Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy

• Published in: The Lancet. Rheumatology Vol. 2; no. 11; p. e712
• Main Authors: Nel, Hendrik J, Malmström, Vivianne, Wraith, David C, Thomas, Ranjeny
• Format: Journal Article
• Language: English
• Published: England 01.11.2020

Autoimmune diseases, including rheumatoid arthritis, develop and persist due to impaired immune self-tolerance, which has evolved to regulate inflammatory responses to injury or infection. After diagnosis, patients rarely achieve drug-free remission, and although at-risk individuals can be identifie...