Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training

• Published in: PloS one Vol. 15; no. 9; p. e0238593
• Main Authors: Bartlett, John M. S., Bayani, Jane, Kornaga, Elizabeth N., Danaher, Patrick, Crozier, Cheryl, Piper, Tammy, Yao, Cindy Q., Dunn, Janet A., Boutros, Paul C., Stein, Robert C.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 03.09.2020; Public Library of Science (PLoS)
• Subjects: Algorithms; Breast cancer; Chemotherapy; Comparative analysis; Computer and Information Sciences; Computer applications; Discordance; Gene expression; Medical research; Medicine and Health Sciences; Methods; Patients; Physical Sciences; Research and Analysis Methods; Risk; Robustness; Signatures; Training; Canada; California; United Kingdom > UK; Toronto Ontario Canada

Multiparametric assays for risk stratification are widely used in the management of breast cancer, with applications being developed for a number of other cancer settings. Recent data from multiple sources suggests that different tests may provide different risk estimates at the individual patient l...