biliary tract disease Cholecystitis
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Abstract	Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology. For an alternate route to JCM .asm.org, visit: JCM
AbstractList	The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have been observed that may have been due to the small number of subjects studied, difficulty in obtaining a healthy control group, absence of controlling for confounding factors, or differences among populations. Therefore, we investigated the presence of Helicobacter species by culture and nested PCR of 16S rRNA genes in gallbladder tissue and bile from 46 Brazilian subjects with and 18 without cholelithiasis. The control group was mainly composed of liver donors and of patients who had submitted to cholecystectomy as part of the surgical treatment for morbid obesity. No Helicobacter species were grown from the bile or gallbladder tissues. Helicobacter DNA was detected in the gallbladder tissue and bile from 31.3 and 42.9% of the patients, respectively. In a logistic regression model, cholelithiasis was positively and independently associated with the female gender (P = 0.02), increasing age (P = 0.002), and the presence of Helicobacter DNA in the gallbladder tissue (P = 0.009). The presence of Helicobacter DNA in the bile was not associated with cholelithiasis (P = 0.8). A significant association between the presence of Helicobacter DNA in the gallbladder epithelium and histological cholecystitis, even after adjusting for gender and age (P = 0.002), was also observed. The sequences of the 16S rRNA genes were >99% similar to that of Helicobacter pylori. In conclusion, our results support the hypothesis that Helicobacter is associated with the pathogenesis of human cholelithiasis and cholecystitis.The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have been observed that may have been due to the small number of subjects studied, difficulty in obtaining a healthy control group, absence of controlling for confounding factors, or differences among populations. Therefore, we investigated the presence of Helicobacter species by culture and nested PCR of 16S rRNA genes in gallbladder tissue and bile from 46 Brazilian subjects with and 18 without cholelithiasis. The control group was mainly composed of liver donors and of patients who had submitted to cholecystectomy as part of the surgical treatment for morbid obesity. No Helicobacter species were grown from the bile or gallbladder tissues. Helicobacter DNA was detected in the gallbladder tissue and bile from 31.3 and 42.9% of the patients, respectively. In a logistic regression model, cholelithiasis was positively and independently associated with the female gender (P = 0.02), increasing age (P = 0.002), and the presence of Helicobacter DNA in the gallbladder tissue (P = 0.009). The presence of Helicobacter DNA in the bile was not associated with cholelithiasis (P = 0.8). A significant association between the presence of Helicobacter DNA in the gallbladder epithelium and histological cholecystitis, even after adjusting for gender and age (P = 0.002), was also observed. The sequences of the 16S rRNA genes were >99% similar to that of Helicobacter pylori. In conclusion, our results support the hypothesis that Helicobacter is associated with the pathogenesis of human cholelithiasis and cholecystitis. The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have been observed that may have been due to the small number of subjects studied, difficulty in obtaining a healthy control group, absence of controlling for confounding factors, or differences among populations. Therefore, we investigated the presence of Helicobacter species by culture and nested PCR of 16S rRNA genes in gallbladder tissue and bile from 46 Brazilian subjects with and 18 without cholelithiasis. The control group was mainly composed of liver donors and of patients who had submitted to cholecystectomy as part of the surgical treatment for morbid obesity. No Helicobacter species were grown from the bile or gallbladder tissues. Helicobacter DNA was detected in the gallbladder tissue and bile from 31.3 and 42.9% of the patients, respectively. In a logistic regression model, cholelithiasis was positively and independently associated with the female gender ( P = 0.02), increasing age ( P = 0.002), and the presence of Helicobacter DNA in the gallbladder tissue ( P = 0.009). The presence of Helicobacter DNA in the bile was not associated with cholelithiasis ( P = 0.8). A significant association between the presence of Helicobacter DNA in the gallbladder epithelium and histological cholecystitis, even after adjusting for gender and age ( P = 0.002), was also observed. The sequences of the 16S rRNA genes were >99% similar to that of Helicobacter pylori . In conclusion, our results support the hypothesis that Helicobacter is associated with the pathogenesis of human cholelithiasis and cholecystitis. The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have been observed that may have been due to the small number of subjects studied, difficulty in obtaining a healthy control group, absence of controlling for confounding factors, or differences among populations. Therefore, we investigated the presence of Helicobacter species by culture and nested PCR of 16S rRNA genes in gallbladder tissue and bile from 46 Brazilian subjects with and 18 without cholelithiasis. The control group was mainly composed of liver donors and of patients who had submitted to cholecystectomy as part of the surgical treatment for morbid obesity. No Helicobacter species were grown from the bile or gallbladder tissues. Helicobacter DNA was detected in the gallbladder tissue and bile from 31.3 and 42.9% of the patients, respectively. In a logistic regression model, cholelithiasis was positively and independently associated with the female gender (P = 0.02), increasing age (P = 0.002), and the presence of Helicobacter DNA in the gallbladder tissue (P = 0.009). The presence of Helicobacter DNA in the bile was not associated with cholelithiasis (P = 0.8). A significant association between the presence of Helicobacter DNA in the gallbladder epithelium and histological cholecystitis, even after adjusting for gender and age (P = 0.002), was also observed. The sequences of the 16S rRNA genes were >99% similar to that of Helicobacter pylori. In conclusion, our results support the hypothesis that Helicobacter is associated with the pathogenesis of human cholelithiasis and cholecystitis. Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology. For an alternate route to JCM .asm.org, visit: JCM
Author	Juliana Becattini Guerra Mônica Maria Demas Álvares Cabral Letícia Sarmanho Cíntia Presser Silva Adriana Gonçalves Oliveira Dulciene Maria Magalhães Queiroz Daniela Lemos Marques Júlio Carlos Pereira-Lima
AuthorAffiliation	Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, 1 Universidade Luterana do Brasil, Rio Grande do Sul, 2 Laboratory of Research in Bacteriology, 3 Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil 4
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Keywords	Spirillales Microbiology Helicobacter Spirillaceae Lithiasis Digestive diseases Bacteria Biliary tract disease Cholecystitis
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190/4026, 30130-100, Belo Horizonte, MG, Brazil. Phone and fax: 55 31 3274 2767. E-mail: dqueiroz@medicina.ufmg.br.
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Snippet	Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have... The presence of Helicobacter DNA species has been investigated in the biliary epithelium of patients with biliary diseases. However, conflicting results have...
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SubjectTerms	Adult Aged Bacteriology Bile - microbiology Biological and medical sciences Cholecystitis - microbiology cholelithiasis Cholelithiasis - microbiology DNA, Bacterial - genetics DNA, Bacterial - isolation & purification DNA, Ribosomal - genetics Female Fundamental and applied biological sciences. Psychology Gallbladder - microbiology Helicobacter Helicobacter - classification Helicobacter - genetics Helicobacter - isolation & purification Helicobacter Infections - complications Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Polymerase Chain Reaction - methods RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics
Title	Association of the Presence of Helicobacter in Gallbladder Tissue with Cholelithiasis and Cholecystitis
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