Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

• Published in: Cancer cell Vol. 29; no. 5; pp. 653 - 668
• Main Authors: Qu, Le, Ding, Jin, Chen, Cheng, Wu, Zhen-Jie, Liu, Bing, Gao, Yi, Chen, Wei, Liu, Feng, Sun, Wen, Li, Xiao-Feng, Wang, Xue, Wang, Yue, Xu, Zhen-Yu, Gao, Li, Yang, Qing, Xu, Bin, Li, Yao-Ming, Fang, Zi-Yu, Xu, Zhi-Peng, Bao, Yi, Wu, Deng-Shuang, Miao, Xiong, Sun, Hai-Yang, Sun, Ying-Hao, Wang, Hong-Yang, Wang, Lin-Hui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.05.2016
• Subjects: Animals; Antineoplastic Agents - pharmacology; Blotting, Northern; Carcinoma, Renal Cell - blood; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - genetics; Cell Line; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm - genetics; Exosomes - genetics; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Humans; Indoles - pharmacology; Kidney Neoplasms - blood; Kidney Neoplasms - drug therapy; Kidney Neoplasms - genetics; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins c-met - genetics; Pyrroles - pharmacology; Receptor Protein-Tyrosine Kinases - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Neoplasm - genetics; RNA, Neoplasm - metabolism; Signal Transduction - genetics; Treatment Outcome; Xenograft Model Antitumor Assays - methods

Sunitinib resistance is a major challenge for advanced renal cell carcinoma (RCC). Understanding the underlying mechanisms and developing effective strategies against sunitinib resistance are highly desired in the clinic. Here we identified an lncRNA, named lncARSR (lncRNA Activated in RCC with Suni...