Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

• Published in: Blood Vol. 119; no. 9; pp. 2159 - 2170
• Main Authors: Giampietro, Costanza, Taddei, Andrea, Corada, Monica, Sarra-Ferraris, Gian Maria, Alcalay, Myriam, Cavallaro, Ugo, Orsenigo, Fabrizio, Lampugnani, Maria Grazia, Dejana, Elisabetta
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.03.2012; Americain Society of Hematology
• Subjects: Animals; beta Catenin - metabolism; Biological and medical sciences; Cadherins - genetics; Cadherins - metabolism; Cell Adhesion - physiology; Cell Proliferation; Cell Survival - genetics; Endothelial Cells - metabolism; Fibroblast Growth Factors - metabolism; Forkhead Transcription Factors - metabolism; Gene Expression Regulation; Hematologic and hematopoietic diseases; Humans; Medical sciences; Mice; Mice, 129 Strain; Neovascularization, Physiologic - physiology; Phosphatidylinositol 3-Kinases - metabolism; Protein Transport; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Transcription, Genetic; Vascular Endothelial Growth Factors - metabolism; Hematology; Signaling pathway; Cell adhesion molecule; Endothelial cadherin

Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadher...